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Opioids Loperamide (Immodium) Megathread: We have now lost at least 2 of our own from Lope

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To me it just seems ridiculous (and extremely painful) to take anti-diarrhea medication to get high. I have to take a bunch of pills because of chronic pain, and the digestive side effects aren't fun at all. My shits are easily 1.5 times the size of porn stars' dicks, they're hard as a boulder, and it takes every last bit of strength to get them out. But I guess to each his own. If having a torn asshole and hemorrhoids is what get's you off, be my guest.
 
To me it just seems ridiculous (and extremely painful) to take anti-diarrhea medication to get high. I have to take a bunch of pills because of chronic pain, and the digestive side effects aren't fun at all. My shits are easily 1.5 times the size of porn stars' dicks, they're hard as a boulder, and it takes every last bit of strength to get them out. But I guess to each his own. If having a torn asshole and hemorrhoids is what get's you off, be my guest.

Effectively countered with stool softeners. In some cases my BMs have been softer than normal despite taking gargantuan doses of Loperamide. There were even times I had to reduce my Miralax dose because I was going too often. Also, like central mu receptors one develops a tolerance peripherally as well.

But yes, it is indeed extremely painful to have such a BM, it almost brought me to tears once. Thankfully I have taken preventative action since.

And not any more ridiculous than dissolving some brown powder from south of the border and IVing it ;) (No offense to H users, I am not asserting that I am superior because I don't IV or anything like that, just using it as an example). The euphoria from opiates/opioids whether they are labelled anti-diarrheal or not is worth the pitfalls for many, obviously.

If something gets you very euphoric through mu-opioid agonization (and I know Lope does not do so for everyone) given its accessibility and its cheapness compared to illicit opis does it matter what its FDA approved indication is? I am able to get noddy daily if I so choose without even putting a serious dent in my income and I am on unemployment right now.
 
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To me it just seems ridiculous (and extremely painful) to take anti-diarrhea medication to get high. I have to take a bunch of pills because of chronic pain, and the digestive side effects aren't fun at all. My shits are easily 1.5 times the size of porn stars' dicks, they're hard as a boulder, and it takes every last bit of strength to get them out. But I guess to each his own. If having a torn asshole and hemorrhoids is what get's you off, be my guest.

The funny thing about this is that most people will have this same knee jerk reaction when first learning about loperamide. Myself included. "ANTI POOP PILLS? LOL BRO U DUMB." These kinds of responses are expected, but I urge you to read more into this with an open mind.

It's really awesome that loperamide is so easily accessible. Truly a poor mans methadone.

Loperamide IS a potent, peripherally acting opiate. A full mu-agonist. Meaning that is a potent opiate, but since it does not cross the blood brain barrier but in trace amounts, won't bring on the opiate effects you and I know and love.

However, taken in huge amounts, loperamide can and will induce intoxication. I've never used it in that high of a dosage, only 26 milligrams or so max for withdrawal abortion. Works amazingly. It removed about 80% of my physical withdrawal symptoms. I was able to function, and of course poop(eventually.)

Loperamide is not a fucking joke. It is a no bullshit opiate. The constipiation is similar to that of other full agonists, if not a little longer in duration thanks to its extremely long half-life. It can be countered like all opiate induced constipation: kinda sorta. Large amounts of water, stool softeners and a high fiber intake are all things you should already be trying to counter opiate-stipiation.

Try not to strain so hard either, you take tramadol, right? Tramadol constipiation is MUCH worse for some reason than most other forms of opiate constipation I've dealt with. But there are options, you know?
Try switching the dose times of your pills so that when you wake up in the morning you have minimal tramadol left over in your system, so that you can try to go to the bathroom before you take your morning dose. I was prescribed 6 tramadol a day awhile back and that was the only way I ended up being able to cope with the pluggage.

Don't bag on lope if you don't know your dope.
 
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Poetic, but the only thing I've found to truly help me is a saline lax. Which completely reverses it. I've tried stimulant lax.which didn't work, tried stool softeners, hell, even did a suppository which didn't really yield the results I needed. So it seems I can remain plugged up or I can let all my food go down the slip and slide that my intestines are and not get any nutrients out of it.
 
Like I said in my previous post, having been on a similar dosage of tramadol, laxatives are pretty nil as long as the drug has a grip on your bowels. If you adjust your dosage schedule so that your body has plenty of time to clear it all out while you sleep, when you wake up your chances of having a BM will be greatly increased. You should increase your fiber intake drastically with benefiber (soluble, tasteless fiber) or fiber one bars (high fiber granola bars) or something like that. Compound this with a magnesium laxative or polyethylene glycol 3350 (miralax).

Load up on fiber and laxatives an hour or so before bed. Make sure your last tramadol dose is well before you go to bed, also. This should work for you, at least occasionally. It really helped me when I was on tramadol, after a lot of pain and suffering lol.

Of course you should be drinking pretty much nothing but water, and a lot of it, with all of these things. Especially if it's pretty hardcore. That's it for today's installment of poop-tips. Tune in next week.
 
I'm still not gonna eat 50,000 anti-diarrhea pills to get high, though lmao...If it takes that much to get high, it's not worth it. Just sounds like hardcore hepatic damage right there. If it's an opioid, it get's filtered through the liver, and taking however many of them 365 days a year just doesn't sound good lol.
 
I'm still not gonna eat 50,000 anti-diarrhea pills to get high, though lmao...If it takes that much to get high, it's not worth it. Just sounds like hardcore hepatic damage right there. If it's an opioid, it get's filtered through the liver, and taking however many of them 365 days a year just doesn't sound good lol.

Loperamide HCL is not known to be hepatoxic. All of these factors are tested in extreme doses (enough of a dose that would cause an overdose centrally)

The only outstanding issue is whether high consumption of certain binders will affect the liver and kidneys. These binders are also taken into account when the FDA approves a product. In my limited research (limited by the fact that I can only view abstracts in many cases) the only thing I've come across is adverse reactions to Lactose in generic formations of Loperamide in lactose-intolerant persons or animals (specimens).

You know, in hospitals they use laudanum (now called "tincture of opium") in some severe cases (i.e., life-threatening while in-patient) of diarrhea -- such as from malaria or AIDS. Just because it's labelled "anti-diarrhea" does not give it a negative connotation. Many codeine products in the 1970s were labelled cold medicine/cough medicine. I wonder of codeine got the same level of flack from the recreational drug community?

Here are the scientific facts about Loperamide, this is the document that medical professionals look at: http://www.imodium.com/images/imodium/pdf/ImodiumLoperimideFacts.pdf Note that brand name Imodium products available OTC (there is a prescription strength Imodium product) do not contain lactose, so this PDF did not look into the lactose consumption. This document also has non-pertinent information regarding another of Imodium's products that combines an anti-gas agent with Loperamide -- it clearly mentions which drug is referred to however. Just make note that simethicone is not in generic formations (that I've seen) with Loperamide.

Highly recommended read for everyone using it regularly -- it details its solubility, bioavailability, LD50, and other important factors.
 
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I'm still not gonna eat 50,000 anti-diarrhea pills to get high, though lmao...If it takes that much to get high, it's not worth it. Just sounds like hardcore hepatic damage right there. If it's an opioid, it get's filtered through the liver, and taking however many of them 365 days a year just doesn't sound good lol.
...
 
