N&PD Moderators: Skorpio | thegreenhand
Merck Index said:Cocaine
pKa (15°) 8.61
Base:
One gram dissolves in 600 ml water, 270 ml water at 80°, 6.5 ml alcohol, 0.7 ml chloroform, 3.5 ml ether, 12 ml oil turpentine, 12 ml olive oil, 30-50 ml liquid petrolatum. Also sol in acetone, ethyl acetate, carbon disulfide.
HCl:
One gram dissolves in 0.4 ml water; 3.2 ml cold, 2 ml hot alcohol; 12.5 ml chloroform. Also sol in glycerol, acetone. Insol in ether or oils.
Pseudo
pKa 9.22
Base:
Sparingly sol in water. Freely sol in alc or ether.
HCl:
(at 25° ) One gram dissolves in 0.5ml water; 90.9ml chloroform; 3.6ml ethanol.
Eph
Base:
Sol in water, alcohol, chloroform, ether.
HCl:
Freely sol in water; sol in alcohol. Practically insol in ether.
do an Acetone wash (caffeine gone)
then freebase
wash the bases with water (ephedrine gone)
dry completely
sal out of acetone using 1:1 HCL/ethanol
do final acetone wash