Well cimetidine will certainly increase bioavailability and half-life significantly but unfortunately you'll have to sacrifice some potency.
Give it a go, you're the only one who can evaluate its benefit to you. I would suggest you do the same with hydroxyzine because as I mentioned before its inhibition of liver enzymes is mild, it has its own analgesic mechanism, and could add to the sedation of oxycodone therefore increasing relaxation.
I'm not even sure how to respond to that. When someone called you out on amphetamine and MDMA serotonin syndrome, I provided the study to back your statement up. My aim is not not to prove you wrong, but to state the facts. This is why it's called drug discussion, not LaCsters experiences.
Here is someone else that agrees and is objective:
http://www.drugs-forum.com/forum/showthread.php?t=103590
I can find you several on bluelight pointing out the same facts.
I said depotentiate.
They decrease oxycodone-oxymorphone conversion by inhibiting 2D6/3A4 respectively. Please try and read and comprehend accurately as I won't repeat my logic again.
From df:
Give it a go, you're the only one who can evaluate its benefit to you. I would suggest you do the same with hydroxyzine because as I mentioned before its inhibition of liver enzymes is mild, it has its own analgesic mechanism, and could add to the sedation of oxycodone therefore increasing relaxation.
Chrome, this forum is not about telling people they are wrong, so next time when you want to think only about yourself, remember this isn't your thread
I'm not even sure how to respond to that. When someone called you out on amphetamine and MDMA serotonin syndrome, I provided the study to back your statement up. My aim is not not to prove you wrong, but to state the facts. This is why it's called drug discussion, not LaCsters experiences.
Here is someone else that agrees and is objective:
There is a common misconception among opioid users in this forum, other forums, & on the street, and that is: a good potentiator for opiates or opioids is cimitidine (more commonly known as tagamet).
The theory is that because cimitidine inhibits the CYP3A4 liver enzyme which is responsible for breaking down many opiates/oids into inactive metabolites (noroxycodone, norhydrocodone, etc..) that the opiate/opioid in question will have an increased effect & longer duration. While this is true to a certain extent, there is a vital peice of information regarding the pharmokinetics of cimitidine & it's enzyme inhibition that is widely overlooked by the opiaficionados out there.
See not only does cimitidine inihibit the CYP3A4 enzyme it is also an inhibitor of a wide range of isozymes of the P450 enzyme system. In addition to the CYP3A4 enzyme, cimitidine (tagamet) also inhibits CYP1A2, CYP2C9, CYP2C19, CYP2E1, & most importantly the CYP2D6 liver enzyme.
The opiates/opioids codeine, hydrocodone, & oxycodone are all CYP2D6 substrates meaning they all involve metabolism by the enzyme CYP2D6 on some level. Specifically codeine as many, if not all, of us well know metabolizes into morphine via CYP2D6, hydrocodone is metabolized into hydromorphone via CYP2D6, & oxycodone is metabolized into oxymorphone via CYP2D6.
These metabolites I have just mentioned are all much stronger than codeine, oxycodone, & hydrocodone alone thus they are NOT good candidates for cimitidine (tagamet) potentiation unlike many benzodiazapines.
Hope that helps...Remember kids, eat your grapefruit.
http://www.drugs-forum.com/forum/showthread.php?t=103590
I can find you several on bluelight pointing out the same facts.
How the fuck do they potentiate oxy,
I said depotentiate.
you sir are quite wrong. You obviously don't know what your are talking about because oxycodone is highly.metabolized through cytochrome 450 and tagmet definitely increases the duration of oxy
They decrease oxycodone-oxymorphone conversion by inhibiting 2D6/3A4 respectively. Please try and read and comprehend accurately as I won't repeat my logic again.
From df:
SWIM agrees that cimitidine IS in fact a potentiator to a degree but also an inhibiter of greater levels of euphoria that could be acheived with the combination of a CYP3A4 only inhibitor and a CYP2D6 inducer.
Because Cimitidine is a potent CYP3A4 inhibitor it does potentiate opiates in that it increases the duration through inhibiting the enzyme responsible for eliminating the drug through inactive metabolites (CYP3A4) but because it has the potent ability to drastically reduce the amount of morphine created by codeine, hydromorphone created by hydrocodone, and oxymorphone created by oxycodone via CYP2D6 inhibition it isn't the most suitable potentiator for opiates.
And actually the amounts of active and significantly more potent metabolites of codeine, hydrocodone, and oxymorphone are definately significant especially with codiene which is basically euphorically inactive without being converted into morphine via CYP2D6.
Here are the percentages for the afformentioned CYP2D6 substrates.
Hydrocodone- -Hydromorphone= a maximum yield of 25%
Oxycodone- -Oxymorphone= average yield of 15%
Codeine- -Morphine= average yield of 10%
So with a CYP2D6 inducer thrown into the mix these conversions become significantly higher, conversly, a CYP2D6 inhibitor such as tagamet (cimitidine) would lower the yields of the more potent metabolites created via CYP2D6
I hope that makes sense.
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