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Thread: The Big & Dandy 2C-TFM Thread

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    #51
    Hmmm, this one sounds pretty darn interesting. I've seen most of the other research chems available at the usual places, but haven't noticed this one before. I'll have to search for it.
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    #52
    In the name of truth and harmreduction:the batch I tasted (see my report on page1 2C-TFM thread) was about 94% pure,reminder 2C-I.I decided the Jodo to be well below threshold and gave it a try.I'm pretty sure to have been in or close to plus-three land with 5mg.It felt safe though.

    The batch in question with its from 40-50% (hard to determine as the wavelenghts are totally out of sync) CI content had some other minor impurities.I'm not surprised that 8mg won't give even a +3 (whatever batch it was,the CI impurity is a general issue!)

    Be careful with that one.Research chemical means research chemical
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    #53
    Bluelight Crew fastandbulbous's Avatar
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    I'd guess that the degree to which the group attached at the 4 position is able to 'pull' the delocalized pi electrons of the aromatic ring will have a correlation to the potency. Obvious other factors (as mentioned above) are polarity and size. Polarity is important as any highly polar group will not fit into the space allowed by the receptor molecule, most probably because of electrostatic charge repulsion. Also it will severely hinder the ability of the molecule to cross the blood brain barrier. Size is a factor, as shown by Shulgin - the fact that the DOx compound with a pentyl group attached to the 4 position (DOAM) is inactive.

    Attached is a jpeg showing the effect of the CF3 group on the delocalized pi electrons. All of the halogens (and some groups such as -CN and -CH2CH2F) have the same effect on said electrons, but to a lesser degree.

    Possibly anything capable of doing this to a greater degree than CF3, but while remaining lipophillic (non-polar) would turn out to be even more potent (if anybody out there with a good understanding of mechanisms of org chemistry can suggest a better group, don't be shy!)
    Last edited by fastandbulbous; 08-12-2005 at 12:30.
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    #54
    I always thought a F3C-CH2 would be an attractive group, considering the increase in potency form CH3 to CH3-CH2. Another advantage is that it's probably chemically feasible.

    If I remember correctly... DOAM has a very high affinity for the 5-HT2A receptor, but it has either very low intrinsic efficiacy, or is an antagonist.

    An other compound, 1-(3,5-dimethoxy-4-(3-phenylpropyl)phenyl)propan-2-amine, with a group of even larger size than amyl in the 4-position, has a Ki of 4nM @ 5-HT2A and 109% efficiacy. In this series even compounds with only one methoxy are very active:
    1-(2-methoxy-4-(3-phenylpropyl)phenyl)propan-2-amine: Ki 8nM, Emax 63% (which is still sufficient for psychedelic activity).
    1-(3-methoxy-4-(3-phenylpropyl)phenyl)propan-2-amine: Ki 17nM, Emax 90%.
    For comparison, the same paper gives a Ki of 16nM for 2C-B and 32nM for DOB (not, it's not a mistake).

    Would be interesting to combine the 4-(3-phenylpropyl) with the dragonfly wings! Or to stick some fluorine on the tail phenyl...
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    #55
    Bluelight Crew fastandbulbous's Avatar
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    I always thought a F3C-CH2 would be an attractive group, considering the increase in potency form CH3 to CH3-CH2
    That's why I thought the pentafluoroethyl group (CF3CF2-) might also be a winner, as long as it's not too physically large. Other possible candidates would be methoxydifluoromethyl (CH3OCF2-) and trifluoromethoxydifluoromethyl (CF3OCF2-) as they'd both be quite strong electron withdrawing groups, but at the optimum 3 atoms long chain seen with the 4-propyl compounds (again pending steric considerations).

    As for the large 4-substituent groups, I'm sure I've read somewhere that they're either partial antagonists or just ligands that bind and don't do much at all (other than prevent anything else binding)
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    #56
    " Possibly anything capable of doing this to a greater degree than CF3, but while remaining lipophillic (non-polar) would turn out to be even more potent (if anybody out there with a good understanding of mechanisms of org chemistry can suggest a better group, don't be shy!)"

    1-(2,5-Dimethoxy-4-(pentafluorsulfanyl)phenyl)-aminoethane.Yes,SF5.An extension of the highly effective TFM group,the sulfur is known and allowed at the 4 position.The thing might be a bit too big,but then,the weight is 127 like the jodo which is tolerated.There is a surprisingly sparse literature about the SF5 group (fertile ground I would say,fellow scientists!),it is stable like stone,not too difficult to make.I doubt this has ever been made into a pharmaceutical molecule.
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    #57
    Bluelight Crew fastandbulbous's Avatar
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    Wondering whether the activity -f an SF5 would be like the 4-halogen, 4-alkylthio, or like that of 2C-T-21. If I had to place a bet, I'd think it's be most like 2C-T-21, but a sight more potent
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    impure 2c-tfm LCMS results 
    #58
    That impure 2c-tfm that most people got, LC/MS,

    -----
    40.5% 2C-TFM, 42.2% 2C-I, and 4 other compounds present in 4.0, 4.4, 5.8 and 3.0 %'s

    The masses I see are
    207/208,
    307/309 (2C-I),
    250/251/264 (-TFM and I dunno whats up with the 264)
    244
    215
    and also a peak in the "show me all masses present" of 182.1 which could be the M+1 for 2C-H
    ------

    I don't have any of the images yet (analysed a buncha shit) but thats what my friend's got right now. Well shit 2c-tfm must be pretty fuckin' potent cause it doesn't take much of the above mix to work good, and it didn't really feel like 2c-i (i dont know whats the highest dose i've taken) it felt like the other "more pure" tfm I had a 1mg taste of.

    I hope some pure 2C-TFM shows up again cause I definitely liked it, and i'd like to see how potent it really is and the effects at the higher levels without 2c-i. Also i bet DOTFM is ultra potent, and DOTFM-fly or dragonfly nfly fuck..
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    #59
    hugo24, any correspondence with your earlier data in re the nature of the contaminants?
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    #60
    What wavelength have your results been measured yaesutom (I guess 220nm)?2-CI and 2-TFM have very different absorption patterns (Trifuoromethyl is very elektronegative and distorts the aromat,plus iodo stuff often adds odd UV itensity),I found 230 the most accurate for those 2 because it corresponds the closest with NMR data.

    The 220nm data says 46.8% 2C-TFM,49.7% 2C-I and 3.47% of an unknown polar compound XX (2smaller compounds present but unintegrated, I lost the HPLC data to reintegrate).

    At 230nm: 57.9% 2C-TFM,37.7% 2C-I,2.08% imp.,1.84% imp. (ment. above),0.9% imp...I might do it again as there were doubts regarding baseline separation/slightly contaminated TFA,but it won't change the big picture.

    The MS:Usually the phens show also a peak minus 17 (ammonia),264 might be that plus Methanol?
    XX/with mass 215(217?) maybe 2C-C from the Jodmonochloride jodination?
    On the others I have to pass.Maybe C6H6 has a good idea?In the halogenated you usually have some isomers/overreacted compounds present.
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    #61
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    I hadn't realized this thread existed. Since there is a wealth of information (compared to elsewhere) about 2C-TFM (and/or the impure batch), I have big and dandified it.
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    #62
    The drawing is correct,a benzyl has an CH2 on the phenylring.
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    #63
    anyone sample real 2ctfm that had no 2ci in it if so id like to here about it.I heard this stuff was really good im dieing to try it
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    #64
    Bluelight Crew Delsyd's Avatar
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    it came and it went

    now its a thing of legends.

    (then again legends never die as has been shown with 2cb, 2ct7, 5 meo dipt, amt, DOM, psilocin and plethora of other substabces)

    I await the return of this exotic phenethylamine
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    #65
    Quote Originally Posted by fastandbulbous
    Wondering whether the activity -f an SF5 would be like the 4-halogen, 4-alkylthio, or like that of 2C-T-21. If I had to place a bet, I'd think it's be most like 2C-T-21, but a sight more potent
    Are you sure that the 2C-SF5 is like other 2C-T-X ? In the pentafluorosulfanyl, the four fluor-atoms take two electron-pair of the sulfur-atom, not in the 2C-T-x ...

    The SF5 has no similarity with thioethers. It is extremely lipophilic with very strong electron withdrawing due to flor-atoms. This is a sort of super pseudo halogen... bigger than iodine and more lipophilic than trifluoromethyl !

    Does anyone know how the -SF5 group are eliminated out of the body ? ?
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    #66
    That was the original rational for its designing,highly lipophilic yet strongly electron withdrawing,sort of an extension to the so far most potent groups beyond Jodine like Trifluoromethyl,2-Fluoroethylthio,2-Fluoroethyl and maybe the 2,2,2-Trifluoroethylthio/2,2,2-Trifluoroethyl (the latter two exist as well but human data is not public yet to my knowledge).Though your point about Sulfurs different oxidation state is valid.And chances that the SF5 is finally too big there are intact to formulate it positively.

    As for the metabolism I would say it is stable like a stone (welcomed in the 2C series) as the SF5 is mostly inert (read up also on SF6:

    http://de.wikipedia.org/wiki/Schwefelhexafluorid )

    But as with all new things its expected to be a black box,ready to be enlightned!

    Btw the problem with the 2C-J contaminant in 2C-TFM is hard to solve,some will be steered away by this potentially legal issue.
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    #67
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    Well I haven't heard of this being at all avail;able in a long time, and the 2C-TFM that WAS available at one point turned out to be 50% 2C-I if I recall correctly. I highly doubt these gels (you also said blotter though? Any 2C-X could fit into gel tabs I think, no problem). 6-7 hours, not that intense? It could be a lot of things, and I think jumping to 2C-TFM as a conclusion is probably making a whole lot of assumptions, and given its extreme rarity, it's highly unlikely. Someone with 2C-TFM would probably try to sell it as 2C-TFM because if they managed to get some, they'd have to be tapped into the online community, and loads of people in the online community would pay eagerly to have some 2C-TFM.
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    #68
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    Quote Originally Posted by Xorkoth View Post
    Well I haven't heard of this being at all avail;able in a long time, and the 2C-TFM that WAS available at one point turned out to be 50% 2C-I if I recall correctly. I highly doubt these gels (you also said blotter though? Any 2C-X could fit into gel tabs I think, no problem). 6-7 hours, not that intense? It could be a lot of things, and I think jumping to 2C-TFM as a conclusion is probably making a whole lot of assumptions, and given its extreme rarity, it's highly unlikely. Someone with 2C-TFM would probably try to sell it as 2C-TFM because if they managed to get some, they'd have to be tapped into the online community, and loads of people in the online community would pay eagerly to have some 2C-TFM.
    Yeah you make a great point. I personally have a lot of experience with the 2c-x's (and various RC's), and I know 100% that these geltabs were a 2c-x compound. (no blotters, they were red "geltabs" which were extremely hard, almost like plastic, with white specks embedded in them, very bitter.)

    I have more experience with 2c-e than 2c-I, but the lack of uncomfortable body load (and back tingles I get on 2c-e, up and down my spine) made me believe it is 2c-I, although I did have suspicions it was something else(2c-tfm). But you're right, that compound is extremely rare, and hasn't been around in years.

    Definitely not 2c-b, maybe 2c-I.

    Mostly curious because I'm sitting on a strip of some good WoW and would love to combine it with some 2c-e/i, but I'm trying to pinpoint what substance it is before dropping it all (the responsible thing to do IMO).

    Oh, and I really appreciate the reply Xorkoth.
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    #69
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    Well if you're sure it's a 2C-X you could combine with LSD... I mean, I don't know of any psychedelics that have a bad reaction with LSD.

    It does sound like it could be 2C-I. But honestly it's impossible to tell without scientific testing methods like GC/MS or LC/MS.
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    #70
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    I've heard loads of reports lately of 2C-B( hydrobromide i would imagine, for ease of solubility in water. . the hcl is a bitch) in gelatin tabs so it makes sense that other 2Cs would follow. Im suprised it hasnt been done before, considering the ease of working with gelatin and the difficulty of pressed tablets or tediousness of loading capsules. But then again, up until fairly recently the 2Cs were more of a conneisseurs drug rather than mass market, and the discriminating consumer wanted identifiable unadulterated products. But this seems to be changing.......
    Last edited by amanitadine; 16-11-2010 at 03:57.
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    #71
    Long time lurker, first time post.

    Firstly, way to clutter the big and dandy lol. Literally nothing on 2C-TFM provided here.
    Recently stumbled upon this... well an exhausting stumble. H-NMR confirmed, MP test showed no cuts, no impurities.

    Conducting trials, will report to everyone when I get a good grasp of this chemical.
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    #72
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    This compound has recently come available to me if I so choose.

    I scanned this thread and haven't found any viable information as per dosing, half-life, duration, effects. Anyone care to chime in do it now.
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    #73
    Did you read the thread? As far as I recall there is both dosage and duration in there. A realistic Dosage I think turned out around 15 mg, if my memory serves me right, but don't hang me up on that. So start low of cause.

    Many vendors have been looking to stock this one, and eventually it will pop up for sure. But if this, what is available to you, is from that dude, on a forum that I shall not name here, who claim to have had a custom synthesis made, then I don't believe he has the real deal. I think he believes it himself, sure. But he's pretty concieted and not very mature imo.

    lol, what ever. I do hope a legit source is stocking it. Would be all the rage
    Last edited by Fagott; 05-12-2012 at 21:24.
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    #74
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    Different dude.

    I just scanned the thread and found it. Whoops must have passed that up. Would love to get more anecdotal info though.

    Trip reporters rally up!
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    #75
    I have some on the way in a few days. From my source 25mg is a moderate dose this is supposedly pure, unlike the 2c-i tainted batch. Still I'm a little concerned at the low dose levels reported earlier in this thread., but as always start low. Unlike some other posters I WILL actually post some feedback once I have been able to test this substance.
    Last edited by RUSHDAFUNK; 18-12-2012 at 20:32.
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