Negro,I am flabbergasted!Any citric juice does the opposite with methadone.It depletes the bodys reserves [eats through the dose].Never drink any citrus juice with methadone.
I know, vitamin C seems to make methadone not work nearly as well as it should, that why i dont take multi-vitamins or citrus juices. I tried grapefruit juice once, honestly i wasnt really experimenting, it was all that was in my fridge, because it was either that or beer (which also makes methadone work poorly). I definately try to stay from citrus drinks and vitamin C.
But i do find that a little food (non-greasy), mainly simple/complex carbohydrates, help the methadone kick in a little faster/stronger.
But yes, it does seem stupid that i drank grapefruit juice with my methadone, but it was either that or beer (i didnt want to drink the nasty heavily chlorinated tap water i get in my apartment). I didnt go into withdrawal or anything, but i definately didnt help. But i really didnt mean to take grapefruit juice with the methadone, it was sort of a fluke.
Bottom line, dont take citrus drinks or vitamin C with methadone........
Cimetidine seems to possibly work, depending on who you talk to, i dont really feel it does much other than possibly increase the duration. But i dont take anything with my methadone aside from a little food, and BOTTLED water......