I dont have much time to tell my whole story,but i really hope i am believed in wht im saying,cause with all my being iam telling the truth,and if you want to here more details,email me and ill help.So,to begin,I have a very important gov. job,real talk,i do.Before this job i did opiates,from perc 10s to oxy20s 40s then80s,old school type>the 80s.My rx addiction was started around 17 going on 18,i had a crooked doc who charged 40$ for 40 pills,again started with percs till i got to OC 80s,and i got script in my name thn my moms thn my dads every 5 days for like 4-5 years,i chewed up 3-4 80s every 2hrs till i passed out for the day,thn DEA got on doc,so doc said i can only give u perc 10s,wasnt enough.So i found heroin,snort for 3months thn shot for 3 months,in tht 6 months my life was nomore,so i went to methadone clinic for 3 years,i was in and out rehabs 4 times during my whole addiction,anyway,got off the methadone,and truly away from the life and people,but down the road my mom passed away,and my girl at the time didnt know how to be their for me for this happening,so i went back to heroin for like 3 more years,thn i got out of it again and left for my new job,and i took me away,for awhile,so to the thread.I found the loperamid info and was like this aint real,well i couldnt be sick and do my job,now my addiction i picked back up in my job wasnt as bad as whn i was home,but it was still bad enough tht if i didnt have anything,i couldnt function,and i had to go to work everyday.So i tried the lopes,12pills nothing,24 pills took away the sickness,48 pills is my level off where i am so happy everyday,i truly couldnt believe how great it worked,i want to explain more but its alot,but it works,and i shit 3 to 4 times a week,sometimes my stomach will hurt but not often,and ive been taking 48 pills everymorning for about 9 months now,i am not lieing 9 months,i am scared tht over this much time tht my guts could be messed up,i plan on soon going to get checked out some how without telling wht ive been doing.Sometimes i get a high,but i really dont know how to descibe it,it is an opiate high,but different,then sometimes i dont get tht feeling,but i sleep amazing and have the most wildest dreams from it,i can work play be around people and not think twice.I REALLY STRESS if your a docter reading this,some kind of research needs to be done, i know there probly is,but i havnt been able to find much at all,i will tell everything about my use to help,but im telling you it really is a wondser to me how this shit works.But a heavy tolerance it might not work as well.I got to go,but any questions i will happily answer,People iam not lieing,but if you try be careful,work your way up till you notice the sicknerss gone,and like i said sometimes you will get a high,but for people looking for the high,you probly wonte like it,lopes is more for the person tht really wants to stay away from the life and live life,and for job reasons cant be on methadone or subs.ANy Q. hit me up please,i do want to help.
 
Thanks for that link, Timland. Lots of good information ripe for the absorbing.

Also, Doug2113, I've never used loperamide to get high. I have used it however to abort withdrawals, and for that it works as promised. That's the point we're trying to make, that it is an opiate with opiate effects. Not very recreational in my opinion by any means, but it truly is a godsend when you're in the depths of hellish withdrawal.
 
Thanks for that link, Timland. Lots of good information ripe for the absorbing.

Also, Doug2113, I've never used loperamide to get high. I have used it however to abort withdrawals, and for that it works as promised. That's the point we're trying to make, that it is an opiate with opiate effects. Not very recreational in my opinion by any means, but it truly is a godsend when you're in the depths of hellish withdrawal.

I dunno, man. I have taken insane amounts, and got nothing but sever stomach cramps, and constipation while in the worst dt's imaginable, that is actually worse than the constipation I had taking the methadone at the time!!! To be fair, I have a monster tolerance, and back then, it was beyond fucking ridiculous. But could my tolerance really be that much higher than you people taking the loperamide that it would have NO EFFECT, not even helping dt's a little bit, when I was convinced it would? I would think not, though my dt's are worse than what most go through.
 
It's saved my ass more than once. To be fair I don't have a methadone mantainence-level tolerance either, but 20-30 mg of loperamide reduced my withdrawal symptoms by probably 75% in the span of a couple of hours, but I've had results from as low as 10mg as well, albeit not as excellent ones.

What kind of 'insane' amounts are we talking here? 50mg? 100mg? 200mg?

The constipation is certainly worse than most other opiates, but it was manageable for me. Worth it for being able to function, in my opinion. Haha.
 
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You could always chase the loperamide down with a bottle of magnesium citrate lol.
 
After trialling a strip of Prilosec 40mgs (one dose at a time) one hour prior to dosing Loperamide vs not using Prilosec I've come to the conclusion that it makes ZERO difference. YMMV, but I recommend not using Prilosec unless you actually do need it, as it has no appreciable effect it seems.
 
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It's saved my ass more than once. To be fair I don't have a methadone mantainence-level tolerance either, but 20-30 mg of loperamide reduced my withdrawal symptoms by probably 75% in the span of a couple of hours, but I've had results from as low as 10mg as well, albeit not as excellent ones.

What kind of 'insane' amounts are we talking here? 50mg? 100mg? 200mg?

