This could be subjective or placebo, but I've always found there to be a limited amount of synergy when I combine Gabapentinoids. If I say, take both Gabapentin (Neurontin) and Pregabalin (Lyrica) in the same sitting, I experience much more potent effects. I don't have any research to back up this statement, but just be aware. These drugs are practically defined by their safety, but some definitely experience convulsions when they dose to high with Gabapentinoids.