I have been on seroquel myself and had a similar experience, although not nearly as bad from what it sounds like. You’re right-- it’s truly a miserable medication if it doesn’t work for you.
We don't know much about seroquel's mechanism of action and there really isn’t any research out there about seroquel’s potential for physical dependence apart from a shaky publication on rodents. But considering how it interacts with other depressants and the fact that we take daily doses, one can assume it’s very likely a month’s-use will lead to withdrawal symptoms if you go cold turkey. From what I’ve read, seroquel has the highest affinity for H1 receptors (histamine), which means a physical dependence would likely be established from daily dosage. So titrating up/ tapering down is the best way to minimize symptoms. If you have any seroquel left, then I’d suggest tapering back down via smaller doses (a pill cutter would be helpful). If you don’t/ don’t want to take any, then I’d suggest a small dose of benadryl or some other antihistamine. If you want to avoid going back to the daily doses, even for the purpose of managing symptoms briefly, you could also just have them handy to take as needed. Other depressants may help too (e.g., benzos), but I’d guess that the antihistamines specifically would be your best bet/ the easiest to acquire. A few other things that could help with nausea would be cannabis, dramamine, or ginger.
As for what I did-- it’s a little hard to recall the timeline since it was awhile ago and, due to the bad side effects I was having from the drug, it’s a little hazy when those ended and the withdrawal symptoms began. At the time I didn’t know much about pharmacology, but I can say that cannabis did help alleviate them. That was just an instinctive go-to for me, however cannabis does actually help with nausea. Other than that, it was mostly just a lot of sleep, reminding myself to regularly drink water/ginger ale and eat, and forcing myself to interact with a few friends so I wouldn’t drown in total isolation in my bed (the earlier side effects had similarly kept me in bed for a little while beforehand). I know that may be obvious, but I can’t stress enough how important it is to remember to take care of yourself when things feel truly terrible.
My bad for the long-winded reply, but I hope that helps!
