Bluelight

Thread: Injecting Hydrocodone

Results 1 to 9 of 9
  1. Collapse Details
    Injecting Hydrocodone 
    #1
    Ex-Bluelighter
    Join Date
    Sep 2004
    Location
    Virginny
    Posts
    3,124
    Can hydrocodone be IV'd?

    Is it worthwhile in your opinion, does anyone have any experience, and can you please explain it?

    This is not "can I IV vicodans"

    This is can HYDROCODONE be iv'd?
     

  2. Collapse Details
     
    #2
    Bluelighter soundphaRm's Avatar
    Join Date
    Jan 2004
    Location
    From: Trinidad, Humboldt Co., CA
    Posts
    2,441
    There are no formulations of hydrocodone available in a parenteral form, because, like codeine, significant pulmonary edema would result- very bad for you- it can cause death rather quickly. As far as I know, oxycodone is the only member of the 'codone family' (itself a thebaine derivative, though...), that can be safely injected, w/o the risk of P.E...
    It (hydro) can (like codeine) be given IM, but unless you have the amps designed for it, I wouldn't do it, just because IM is a good way to get some nasty abcesses, if the product is not close to 100% pure (USP).
    Unless this grosses you out, I'd suggest performing a CWE on your hydrocodone, and make youself a nice 'hydro enema'. For real...
    But since the oral bioavailability w/ hydo is so high, just drink it down. To get the most absorption from your gut, though, about 20-25 min. before you dose, drink some baking soda water (about 3/4 tsp. in approx- 1/3 cup of water). It won't work miracles, but it'll help a bit w/ the absorption.
    Now another thing you might want to try, is to take some cimetidine (OTC- Tagamet). Cimetidine is a pretty potent inhibitor of the hepatic (liver) enzyme (CYP-2D6) that helps to break down hydrocodone in your system. It works for me anyway...
    It doesn't make it hit you that much harder, but it increaes the duration of it quite a bit...Hope this helps 'ya..
     

  3. Collapse Details
     
    #3
    Bluelight Crew fastandbulbous's Avatar
    Join Date
    Jul 2004
    Location
    that rainy little island off europe
    Posts
    20,524
    Cimetidine is a pretty potent inhibitor of the hepatic (liver) enzyme (CYP-2D6) that helps to break down hydrocodone in your system. It works for me anyway...
    Cimetidine inhibits CYP3A4/5. Inhibiting 2D6 prevents the O-demethylation of hydrocodone to hydromorphone, 3A4 prevents N-demethylation of hydrocodone to nor-hydrocodone (and hydromorphone to nor-hydromorphone). As out of all those compounds, hydromorphone is the most potent mu agonist, the best result would be to take something that inhibits 3A4 and induces 2D6. The latter is only achieved by compounds you wouldn't volunteer to take without an illness, so 3A4 inhibitors are the only real option.

    As far as choice of inhibitor goes, I wouldn't suggest cimetidine straight off, as at larger doses it is a non-specific inhibitor of cytochrome P450; my 1st choice would be grapefruit juice - not only does it inhibit 3A4, but the volume of juice also prevents the constipation that comes with all the codeine derivatives (well 750ml prevents constipation for me - and that's the real problem I have with codeine & family).

    As to the original question - yes but you've also had the reasons it's not a good idea explained as well
     

  4. Collapse Details
     
    #4
    search for negrogesic's foray into mindblowingly large IV'd hydrocodone adventures...although if I recall correctly it was indeed USP grade...

    and to kill two birds with one stone....i've taken 400mgs cimetidine with my normal hydro dosage levels quite often in the past 1-2 months, and I swear the last time I battled the Vikings, sans cimetidine, the duration actually was longer....i keep trying to play around with dosages, length of time ingested before hydro ingestion, but I can never garner a conclusive opinion as to its effects regarding cim.

    I believe I will try the baking soda "trick" today...
     

  5. Collapse Details
     
    #5
    Bluelighter Rosclot's Avatar
    Join Date
    Oct 2004
    Location
    Chicago
    Posts
    1,422
    Originally posted by soundphaRm
    . To get the most absorption from your gut, though, about 20-25 min. before you dose, drink some baking soda water (about 3/4 tsp. in approx- 1/3 cup of water). It won't work miracles, but it'll help a bit w/ the absorption.
    Does this work with all opiate, oxycodone in particular
     

  6. Collapse Details
     
    #6
    Ex-Bluelighter
    Join Date
    Sep 2004
    Location
    Virginny
    Posts
    3,124
    I'm a bit confused here, soundphaRm just said that injecting hydrocodone, will, like codeine, cause pulmunary edema, where water fills up your lungs and the reason why people don't IV (or IM for that matter) codeine.

    Yet, people are also saying here if you have pure, lab grade, USP hydrocodone, it can be injected IM/IV safely.

    That's where I'm lost.

    Also, I understand shooting vicodans is bad, and that the APAP will hurt you. I am assuming perhaps this mixup is because your saying shooting vicodans will cause Pulmunary edema?

    So can it be assumed that APAP causes pulmunary edema when injected/IM'd?
     

  7. Collapse Details
     
    #7
    Ex-Bluelighter the armed forces's Avatar
    Join Date
    Jan 2004
    Location
    Atlanta, GA
    Posts
    1,125
    Search for negrogesics post on this. It's a hella good reference.
     

  8. Collapse Details
     
    #8
    Bluelight Crew negrogesic's Avatar
    Join Date
    Jul 2002
    Location
    Negronesia
    Posts
    4,707
    ^^^Beat me to it, but yes, that is a decent reference.

    I have gone in some depth into this subject in some old thread and a search should be of use, and yes, i HAVE injected norcos (get ready to whip out your 10cc rigs, or poke yourself a dozen times). What a waste of time, honestly it took me forever to prep that monster. Save your hydrocodone and buy some heroin, unless your down to this, in which i can say, get off opioids while hydrocodone in ANY form can get you high. Just keep in mind the maximum solubility, and more importantly, the risk reward benefit (endocarditis was mentioned)

    IVing hydroodone SUCKS, and im not one to turn down a mu agonist......
    Last edited by negrogesic; 01-03-2005 at 05:59.
     

  9. Collapse Details
     
    #9
    Ex-Bluelighter
    Join Date
    Sep 2004
    Location
    Virginny
    Posts
    3,124
    I couldn't find it, I looked up "negrogesic hydrocodone" and "injecting hydrocodone".

    I saw your "Behemoth oral hydrocodone dose" post though. Very interesting. Did you ever try the test again, with a higher dosage (1g was what you were saying you'd need)
     

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •