brandnewvibe
Bluelighter
- Joined
- Apr 17, 2005
- Messages
- 6
Stimulating dopamine production: NADH, L-tyrosine, SAM-e and B6
(I apologize if this is the wrong forum, I am new here and and after looking around decided this would be the best place to put it, though I may be wrong.)
I know many people use the dopamine precursor l-tyrosine to pre- or post-load certain substances, and many also use it daily as a supplement for fatigue or attention problems or impulse control. It is also used with great success by some for combatting withdrawal.
I was doing some research today and found two new dopamine precurors that I had not been aware of previously. At least one serves an essential and complementary (with l-tyro) role in dopamine production, and I was wondering if anyone has experimented with a cocktail.
a) NADH (nicotinamide adenine dinucleotide). NADH stimulates tyrosine hydroxylase, the enzyme that converts l-tyrosine to l-dopamine.
b) SAM-e (S-adensoyl-L-methionine). The mechanism of action is unclear (at least I couldn't find anything definitive) but it clearly does dramatically increase brain levels of dopamine and norepinephrine, indicating it may play some role in l-tyrosine conversion.
So, has anyone used NADH + L-tyro? Or all three? Or just SAM-e and L-tyro? I am assuming, perhaps obviously, that B6 would be taken along with the tyrosine.
If no one has experimented with combinations, what do people think about the best order in which to take these? L-tyro first? Or after the NADH? Or at the same time?
(I apologize if this is the wrong forum, I am new here and and after looking around decided this would be the best place to put it, though I may be wrong.)
I know many people use the dopamine precursor l-tyrosine to pre- or post-load certain substances, and many also use it daily as a supplement for fatigue or attention problems or impulse control. It is also used with great success by some for combatting withdrawal.
I was doing some research today and found two new dopamine precurors that I had not been aware of previously. At least one serves an essential and complementary (with l-tyro) role in dopamine production, and I was wondering if anyone has experimented with a cocktail.
a) NADH (nicotinamide adenine dinucleotide). NADH stimulates tyrosine hydroxylase, the enzyme that converts l-tyrosine to l-dopamine.
b) SAM-e (S-adensoyl-L-methionine). The mechanism of action is unclear (at least I couldn't find anything definitive) but it clearly does dramatically increase brain levels of dopamine and norepinephrine, indicating it may play some role in l-tyrosine conversion.
So, has anyone used NADH + L-tyro? Or all three? Or just SAM-e and L-tyro? I am assuming, perhaps obviously, that B6 would be taken along with the tyrosine.
If no one has experimented with combinations, what do people think about the best order in which to take these? L-tyro first? Or after the NADH? Or at the same time?
Last edited: