You'd need to take an insulin syringe and measure out a very small, precisely known amount, and work up from micrograms until you find the right dose.
Personally I just love alpha2 adrenoreceptor agonists, I'd DEFINITELY jump on it, or on xylazine (a rhino tranq of similar nature) if I ever get the chance.
Although DO be lying down when taking it, and take TINY, volumetrically diluted quantities, work up from an inactive level until you find your dosage. Don't keep an open container of the substance around, because when you nod out, and you probably will, you don't want to knock it over. And this stuff, WILL knock you out if you don't dose very very low.
It sounds lovely to me.
As for with opioids, be EXTREMELY careful and titrate both of them up, with the detomidine especially, very carefully dosed, and incremented until the ideal combination dose of your opioid and the detomidine is found.
I haven't tried detomidine, medetomidine, xylazine or romifidine, nor 4-NEMD, but I'd love to. Have wanted to for a long time, but I do have scripts for both tizandine and clonidine. I find tizanidine to have the more powerfully sedating and relaxing effects of the two, although clonidine is far more potent by weight, in micrograms rather than milligrams ( I take 20-24mg tizanidine a day to suppress the muscle spasm left with the nerve damage caused by a failed leg operation, and even at 4mg plugged or intranasally, when I first got on it, that would have me nodding in and out, feeling lovely and relaxed, whilst clonidine doesn't seem to be as recreational. Perhaps because I'm autie and I take the clonidine to block sensory overloading and adrenal storms (catecholamine type, not corticosteroidal, although its still foul enough)
I'd hit this stuff alright. Fuck yeah I would. But very, very fucking carefully. I'd try maybe 0.5ug first, to see how that affects you, never taken it, but clonidine is dosed starting at 25ug per tablet. I wonder how much difference might be due in the subjective effects to different alpha2 adrenoreceptor subtype selectivity and how much is due to agonism at imidazoline receptor subtypes.
CAREFUL with this, very very very careful, and as I said, and I'll say it again, work it up from a dose that is not active, 500 nanograms maybe if I were to get any, and that would be my start point, maybe as low as 50-100 nanograms, before working up to 1 microgram, then 2ug, etc. until you find what you are after.
I DO think alpha2 adrenergic autoreceptor agonists are recreational, tizanidine/zanaflex sure is, to me. Goes nice with opioids, even 2mg insuflated of tizanidine had me nodding onto my computer keyboard for hours. Feels fucking lovely though.
Also, do NOT suddenly 'cold turkey' stop these types of drug, not if using regularly, which rx human meds aside like tizanidine, clonidine, on script can be the case. A SEVERE hypertensive crisis and tachycardia will result, as well as terrifying anxiety, sweating bullets, and this can actually be very dangerous. So use this sparingly if you use it.
I wish I had some, I reckon yer' a lucky sod. Lucky bastard getting to try detomidine before me!
Damn I am gonna have to get some of this, and some xylazine too, romifidine as well if I can get it. Also there is another in common use, lofexidine, for H detox support, to help stop the adrenergic storm, and calm the user, soothe the akathisia etc.
But don't use daily, just once in a while (running it up could go a few steps over a day given its short action of course. But other than that don't use this daily, just as an occasional treat)
I absolutely LOVE tizanidine, especially plugged, and with opioids. Clonidine isn't as good subjectively although for my autie sensory and physical overloading, it does work wonders too. Plugging tizanidine has even let me sleep for a while in opioid WD. 'Tis nice stuff. Be REALLY fucking careful with detomidine.
Also, don't be a goober and try using it undiluted. Dilute in ethanol and then take your dose measured in a syringe, diluted with water and plug or drip into the nose. Thats how I'd do it, after diluting it so I could start at less than a microgram until I reached active level.
These drugs are not psychologically dependence forming but a physical habituation and corresponding rebound effect, a physical withdrawal can definitely happen with alpha2aR agonists if taken chronically rather than once in a while. I've felt this from tizanidine after my former housemate, the devilbitch borderline PD gorgonslut OCD cunt from the bowels of perdition had been hiding my meds from me, forcing me to withdraw. The rebound from these drugs is fucking nasty as, and it could well be dangerous.
And DO keep that powerful orthostatic hypotension in mind, even tizanidine can knock you out cold if you take it and then rise from a recumbent position to standing without starting off bent forwards as if performing a japanese bow, and SLLOOOOOOWWWLY raise yourself to standing, whilst holding on to something like a sofa, so as to fall, if you should fall due to orthostatic hypotension, then there be something soft and harmless to hit on the way back down when you black out, if the dose be too large.
And again...you lucky bastard, you
This thread is making me want to toss a couple of hundred mikes of clonidine and 2-4mg tizanidine in with my next opioid shot. lol.
