1. Melatonin
Description: Powerful antioxidant and a good sleep regulator
Dosage: 3mg sublingual post usage
2. Quercetin
Description: one of my favourite supplements inhibits enzyme CYP3A4, one a few enzymes responsible for the breakdown of MDMA, therefore potentiates MDMA. It exerts potent antioxidant activity and vitamin C-sparing action.
COMT Inhibitor
MAO-B Inhibitor
Dosage: One capsule, it’s wise to take with Vitamin C and/or with other antioxidants
3. Ascorbyl Palmitate
Description: Fat Soluble Vitamin C, lasts in the body a lot longer than normal vitamin C and it has better antioxidant properties
Dosage: 2000mg before Stimulant usage, it is advised to take it with food to enhance absorption
4. Milk Thistle
Description: Liver protecting supplement
Dosage: This is something you should take every day, it protects liver and restores it back to optimal health
5. Magnesium
Description: Reduces tolerance, Reduces jaw clenching whilst on MDMA and a overall muscle relaxant
Dosage: Everyday, 400mg
Note: Take chelate form of magnesium, none of the bullshit Oxide and other forms, they have terrible bio-availability.
6. Piracetam
Description: Another must get supplement, Modulates Serotonin and dopamine receptors, Enhances neurotransmission, Anti Oxidant, and also potentiates all stimulants. Makes your peak feel more clean
Dosage: 3200mg before stimulant and after
7. 5-HTP
Description: Precursor to Serotonin, increases serotonin levels
Dosage: 100mg x 3 post MDMA usage. Do not take it for more than 5 days in a row without dopamine precursors; otherwise it will cause depletion of dopamine – take with Green Tea
8. Green Tea extracts (EGCG)
Description: Another MUST GET supplement, VERY POWERFUL antioxidant, 200x more than Vitamin E. COMT Inhibitor which is one of the many enzymes responsible for the breakdown of MDMA. It is also a Decarboxylase inhibitor so it potentiates 5-htp and l-dopa
Dosage: Take with 5-htp so that 5-htp gets converted to serotonin in the brain and not in your gut, also before MDMA usage for potentiation and powerful antioxidant activity. Dose: 300mg of 40% EGCG extract
9. Vitamin C
Description: Anti oxidant
Dosage: 3000mg pre stimulant, 2000mg x 4 the next day. Take with EGCG and other anti oxidant
10. Deprenyl (Selegiline) (Mod note: You should NEVER mix an MAOI of any kind with MDMA but if you choose to use selegiline, make sure that you keep the dose below 5mg and that it is NOT that patch! Higher doses of Selegiline inhibit MAO-A as well and Selegiline is an irreversible MAO inhibitor meaning that once you use it, you have to wait for the enzyme to be replaced which takes up to 14 days. Be extremely careful with this as MAOIs and serotonin releasers is a combination well known for causing serotonin syndrome!)
Description: MAO-B inhibitor, not to be mistaken with ordinary MAOI's. it reduces cardiovascular toxicity, inhibits formation of peroxides in the brain. inhibits Dopamine metabolism. it may revive dead neurons in the brain. it may reverse neurotoxicity. It is even said it inhibits neurotoxicity from METH use.
Dosage: 2.5mg with food 1 hour before MDMA usage
11. Taurine
Description: General cellular health supplement, its a amino acid as well as a neuromodulator. Its a neuroprotector and regulates Calcium ions in the brain. its also a great anti-anxiety agent
Dosage: 1500mg before food a day
12. L-Theanine
Description: Glutamate receptor antagonist (AMPA, Kainate, NMDA), Dopamine releaser, Enhances focus, mood, and memory. reduces anxiety and nervousness
Dosage: 200mg per dose. good relaxant post mdma usage and pre
13. Acetyl-L-Carnitine Arginate
Description: NGF agent (nerve growth factor) stimulates the growth of neurites in the brain. it MAY reverse neurotoxicity and protect the brain from peroxynitrites (very potent neurotoxin that causes harsh oxidative stress)
Dosage: 2000mg a day of Ordinary Acetyl-l-Carnitine, or 800mg of Arginate form. its a good idea to have a combination of both as they work together
Note: Arginate is fairly expensive but it is a lot more potent and beneficial, otherwise you can just get the normal Acetyl-L-Carnitine
14. L-Dopa
Description: like 5-htp, its a direct precursor to Dopamine, a lot better than tyrosine.
