gingerbaker
Bluelighter
- Joined
- Dec 3, 2013
- Messages
- 69
First of all, yes, I've searched the forums and interwebs and done quite a bit of reading. That being said, I still have a few questions regarding kratom for treating chronic pain.
1. What is the best strain for chronic pain? I've seen Red Borneo and Bali and am curious if there is a difference between the two.
2. What is the longest lasting strain that can still reasonably used for analgesia? I'm thinking that there is a strain that might be long lasting but not necessarily the most analgesic-oriented.
3. How is Kratom metabolized? I know there are active metabolites, but is it a pro-drug situation like Tramadol, for instance (where the metabolites are more active/potent)?
4. What are some not-so-obvious [legal] potentiators (obviously GFJ, cimetidine, 1st gen anti-histamines would be good ones I'm assuming but I guess it sort of depends on the answer to #3)?
5. With kratom "powder" (finely ground leaves), why do people claim that the capsules slow down absorption?
6. What are good ways to increase bioavailability and what is the bioavailability of sublingual and oral ROAs?
7. Does consuming kratom on a stomach with some food in it just slow absorption or does it actually lessen the effects?
8. Regarding "boosting"; is it true that one must wait a few hours if the dose is not adequate? I've read that you can't really bump up the effects a notch or two by taking a little bit more say, half an hour after taking the 1st dose. That just doesn't seem logical but I can't find any info on the pharmscokinetics of kratom.
9. I've also read that tolerance doesn't really develop as rapidly or extensively as opioids. Obviously it develops to a certain extent and there is some risk of dependency but could someone quantify this? For example, if you start off with taking 5grams of X every 5hrs, what would the tolerance be in a month?
As always, thank you everyone for your help!
1. What is the best strain for chronic pain? I've seen Red Borneo and Bali and am curious if there is a difference between the two.
2. What is the longest lasting strain that can still reasonably used for analgesia? I'm thinking that there is a strain that might be long lasting but not necessarily the most analgesic-oriented.
3. How is Kratom metabolized? I know there are active metabolites, but is it a pro-drug situation like Tramadol, for instance (where the metabolites are more active/potent)?
4. What are some not-so-obvious [legal] potentiators (obviously GFJ, cimetidine, 1st gen anti-histamines would be good ones I'm assuming but I guess it sort of depends on the answer to #3)?
5. With kratom "powder" (finely ground leaves), why do people claim that the capsules slow down absorption?
6. What are good ways to increase bioavailability and what is the bioavailability of sublingual and oral ROAs?
7. Does consuming kratom on a stomach with some food in it just slow absorption or does it actually lessen the effects?
8. Regarding "boosting"; is it true that one must wait a few hours if the dose is not adequate? I've read that you can't really bump up the effects a notch or two by taking a little bit more say, half an hour after taking the 1st dose. That just doesn't seem logical but I can't find any info on the pharmscokinetics of kratom.
9. I've also read that tolerance doesn't really develop as rapidly or extensively as opioids. Obviously it develops to a certain extent and there is some risk of dependency but could someone quantify this? For example, if you start off with taking 5grams of X every 5hrs, what would the tolerance be in a month?
As always, thank you everyone for your help!