Arylcyclohexylamines varyingly possess NMDA receptor antagonistic,[11][12] dopamine reuptake inhibitory,[13] and μ-opioid receptor agonistic[14] properties. Additionally, σ receptor agonistic,[15] nACh receptor antagonistic,[16] and D2 receptor agonistic[17] actions have been reported for some of these agents. Antagonism of the NMDA receptor confers anesthetic, anticonvulsant, neuroprotective, and dissociative effects; blockade of the dopamine transporter mediates stimulant and euphoriant effects as well as psychosis in high amounts; and activation of the μ-opioid receptor causes analgesic and euphoriant effects. Stimulation of the σ and D2 receptors may also contribute to hallucinogenic and psychomimetic effects