This is a case of someone who OD'd on Loperamide and died. I found a more official version of the case before but can't seem to find it now. I remember "multiple massive organ failure" or something being part of it. I'm leaving this shit alone. It being so uncommon means that there's little information out there about the side effects and i've experienced at least 9 different ones personally. I keep picturing my insides liquefying. I have enough problems w/o a hospital stay with no insurance and having to say "yeah i was...uh, i was taking excessive amounts of Immodium...yeah Immodium...no really, it can get you high..."
1.2mg/L of blood... no wonder they died. When you have 100x the theraputic level of an opiate in you and you get drunk, what do you expect?
Aw man, I took a bunch of pills, did some hoodoo shit and got fuuuuuuuuuucked mate, better than fentanyl- Loperamide is my drug of choice!
Sorry, weird spasms. The keys are all right next to eachother. I found that 10mg of loperamide morning/night really helped make my last round of withdrawals (the first time I've used lope for w/d's) manageable. It was still unpleasant, but it helped reign the dopesickness back into regular-sickness territory, I'm not sure if it actually improved my w/d's or if it just did an extremely good job at taking the edge off the stomach/digestive problems.
At a certain point though, I found, it's actually better to stop taking them- I went from shitting molten lead in withdrawal to having a human metabolism and being painfully constipated- more pain in no way helped my opiate cravings. Methadone ain't gone nothing on loperamide constipation, nothing!
Iv'e been taking (roxie's, hydro's) over 30 year, at times copious amounts...
The poppy head tea blows everything outta' the water you just need basic chemistry to do it the correct way Iv'e heard people that have tried it & dont get it..."BASIC CHEMISTRY"
You did not experience"precipitated" withdrawls...
Originally Posted by Kev70
I'm trying to taper off opiates using lope...it was real moderate use but enough to give me mild w.d which I don't mind except I just started school and need to be on point
Basically what's the half life of lope? I've heard some people say 9-14hrs and others as much as 3 days. I took 36mg 4 days ago and am planning on taking another dose now...basically I just don't want to redose with lope already in my system thus increasing my levels and possibly prolonging w.d
idunno really,, but i found that Opiate withdrawl will even be gone afer i took 2x20mg today, it took WD symptoms are mostly gone.
Again kicking from H af afetr tapering with fentanyl.
Just tired, but i popped 50Mg oxa, 2mg Xanax and 30 mg of Dormicum.
I shall come back to tell you if and how i slept.
But i believe i won' tremember anything in the morning.=D
and that''s worth a lot, when withdrawling from opiates
But i need some sleep...8(
The abstract quoted apparently comes from:
Originally Posted by NomNomNom
J Anal Toxicol. 2005 Oct;29(7):750-4.
Tissue distribution of loperamide and N-desmethylloperamide following a fatal overdose.
Sklerov J, Levine B, Moore KA, Allan C, Fowler D.
Division of Forensic Toxicology, Office of the Armed Forces Medical Examiner, 1413 Research Blvd., Rockville, Maryland 20850, USA.
I'd be interested in seeing this article and doing a write-up on the case for my blog. As you said, there's not a lot of information available on loperamide abuse or overdose. (And every time you try starting a conversation on the subject, you get jokes about bowel movements and the like, which are not particularly amusing and even less helpful).
i never got high off this shit. OH and i TRIED BELIEVE ME.
I once even tried to add an acetyl- group to it in hopes it would help cross the BBB. I did this by isolating the acetic acid from vinegar and cooking the two together till the acid was evaporated. Snorted prolly 2mg worth(all im willing to snort) and nothing
Chew up 24 pills with a glass of white grapefruit juice and 60mg DXM. Wait a couple hours. You'll then know why people swear by this drug. Don't let the fact that its marketed as an anti-diarrhea med fool you. After all, right there on the lable insert, one of the first side effects listed is "marked drowsiness" along with a couple other classic opioid effects. It works. Just because it embarrasses you to try it or to admit its efficacy doesn't mean its any less effective. Combined with DXM it really has a pronounced effect and is a very worthwhile addition to your opioid WD kit. Don't let your fear of being mocked get in the way of utilizing a very valuable tool for WDs, as well as for providing a moderate, sort of complex, opioid high that can last for many hours on end and provide relief for moderate WDs. It works, period.
Glad to see this topic still going. Some progress is being made. Soon LOPE might be the next big thing for the government to take away.
It does work, just not well.
I'll try the GFJ method one day.
Still very happy with codeine and its cheaper.
I've found that lope can push codeine a bit higher.
Fun time we live in.
Free world. Your free to do as you please, you just might end up in a free prison though.
I dunno what to say but...
I quite frankly have trouble believing anyone who say's they have gotten ANYTHING from this shit, much less a high. I tried when I was in DT's, believe me, NOTHING. Zilch. Nada. I took it and, badda bing badda bang, didn't shit for 2 days(in withdrawal!) and very, VERY painful when I did. I wouldn't reccomend this for anyone, unless you enjoy the placebo effect, or have an insanely low tolerance, or better yet, a !compromised Blood-brain-barrier!
WHich brings up a good point: with all the shit that can get you high, you would think that if your BBB blocks something, it DOES NOT need to be there.
But then again, I have a heroic tolerance, that even a compromised liver hasn't seemed to bring down. So maybe I am just an angry junky asshole!!!
I doubt it, but maybe...
Originally Posted by NomNomNom
This has been my experience as well. Tolerance seems to build fast for Loperamide. I've been taking it for several months now exclusively and recently someone I know who quit pods gave me his stock and I couldn't feel anything off roughly 40 large heads finely ground and washed twice. However, when I waited to the peak of WD off Lope (which rivals precipitated WD for me at its peak) and took pod tea 20 were enough with one wash (I did not completely withdraw off Loperamide).
I am mainly interested at this point on the effects of longterm ingestion of high amounts of the binders in Loperamide. I know one of them is lactose which obviously isn't a big deal unless lactose intolerant. One is Magnesium Stearate -- Not sure what the verdict on this is.
At some point I will taper, just don't feel like it yet. Definitely don't quit this stuff cold turkey if you are dependent it will be HELL. I've WDed off pods with not much of an effort before, and I've experienced naltrexone induced precipitated withdrawal twice, and Loperamide definitely is on par with the latter when cold turkeying off extreme doses for me. Thankfully, its available at so many places and so affordable so the possibility of an unforeseen withdrawal is minimal.
Edit to add: At higher end doses (well into 3 digits mg) I experience blurred vision on occasion, and vertigo -- more vertigo than from a typical opioid/opiate. Both symptoms recede when coming down from plateau.
Some have mentioned in the past that crushing them may yield more potency. For me it makes no difference swallowing them whole or crushing except in the time it takes to comeup. Crushed its within an hour to reach plateau otherwise its closer to 2 hours.
Some TMI regarding BMs for those that need to know:
I get "pinecone" bowel movements if I do not take corrective action. For others that do -- generic Miralax / Polyethylene glycol in NORMAL indicated doses daily makes my BMs completely comfortable though does not increase the frequency.
Helped me alot with withdrawal but for me I didnt feel much anything but some of my wd pains going away
To me it just seems ridiculous (and extremely painful) to take anti-diarrhea medication to get high. I have to take a bunch of pills because of chronic pain, and the digestive side effects aren't fun at all. My shits are easily 1.5 times the size of porn stars' dicks, they're hard as a boulder, and it takes every last bit of strength to get them out. But I guess to each his own. If having a torn asshole and hemorrhoids is what get's you off, be my guest.
Effectively countered with stool softeners. In some cases my BMs have been softer than normal despite taking gargantuan doses of Loperamide. There were even times I had to reduce my Miralax dose because I was going too often. Also, like central mu receptors one develops a tolerance peripherally as well.
Originally Posted by Doug2113
But yes, it is indeed extremely painful to have such a BM, it almost brought me to tears once. Thankfully I have taken preventative action since.
And not any more ridiculous than dissolving some brown powder from south of the border and IVing it ;) (No offense to H users, I am not asserting that I am superior because I don't IV or anything like that, just using it as an example). The euphoria from opiates/opioids whether they are labelled anti-diarrheal or not is worth the pitfalls for many, obviously.
If something gets you very euphoric through mu-opioid agonization (and I know Lope does not do so for everyone) given its accessibility and its cheapness compared to illicit opis does it matter what its FDA approved indication is? I am able to get noddy daily if I so choose without even putting a serious dent in my income and I am on unemployment right now.
The funny thing about this is that most people will have this same knee jerk reaction when first learning about loperamide. Myself included. "ANTI POOP PILLS? LOL BRO U DUMB." These kinds of responses are expected, but I urge you to read more into this with an open mind.
Originally Posted by Doug2113
It's really awesome that loperamide is so easily accessible. Truly a poor mans methadone.
Loperamide IS a potent, peripherally acting opiate. A full mu-agonist. Meaning that is a potent opiate, but since it does not cross the blood brain barrier but in trace amounts, won't bring on the opiate effects you and I know and love.
However, taken in huge amounts, loperamide can and will induce intoxication. I've never used it in that high of a dosage, only 26 milligrams or so max for withdrawal abortion. Works amazingly. It removed about 80% of my physical withdrawal symptoms. I was able to function, and of course poop(eventually.)
Loperamide is not a fucking joke. It is a no bullshit opiate. The constipiation is similar to that of other full agonists, if not a little longer in duration thanks to its extremely long half-life. It can be countered like all opiate induced constipation: kinda sorta. Large amounts of water, stool softeners and a high fiber intake are all things you should already be trying to counter opiate-stipiation.
Try not to strain so hard either, you take tramadol, right? Tramadol constipiation is MUCH worse for some reason than most other forms of opiate constipation I've dealt with. But there are options, you know?
Try switching the dose times of your pills so that when you wake up in the morning you have minimal tramadol left over in your system, so that you can try to go to the bathroom before you take your morning dose. I was prescribed 6 tramadol a day awhile back and that was the only way I ended up being able to cope with the pluggage.
Don't bag on lope if you don't know your dope.
Poetic, but the only thing I've found to truly help me is a saline lax. Which completely reverses it. I've tried stimulant lax.which didn't work, tried stool softeners, hell, even did a suppository which didn't really yield the results I needed. So it seems I can remain plugged up or I can let all my food go down the slip and slide that my intestines are and not get any nutrients out of it.
Like I said in my previous post, having been on a similar dosage of tramadol, laxatives are pretty nil as long as the drug has a grip on your bowels. If you adjust your dosage schedule so that your body has plenty of time to clear it all out while you sleep, when you wake up your chances of having a BM will be greatly increased. You should increase your fiber intake drastically with benefiber (soluble, tasteless fiber) or fiber one bars (high fiber granola bars) or something like that. Compound this with a magnesium laxative or polyethylene glycol 3350 (miralax).
Load up on fiber and laxatives an hour or so before bed. Make sure your last tramadol dose is well before you go to bed, also. This should work for you, at least occasionally. It really helped me when I was on tramadol, after a lot of pain and suffering lol.
Of course you should be drinking pretty much nothing but water, and a lot of it, with all of these things. Especially if it's pretty hardcore. That's it for today's installment of poop-tips. Tune in next week.
I'm still not gonna eat 50,000 anti-diarrhea pills to get high, though lmao...If it takes that much to get high, it's not worth it. Just sounds like hardcore hepatic damage right there. If it's an opioid, it get's filtered through the liver, and taking however many of them 365 days a year just doesn't sound good lol.
Loperamide HCL is not known to be hepatoxic. All of these factors are tested in extreme doses (enough of a dose that would cause an overdose centrally)
Originally Posted by Doug2113
The only outstanding issue is whether high consumption of certain binders will affect the liver and kidneys. These binders are also taken into account when the FDA approves a product. In my limited research (limited by the fact that I can only view abstracts in many cases) the only thing I've come across is adverse reactions to Lactose in generic formations of Loperamide in lactose-intolerant persons or animals (specimens).
You know, in hospitals they use laudanum (now called "tincture of opium") in some severe cases (i.e., life-threatening while in-patient) of diarrhea -- such as from malaria or AIDS. Just because it's labelled "anti-diarrhea" does not give it a negative connotation. Many codeine products in the 1970s were labelled cold medicine/cough medicine. I wonder of codeine got the same level of flack from the recreational drug community?
Here are the scientific facts about Loperamide, this is the document that medical professionals look at: http://www.imodium.com/images/imodiu...imideFacts.pdf Note that brand name Imodium products available OTC (there is a prescription strength Imodium product) do not contain lactose, so this PDF did not look into the lactose consumption. This document also has non-pertinent information regarding another of Imodium's products that combines an anti-gas agent with Loperamide -- it clearly mentions which drug is referred to however. Just make note that simethicone is not in generic formations (that I've seen) with Loperamide.
Highly recommended read for everyone using it regularly -- it details its solubility, bioavailability, LD50, and other important factors.
Originally Posted by Doug2113
I dont have much time to tell my whole story,but i really hope i am believed in wht im saying,cause with all my being iam telling the truth,and if you want to here more details,email me and ill help.So,to begin,I have a very important gov. job,real talk,i do.Before this job i did opiates,from perc 10s to oxy20s 40s then80s,old school type>the 80s.My rx addiction was started around 17 going on 18,i had a crooked doc who charged 40$ for 40 pills,again started with percs till i got to OC 80s,and i got script in my name thn my moms thn my dads every 5 days for like 4-5 years,i chewed up 3-4 80s every 2hrs till i passed out for the day,thn DEA got on doc,so doc said i can only give u perc 10s,wasnt enough.So i found heroin,snort for 3months thn shot for 3 months,in tht 6 months my life was nomore,so i went to methadone clinic for 3 years,i was in and out rehabs 4 times during my whole addiction,anyway,got off the methadone,and truly away from the life and people,but down the road my mom passed away,and my girl at the time didnt know how to be their for me for this happening,so i went back to heroin for like 3 more years,thn i got out of it again and left for my new job,and i took me away,for awhile,so to the thread.I found the loperamid info and was like this aint real,well i couldnt be sick and do my job,now my addiction i picked back up in my job wasnt as bad as whn i was home,but it was still bad enough tht if i didnt have anything,i couldnt function,and i had to go to work everyday.So i tried the lopes,12pills nothing,24 pills took away the sickness,48 pills is my level off where i am so happy everyday,i truly couldnt believe how great it worked,i want to explain more but its alot,but it works,and i shit 3 to 4 times a week,sometimes my stomach will hurt but not often,and ive been taking 48 pills everymorning for about 9 months now,i am not lieing 9 months,i am scared tht over this much time tht my guts could be messed up,i plan on soon going to get checked out some how without telling wht ive been doing.Sometimes i get a high,but i really dont know how to descibe it,it is an opiate high,but different,then sometimes i dont get tht feeling,but i sleep amazing and have the most wildest dreams from it,i can work play be around people and not think twice.I REALLY STRESS if your a docter reading this,some kind of research needs to be done, i know there probly is,but i havnt been able to find much at all,i will tell everything about my use to help,but im telling you it really is a wondser to me how this shit works.But a heavy tolerance it might not work as well.I got to go,but any questions i will happily answer,People iam not lieing,but if you try be careful,work your way up till you notice the sicknerss gone,and like i said sometimes you will get a high,but for people looking for the high,you probly wonte like it,lopes is more for the person tht really wants to stay away from the life and live life,and for job reasons cant be on methadone or subs.ANy Q. hit me up please,i do want to help.
Thanks for that link, Timland. Lots of good information ripe for the absorbing.
Also, Doug2113, I've never used loperamide to get high. I have used it however to abort withdrawals, and for that it works as promised. That's the point we're trying to make, that it is an opiate with opiate effects. Not very recreational in my opinion by any means, but it truly is a godsend when you're in the depths of hellish withdrawal.