Warm - you are unlikely to have a seizure.
However, opiates and alcohol just don't mix.
They do not feel right together, and it should only take you one use to figure this out.
Alcohol works upon the gaba receptors in the brain, opiates have their own sub-class of dopamine receptors.
The FEW times I have tried this combo, I took the opiate first.
Tramadol is a WEAK antagonist of the opiate receptor and it takes a good TWO hours to peak.
Once it does, it lasts MUCH longer than hydrocodone. 100mg Tramadol should keep you buzzed for 4 hours.
I highly recommend waiting for the tramadol to take full effect before drinking ANY alcohol.
Once this happens, you may find that you won't even finish the 40.
Drink it slowly, and I promise you will dislike the combination rather quickly.
It can upset your stomach and give you a very uneasy headache.
If you drink the alcohol slowly, you can stop and back off before its too late.
If you slam the whole damn thing, you will probably throw up.
Alcohol is poison, my friend.
Opiates are NICE and clean - as long as you don't OD or take long-term.