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Thread: The Ultimate Opiate Potentiation Thread

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    #51
    Just to bump the thread once more, here is another interesting comment I came up with when searching "morphine potentiate" on google:

    "Any acidifying agents here is not recommended Acidifying agents such as citric acid found in grapefruit juice. In fact, the opposite is recommended. That is-alkylnizing agents such as those found in Tums/Rolaids along with CIMETADINE/Tagament not Pepcid AC Bro. Pepcid is not an alkylnizing agent neither is Cimetadine, but the way Cimetadine suppresses acid production jives really well with the metabolizing of opiates/opiods and thus, potentiates the action thereof and increases(doubles or more) the half-life of such metabolites.

    Benedryl I know for a fact DOES NOT potentiate opiates/opiods. You know why it even ever came to be discussed that the youngins at Erowid weren't/aren't aware of?? It came onto the scene as a way to take tar heroin and using Bendryl and a coffee grinder you could produce a snortable form of tar chiva. So somehow it got crossed over into pharmaceutical opiates/opiods and through urban mythologicals and legends has found it's place where it is today in this present day and age."

    http://72.14.203.104/search?q=cache:...s&ct=clnk&cd=5
     

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    #52
    Quote Originally Posted by redeemer
    Grape fruit juice helps codeine metabolize into morphine instead of the inactive nor-codeine, the same concept happens with dihydrocodeine, hydrocodone and perhaps more, can't remember right now. It's preferred to make the juice yourself out of white grape fruits and including as much pulp as you can since a lot of the desirable enzymes are in that part of the grapefruit.

    After finding out about this I never do the aforementioned opiates without grape fruit juice, I feel like I'm wasting some of the high if I don't (which I infact am).

    From searching threads from the past, I have read quite a few of negregesic's comments, and he tends to know his stuff, saying that grapefruit juice basically wastes codeine and while it increases affects of opiates, codeine is the one exception.
     

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    #53
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    Aight...im too fucked up to fix the chart now but that sounds like the jury is still out on some of this shit....So anyone else got any other interesting shit , mabye that we aint heard of before? also cant wait to see what our moderator *coughparadoxcyclecough* does with this bitch

    Peace
     

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    #54
    this is a REALLY REALLY nice thread. i hope that the stuff about the grapefruit juice is true cuz im gonna try that tommorow. and the day after that, im going to try it with vodka. i FUCKING love oxycodone. I dont know if anyone else likes this drug as much as i do, but why does it make you feel so good? i never really figured this out. anyway, what i was gonna say is you guys forgot about the main thing, XANAX. I never tried grapefruit juice but xanax or any other benzodiazapine is crazyyyy with oxy.
     

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    #55
    [#NMDA antagonists
    (cat's claw, ketamine, DXM, etc....)


    Yeah, i'm sure using ketamine with opiates would get you higher, but you would be wasting the opiate buzz surely???
    whenever i have done k i've lost about 3-4 hours, then woke up junk sick.
     

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    #56
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    im wondering if xanax helps you feel better for the high as in more fucked up or if it actually allows the chemicals in opiates to be processed better so that you feel more

    Cuz of course alcohol, weed, xanax, all that shit is gonna make you feel higher so in that way yes theyre potentiating, but do they actually make the opiate itself more enhanced or do they just make you feel higher cuz youre fucked up on multiple things at once...get what im sayin about the difference?
     

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    #57
    From all I gathered from searching old threads, most of the potentiators of morphine and other opiates are bad for taking with codeine. Other than that, there seems to be a lot of disagreement on when to take them.
    Some say to drink the grapefruit juice 45 minutes prior to taking opiates. Others say to drink them afterwards. I searched and searched and could not find anything close to a definite answer. Some posts even suggested that the substances that are good to take with codeine are bad with morphine, and since codeine has to be converted to morphine, it's a wash, and you basically end up getting more codeine converted to morphine but the morphine leaves your system faster. Unfortunately I couldn't find any type of FAQ on here that covers this. A lot of guys on BL who seem to always know the most on the subject were in disagreement.
     

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    #58
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    ^Well i wish even one of em would post in here!

    Theres some well known mega-knowledge posters on this board and i really wish they asses would come post in this thread and give us some knowledge (ha did anyone else laugh when they read that cuz havin someone "giving knowledge" means somethin a lil different to them)
     

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    #59
    Bluelighter lyserg's Avatar
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    My favorite potentiators would have to be ketamine or xanax.
     

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    #60
    Ok, here is how it goes:

    Grapefruit flavonids inhibit CYP3A4 enzymes. That means that they "stop it from working", and what it is doing is metabolizing products, changing them into forms that will leave the body (in urine).

    http://www.ualberta.ca/~csps/JPPS4(3...grapefruit.htm

    This is why any inhibitor of metabolic enzymes will cause average plasma concentrations to rise.

    Some opiates are metabolized by the enzymes to more potent other opiates. However, it is not the 3A4 type that does this, but 2D6.

    But it is questionable whether the high will correspond with the plasma concentration rise, because the high is many times experienced in correlation to the peak plasma concentration, which will not change if the elimination (metabolism) is slowed down, because 1) the inhibition is never complete, 2) the peaking is stoped by distribution into the tissues (from the plasma) even if no elimination happens at all.

    Many substances that make the high feel better also don't "potentiate" really, as in cause any better pharmacological response to the opiate, but instead "synergize" with the high-response, like old-school anti-histamines that can get into the CNS.
     

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    #61
    Bluelighter jasoncrest's Avatar
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    Quote Originally Posted by chokinvictim
    From all I gathered from searching old threads, most of the potentiators of morphine and other opiates are bad for taking with codeine. Other than that, there seems to be a lot of disagreement on when to take them.
    Yes, most potentiators inhibit CYP2D6 to some extent, which metabolizes Codeine to Morphine.
    I think the only (very) good potentiators of Codeine are Benzos.
     

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    #62
    quinine is a good one, cheap, and can be found in tonic water that you buy from a grocer.
     

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    #63
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    I'm not sure about lunesta, but a small dose of ambien potentiates pharm opiates such as codeine, hydrocodone, and oxycodone greatly in my experience. I have a bunch of the 6.5 mg CR ambiens and taking one sublingually after blowing your usual oxy dose def. ups your high to another level. If you want to get really fucked try mixing a bowl or a couple beers too.
     

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    #64
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    Oh god how i love Oxycontin and Hennesey with a nice bowl......mose beautiful feeling....but anyways, potentiation, yea. Ill edit the chart when i get around to it, good shit comin in peeps, keep it comin.
     

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    #65
    Bluelighter jasoncrest's Avatar
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    Quote Originally Posted by dnbmassive
    quinine is a good one, cheap, and can be found in tonic water that you buy from a grocer.
    How does Quinine potentiate Opiates?
    Is it an enzymatic process, or something else?
     

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    #66
    Quote Originally Posted by Limpet_Chicken
    Taking promethazine with codeine, be sure to wait for the codeine to fully come on, as promethazine is a CYP-P4502D6 substrate, and will inhibit metabolism of codeine to morphine to quite a noticeable extent.

    Hmm, to comment on what you posted. Prometh doesn't really negate any effects of metabolism into morphine; you might want to check that out. There are actual prescriptions of Codeine with Promethazine syrup that is prescribed, I think I've actually had it myself before. You sure you're not confusing this with something else?
     

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    #67
    Quote Originally Posted by jasoncrest
    How does Quinine potentiate Opiates?
    Is it an enzymatic process, or something else?
    Not quite sure jason, I think it perhaps might be enzymatic through the act of a faster absorption/breakdown.
     

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    #68
    Bluelighter Idi0tequ3's Avatar
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    ive heard that hydroxzine helps potentiates opiates as well, is this true?
     

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    #69
    Would opiates potentiate other opiates? For example if one was to take say, 200mg of codeine, and 10mg of oxycodone, would the effects stack up greatly? Would it a case of 'the whole is greater than the sum of the parts' or whatever (eg. GHB & alcohol - 1/2 a dose of GHB + 1/2 a dose of alcohol = more than a whole effects)
     

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    #70
    Quote Originally Posted by dnbmassive
    quinine is a good one, cheap, and can be found in tonic water that you buy from a grocer.
    Aha! This explains why I've come to like Gin & Tonics so much recently. I assume these potentiators also work with Buprenorphine? (Subutex/Suboxone) - I'd really like to know this, because as I have mentioned in a recent thread, I might have to go on a business trip next week, really short notice, and if I can't arrange a temporary transfer of my bupe program, I'm gonna need to make the tiny amount I have at home go a really long way
     

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    #71
    Bluelighter jasoncrest's Avatar
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    Quote Originally Posted by Idi0tequ3
    ive heard that hydroxzine helps potentiates opiates as well, is this true?
    Hydroxyzine is an anticholinergic sedative antihistamine, so I think it potentiates Opiates just like every other anticholinergic sedative antihistamine (promethazine, diphenhydramine, cyclizine...)
     

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    #72
    Dnb, I checked up on the enzymatic interactions of promethazine in the canadian CPS (I'm not canadian, just have a copy) and it is a CYP2D6 substrate, so it doesn't totally inhibit metabolism, but in my experience, taking promethazine before the codeine comes on, significantly weakens the high, taking it after, greatly improves it.
     

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    #73
    Arrow
    Quote Originally Posted by Limpet_Chicken
    Dnb, I checked up on the enzymatic interactions of promethazine in the canadian CPS (I'm not canadian, just have a copy) and it is a CYP2D6 substrate, so it doesn't totally inhibit metabolism, but in my experience, taking promethazine before the codeine comes on, significantly weakens the high, taking it after, greatly improves it.

    touchet', touchet'

    thanks for doin the research bro, I think my experience with prometh and opiates were negligible in a negative way and either was neutral or help assist or prolong a nod in my experience. To each his own, just IMO
     

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    #74
    I use promethazine every time I take codeine, I just wait for the codeine to come on fully before I do take it, taking hte promethazine at the same time, in my experience, greatly pisses on the high.
     

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    #75
    How much Diphenhydramine should one take in order to potentiate a heroin high? Also when should the diphenhydramine be ingested? Anything else worth sharing on this subject?

    Also...Will grapfruit juice help enhance the heroin high or not? It seems like there's a bit controversy about grape fruit juice?

    Best regards, -Psyko
     

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