The constipation is certainly worse than most other opiates, but it was manageable for me. Worth it for being able to function, in my opinion. Haha.

I have finished a 96 count bottle of generic loperamide within 24 hours, after starting with 50mg, dosing up 25mg more a ouple of hours after that, and then I said fuck it, and ate 30-40 MORE mg. But before I could go any further, my stomach started hurting. At first it was bearable, but it got worse, and once the last "dose" kicked in, I literally fell to the floor with paralyzing stomach cramps. The cramps didn't last too long, but my stomach hurt all the way through the next day(I can't sleep in WD's, as can't many people) and I never got ANY effect, whatsoever.
But as I said, I had a pretty high tolerance, and "OTC methadone" can't really compare to real methadone :)

I won't say your experience isn't real, I won't say that at all, in fact if the massive dose hadn't fucked my stomach up, I might have got SOMETHING out of it, though with my tolerance and severe DT's, I probably wouldn't have noticed a faint amount of relief.

And what does "YMMV" mean, Timland????????????????????????????????????????????????????

(meant to say I"almost finished" the 96 count bottle, as there we're a good 20 or so pills left.)

Also, even though I have my doubts about it's use as a WD aid, I can say beyond a shadow of ANY DOUBT that it is a good potentiator. I am not sure if it's becuase it is taking up space in the PNA, allowing your DOC to attach more molucles in the CNS, or something completely different, but moderate doses of loperamide make pretty much every opiate(excluding Bupe, of course) more intense, even more so than my beloved P450 inhibitors, which mainly lengthen the high.

Though even a moderate dose such as 6-8mg can help, I prefer to take around 20mg, to seal the deal. Let me tell you:
Methadone, oxycodone, and loperamide= heaven...
 
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Your Mileage May Vary.

Cramps could be from lactose, or it could be from the magnesium stearate which some do have an intolerance to.
 
Your Mileage May Vary.

Cramps could be from lactose, or it could be from the magnesium stearate which some do have an intolerance to.

That makes sense, I am mildly lactose intolerant, like roughly half the nation. I say mild because it is not severe as some people have, as I can consume cheese and ice cream, but actual milk is hard for me to get down(partly because I hate it) and more than a few ounces gives me a stomach ache, and sometimes even my beloved milkshakes can make me cramp if I drink too much.

Brian242 says
"Why is this still open?"

Because it is an interesting subject. Believe me, I have tried loperamide and got no results. But as mentioned above, I have a pretty heroic tolerance, and am almost certain the generic loperamide had lactose. But honestly if you don't find an OTC opiate with potency comparable to fentanly, that unfortunately cannot cross the blood brain barrier slightly interesting, whether you are a skeptic or not(like myself), than I honestly don't know what to say, except that this post couldn't possibly be bothering you, can it?
Also, it may not have helped me, but I actually know 2 H-attics(A mother and son,ironically) that swear by it, and I do keep a bottle around to potentiate full agonists with, on the rare occasion I don't IV, which is usually if I have methadone.
 
Hmm... You're right Lorne667. I didn't know about the potency of Fent or as a potentiator, but I knew it didn't cross the BBB. I guess i'll have to try it as a potentiator.
 
Hmm... You're right Lorne667. I didn't know about the potency of Fent or as a potentiator, but I knew it didn't cross the BBB. I guess i'll have to try it as a potentiator.

Yes, you should, but I've noticed that it only works if you take your dose ORALLY. Since I usually IV, I don't get to do it often, but as I said, it potentiates the hell outta methadone!!!

Also, it is not only as potent as fentanly, but has a very long half life, not much shorter than methadone itself.Unfortunately, it doesn't cross the BBB, so all that potential goes to waste :(

And I hope I didn't sound like a prick,man. I just know that people are going to see Immodium" and think it is ridiculous, without realizing that there is SOMETHING to the discussion, granted, it may not be much, but it's something. But in any case I am glad you took it well, and do try it, but remember, even though it may not cross the BBB, it is EXTREMELY potent, and so you are basically filling the opoid receptors in your stomach with a fentanly like drug that lasts 18 hours, but never gets you high. Basically, be prepared not to shit for 24 hours.
 
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