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☛ Official ☚ The Big and Dandy DOI Thread

Shadowmeister said:
How did it go?
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It didn't.

Peripheral stimulation that made it a bit hard to sleep was the only thing noticed. It amazes me that something as strong as DOI won't be felt due to anti-psychotics. I expected to feel at least SOMETHING but no, didn't happen.
 
Hmmm...wonder if Salvia Divinorum would work.
The Kappa Opioid receptor it hits causes the psychedelic effects. That's a hell of a trip though, not for the faint of heart. Considering you are struggling with mental illness you really need to be careful taking drugs.

This is a harm reduction site, your mental health can get worse. Just try and be careful on this quest, i know you miss tripping and its difficult to give up. But considering my sister has severe schizophrenia, I've seen a person become more and more detached due to the use of psychedelics and dissociatives. Caught up in complex delusions of hell and damnation. She used to be skitzo effective, the drugs made it worse.

She struggles every day
 
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I didn't care for DOI when I took it, it seemed rather generic in character but also very stimulating. It didn't give me any euphoria or very interesting content. I am going to give it a proper try sometime but it's low on my list - I do have some but there are a good number of things I'm going to do first. I'm planning to do either DOPr or DOB soon. Probably DOPr (I've taken a lower dose and felt that it didn't fully develop). For me, DOC is still the best (out of DOC, DOET, DOF, DOI, DOiP, DOM and DOPr), it just has it all, everything I look for in a psychedelic and virtually nothing that I don't like (vasoconstriction is about the only thing I can think of).
 
DOI is one that I really want and am sad that I never picked up back in the day. It's not because I want to use it as a psychedelic–that sounds miserable–but because I want to nanodose it for systemic inflammatory issues. It sounds really promising for tamping down all kinds of systemic inflammation at a subpsychoactive level
 
Oh yeah that's right, I forgot about that. What an interesting property for a psychedelic drug to have.
 
I've never heard about DOI helping inflammation before. Learn something new here everyday in PD, thanks for sharing guys :D

Do any of the other DOx do this and have they figured out why it's happening with DOI?
 
Mind-blowingly amanzing, izo, thanks fro sharing !! Havent read past the abstract, but if it's 5HT2A-R activation alone that mediates the anti-inflammatory effect, then most psychedelics should share this property.

Of course, DOx are special in that they are full agonists at that receptor (IIRC?), so whether you need full agonism to bring out this effect is not clear to me.
 
I never found Doi to be anything special. Not that visual or profound at regular doses. Did 4.5mg-5mg once and although the wide array of effects were considerably weak, while watching porn on cinemax back in 2007, I was getting to the point of climax just from watching. Very deep, virtual reality like or maybe synastasia like senses were making the porn automatically make me feel influenced by it to the point of being overwhelmed. Kind of scary intense feeling. 4mg-5mg is overdose ime
 
Well yeah considering it's strong at like 2mg. 4-5mg is a very high dose.

However I agree, DOI doesn't seem to have anything special about it, subjective effects-wise, even though it's a strong drug. DOC is so much better than it leaves DOI in the dust.
 
Img_9999 said:
Mind-blowingly amanzing, izo, thanks fro sharing !! Havent read past the abstract, but if it's 5HT2A-R activation alone that mediates the anti-inflammatory effect, then most psychedelics should share this property.
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It's even broader than that, non-serotonergic psychedelics do stuff like this as well. Cannabinoids (especially THC) have an influence on the immune system. And salvia can be used to lessen the effects of inflammation too.
 
Would absolutely love to try this, alas doesn't seem to be at all common in Europe (specifically UK).

Have tried DOC (best drug I have experienced - incredible headspace), really would love to try DOM also.

What is the nature of the visual/headspace on DOI? Have read its quite dark, almost horror-ish, which tbf. sounds right up my street.
 
I have tried DOI a couple of times. DOC is also (tied for) my favorite drug. DOI is lacking compared to DOC, the headspace is much colder, and it is more stimulating. It has some really nice visuals, but most of the trip is a lingering stimulation for even longer than DOC's duration. I have talked to ma few people who prefer DOI to DOC but almost everyone greatly prefers DOC.

Actually I have tried DOC, DOM, DOF, DOiP, DOET, DOI, and DOPr, and of them all, DOC is far and away the best, except for DOPr, DOPr is absolute gold as well, it's more intoxicating, more visual, more deeply psychedelic than DOC, but also literally twice the duration which is just a bit much.

DOM is not bad, but I find it a bit transparent... I can't ever seem to get a fully satisfying trip out of it. I've taken it up to 10mg. I found 10mg weaker than 2-2.5mg of DOC. Some people seem to react more fully to DOM than I do, though. DOM has almost no bodyload which is nice, and the duration is a bit lower, but the headspace isn't nearly as good as DOC, nor is the body high.

I am going to try DOB soon, I think I may like it almost as much as DOC/DOPr. But haven't done it yet.
 
I found this on psychonauts wiki about DOI:
"
Besides its action as a psychedelic, DOI has been shown to be an extremely potent inhibitor of tumour necrosis factor-alpha inflammation at picomolar concentrations in cell studies. TNF-alpha is an important target for research into degenerative conditions such as rheumatoid arthritis and Alzheimer's disease where the disease process involves tissue damage through chronic inflammation. This could make DOI and other 5-HT2A agonists an entirely new area for development of novel treatments for these conditions.[6]

DOI has also been shown to induce rapid growth and reorganization of dendritic spines and synaptic connections with other neurons, processes known to underlie neuroplasticity.[7]"

Curious if anyone has tried using this at lower doses for nootropic potentiality.
 
Theta:

Here's a recent study (the full text) that really expands our knowledge of the relationship between psychedelics and anti-inflammatory effects, we've got a lot more to go on than just DOI now.

Structure–Activity Relationship Analysis of Psychedelics in a Rat Model of Asthma Reveals the Anti-Inflammatory Pharmacophore
Psychedelic drugs can exert potent anti-inflammatory effects. However, anti-inflammatory effects do not appear to correlate with behavioral activity, suggesting different underlying mechanisms. We hypothesized that the distinct structural features of psychedelics underlie functionally selective mechanisms at the target 5-HT2A receptor to elicit maximal anti-inflammatory effects. In order to test this hypothesis, we developed a new rat-based screening platform for allergic asthma. Next, we investigated 21 agonists at the 5-HT2A receptor from the three primary chemotypes (phenylalkylamine, ergoline, and tryptamine) for their ability to prevent airways hyperresponsiveness as a measure of pulmonary inflammation. Furthermore, we assessed each drug for in vitro activation of the canonical signaling pathway, calcium mobilization, from the 5-HT2A receptor. We find that the drug 2,5-dimethoxyphenethylamine (2C-H) represents the pharmacophore for anti-inflammatory activity and identify structural modifications that are either permissive or detrimental to anti-inflammatory activity. Additionally, there is no correlation between the ability of a particular psychedelic to activate intracellular calcium mobilization and to prevent the symptoms of asthma or with behavioral potencies. Our results support the notions that specific structural features mediate functional selectivity underlying anti-inflammatory activity and that relevant receptor activated pathways necessary for anti-inflammatory activity are different from canonical signaling pathways. Our results inform on the nature of interactions between ligands at the 5-HT2A receptor as they relate to anti-inflammatory activity and are crucial for the development of new 5-HT2A receptor agonists for anti-inflammatory therapeutics in the clinic that may be devoid of behavioral activity.
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We've got one and a half blotters of DOI saved up, but unfortunately with that being all we've got, we're certainly not going to try to divide it up into tinier dosages to see the sub-psychedelic effect.
 
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