Dosage: Take in morning before food with Green Tea, 200mg. its a good idea if your taking 5-htp at night to have this the following morning for optimal neurotransmitter levels.
Note: DO NOT TAKE for atleast 24 hours after MDMA usage as the excess dopamine may get trapped by SERTS that have been activated by MDMA and cause oxidative stress.
15. Inositol
Description: Regulates serotonin, Calcium Ion concentration control, which means controls build up of tolerance to amphetamines. also increases REM activity during sleep
Dosage: 1000-2000mg a day, usually before sleep.
16. Fish Oil
Description: Contains Omega 3 fatty acids that has numerous health benefits, one of which supports vascular health, dopamine transmission and etc
Dosage: depending on what brand you got, since they all have different concentrations. i take about 4-6 fish oil capsules a day (EPA:400mg DHA:200mg in each capsule) with food
17. Alpha lipoic acid
Description: Very effective antioxidant, passes through the blood brain barrier more efficently that most other Anti oxidants.
Dosage: Pre: 300mg, during: 600mg, post: 300mg x 3
Note: there are many forms, such as stablized ones that cost a fortune. up to you which you pick. they all work the same except one would be more potent then the other. - the dosage above is for the ordinary Alpha lipoic acid
18. Tianeptine (Selective Serotonin Reuptake Enchancer)
Description: a very unique Anti depressant that works opposite to SSRI's, instead of inhibiting the uptake of serotonin back to the pre-synapse it enhances it. meaning it increases your overall serotonin storage rather than aiding its depletion that SSRI's do...
Dosage: recommended 12.5mg 3x a day, there is been a report with someone taking 240 tablets a day for several months and was later successfully detoxified.
Note: this will probably work better than anything to increase your "true" serotonin levels long term and restore them to optimal levels. this is the most worth while drug to take but its precription only. apparently its legal to import without.
19. Ginkgo
Description: Days after MDMA usage, elevated levels of MAO activity in the brain are present, this further causes depletion of Serotonin and also Noradrenaline, thus lethargy and loss of motivation,
Ginkgo works as mild MAO Inhibitor as well as increases blood flow to the brain
Dosage: 200mg x 2 daily Post MDMA anf following days
20. Methyl Donors (Betaine, aka TMG, aka TriMethylGlycine)
Description: Increased Methylation via Methyl donors have shown to increase neurotransmittor levels, Methylation aids in the production of SAM-e, which is the building block of serotonin, dopamine and noradrealine.
Dosage: 500-1000mg Daily
Cat's Claw
Description: Powerful MAO-B inhibitor, similar to Quercetin and Deprenyl
Dosage: 2 capsule of NOW brand "5000" formula of Cat's Claw 1 hour before MDMA usage and 2 after.. though dosage has to be modified if your taking Quercetin and/or Deprenyl with it
GABA Powder
Description:Promotes Relaxation, Ease sleep days after MDMA usage or just in general. It Inhibits overstimulation caused by excessive neurotransmitter release.
Dosage: 1-2g when needed
will keep updating .....
Antioxidant Note
Remember, Antioxidants always work together synergetically. Once a antioxidant supplement does its job, it turns to the oxidated form which becomes useless. in presence of another antioxidant, it is recycled....
Sources
[1]Guide to Neurotransmitter depletion
- http://neuroassist.com/Depletion1.htm
- Explains everything about how giving precursors to neurotransmitters depletes other neurotransmitters and how the only way to correct neurotransmitter levels is to take both dopamine and serotonin precursors and not just the one
- also explains how SSRI's cause long term depression and serious depletion of serotonin
[2]Green Tea Polyphenols: Novel Irreversible Inhibitors of Dopa Decarboxylase
- http://www.sciencedirect.com/scienc...serid=10&md5=1848aae719e010d9f17f770b73b9e269
[3]Dr Bob, View on Magnesium and amphetamine tolerance.
- http://www.dr-bob.org/babble/20081016/msgs/858452.html
[4]Information on Acety-l-Carnitine and health benefits
- http://www.vrp.com/articles.aspx?ProdID=art2256&zTYPE=2
- http://www.ncbi.nlm.nih.gov/pubmed/19015003
will keep updating sources too
Description: Powerful antioxidant and a good sleep regulator
Dosage: 3mg sublingual post usage
2. Quercetin
Description: one of my favourite supplements inhibits enzyme CYP3A4, one a few enzymes responsible for the breakdown of MDMA, therefore potentiates MDMA. It exerts potent antioxidant activity and vitamin C-sparing action.
COMT Inhibitor
MAO-B Inhibitor
Dosage: One capsule, it’s wise to take with Vitamin C and/or with other antioxidants
3. Ascorbyl Palmitate
Description: Fat Soluble Vitamin C, lasts in the body a lot longer than normal vitamin C and it has better antioxidant properties
Dosage: 2000mg before Stimulant usage, it is advised to take it with food to enhance absorption
4. Milk Thistle
Description: Liver protecting supplement
Dosage: This is something you should take every day, it protects liver and restores it back to optimal health
5. Magnesium
Description: Reduces tolerance, Reduces jaw clenching whilst on MDMA and a overall muscle relaxant
Dosage: Everyday, 400mg
Note: Take chelate form of magnesium, none of the bullshit Oxide and other forms, they have terrible bio-availability.
6. Piracetam
Description: Another must get supplement, Modulates Serotonin and dopamine receptors, Enhances neurotransmission, Anti Oxidant, and also potentiates all stimulants. Makes your peak feel more clean
Dosage: 3200mg before stimulant and after
7. 5-HTP
Description: Precursor to Serotonin, increases serotonin levels
Dosage: 100mg x 3 post MDMA usage. Do not take it for more than 5 days in a row without dopamine precursors; otherwise it will cause depletion of dopamine – take with Green Tea
8. Green Tea extracts (EGCG)
Description: Another MUST GET supplement, VERY POWERFUL antioxidant, 200x more than Vitamin E. COMT Inhibitor which is one of the many enzymes responsible for the breakdown of MDMA. It is also a Decarboxylase inhibitor so it potentiates 5-htp and l-dopa
Dosage: Take with 5-htp so that 5-htp gets converted to serotonin in the brain and not in your gut, also before MDMA usage for potentiation and powerful antioxidant activity. Dose: 300mg of 40% EGCG extract
9. Vitamin C
Description: Anti oxidant
Dosage: 3000mg pre stimulant, 2000mg x 4 the next day. Take with EGCG and other anti oxidant
10. Deprenyl (Selegiline) (Mod note: You should NEVER mix an MAOI of any kind with MDMA but if you choose to use selegiline, make sure that you keep the dose below 5mg and that it is NOT that patch! Higher doses of Selegiline inhibit MAO-A as well and Selegiline is an irreversible MAO inhibitor meaning that once you use it, you have to wait for the enzyme to be replaced which takes up to 14 days. Be extremely careful with this as MAOIs and serotonin releasers is a combination well known for causing serotonin syndrome!)
Description: MAO-B inhibitor, not to be mistaken with ordinary MAOI's. it reduces cardiovascular toxicity, inhibits formation of peroxides in the brain. inhibits Dopamine metabolism. it may revive dead neurons in the brain. it may reverse neurotoxicity. It is even said it inhibits neurotoxicity from METH use.
Dosage: 2.5mg with food 1 hour before MDMA usage
11. Taurine
Description: General cellular health supplement, its a amino acid as well as a neuromodulator. Its a neuroprotector and regulates Calcium ions in the brain. its also a great anti-anxiety agent
Dosage: 1500mg before food a day
12. L-Theanine
Description: Glutamate receptor antagonist (AMPA, Kainate, NMDA), Dopamine releaser, Enhances focus, mood, and memory. reduces anxiety and nervousness
Dosage: 200mg per dose. good relaxant post mdma usage and pre
13. Acetyl-L-Carnitine Arginate
Description: NGF agent (nerve growth factor) stimulates the growth of neurites in the brain. it MAY reverse neurotoxicity and protect the brain from peroxynitrites (very potent neurotoxin that causes harsh oxidative stress)
Dosage: 2000mg a day of Ordinary Acetyl-l-Carnitine, or 800mg of Arginate form. its a good idea to have a combination of both as they work together
Note: Arginate is fairly expensive but it is a lot more potent and beneficial, otherwise you can just get the normal Acetyl-L-Carnitine
14. L-Dopa
Description: like 5-htp, its a direct precursor to Dopamine, a lot better than tyrosine.
Dosage: Take in morning before food with Green Tea, 200mg. its a good idea if your taking 5-htp at night to have this the following morning for optimal neurotransmitter levels.
Note: DO NOT TAKE for atleast 24 hours after MDMA usage as the excess dopamine may get trapped by SERTS that have been activated by MDMA and cause oxidative stress.
15. Inositol
Description: Regulates serotonin, Calcium Ion concentration control, which means controls build up of tolerance to amphetamines. also increases REM activity during sleep
Dosage: 1000-2000mg a day, usually before sleep.
16. Fish Oil
Description: Contains Omega 3 fatty acids that has numerous health benefits, one of which supports vascular health, dopamine transmission and etc
Dosage: depending on what brand you got, since they all have different concentrations. i take about 4-6 fish oil capsules a day (EPA:400mg DHA:200mg in each capsule) with food
17. Alpha lipoic acid
Description: Very effective antioxidant, passes through the blood brain barrier more efficently that most other Anti oxidants.
Dosage: Pre: 300mg, during: 600mg, post: 300mg x 3
Note: there are many forms, such as stablized ones that cost a fortune. up to you which you pick. they all work the same except one would be more potent then the other. - the dosage above is for the ordinary Alpha lipoic acid
18. Tianeptine (Selective Serotonin Reuptake Enchancer)
Description: a very unique Anti depressant that works opposite to SSRI's, instead of inhibiting the uptake of serotonin back to the pre-synapse it enhances it. meaning it increases your overall serotonin storage rather than aiding its depletion that SSRI's do...
Dosage: recommended 12.5mg 3x a day, there is been a report with someone taking 240 tablets a day for several months and was later successfully detoxified.
Note: this will probably work better than anything to increase your "true" serotonin levels long term and restore them to optimal levels. this is the most worth while drug to take but its precription only. apparently its legal to import without.
19. Ginkgo
Description: Days after MDMA usage, elevated levels of MAO activity in the brain are present, this further causes depletion of Serotonin and also Noradrenaline, thus lethargy and loss of motivation,
Ginkgo works as mild MAO Inhibitor as well as increases blood flow to the brain
Dosage: 200mg x 2 daily Post MDMA anf following days
20. Methyl Donors (Betaine, aka TMG, aka TriMethylGlycine)
Description: Increased Methylation via Methyl donors have shown to increase neurotransmittor levels, Methylation aids in the production of SAM-e, which is the building block of serotonin, dopamine and noradrealine.
Dosage: 500-1000mg Daily
Cat's Claw
Description: Powerful MAO-B inhibitor, similar to Quercetin and Deprenyl
Dosage: 2 capsule of NOW brand "5000" formula of Cat's Claw 1 hour before MDMA usage and 2 after.. though dosage has to be modified if your taking Quercetin and/or Deprenyl with it
GABA Powder
Description:Promotes Relaxation, Ease sleep days after MDMA usage or just in general. It Inhibits overstimulation caused by excessive neurotransmitter release.
Dosage: 1-2g when needed
will keep updating .....
Antioxidant Note
Remember, Antioxidants always work together synergetically. Once a antioxidant supplement does its job, it turns to the oxidated form which becomes useless. in presence of another antioxidant, it is recycled....
Sources
[1]Guide to Neurotransmitter depletion
- http://neuroassist.com/Depletion1.htm
- Explains everything about how giving precursors to neurotransmitters depletes other neurotransmitters and how the only way to correct neurotransmitter levels is to take both dopamine and serotonin precursors and not just the one
- also explains how SSRI's cause long term depression and serious depletion of serotonin
[2]Green Tea Polyphenols: Novel Irreversible Inhibitors of Dopa Decarboxylase
- http://www.sciencedirect.com/scienc...serid=10&md5=1848aae719e010d9f17f770b73b9e269
[3]Dr Bob, View on Magnesium and amphetamine tolerance.
- http://www.dr-bob.org/babble/20081016/msgs/858452.html
[4]Information on Acety-l-Carnitine and health benefits
- http://www.vrp.com/articles.aspx?ProdID=art2256&zTYPE=2
- http://www.ncbi.nlm.nih.gov/pubmed/19015003
will keep updating sources too
Last edited by a moderator:
