about_time
Greenlighter
- Joined
- Jun 12, 2013
- Messages
- 5
I have conducted a couple studies on this over the counter medication. My test rat is still alive and kicking, fortunately.
I will lay out what I have done, what works and what the possible reasons are for successful results I have experienced.
Loperamide Extraction
72 2mg(144mgs) Loperamide pills were crushed and placed in a small glass cup.
The resulting powder was soaked in 30-50ml Isopropyl Alcohol.
50-100mg of Citric Acid was stirred into the solution to increase Loperamide solubility.
Cup was placed in the microwave for 10-15 seconds to increase solubility by heating.(this may not need to be done)
The solution was stirred once more and left to sit for a few minutes or until the fillers settled to the bottom and the liquid layer became a very light green.
The liquid layer was decanted and filtered through a coffee filter.
The resulting liquid was then evaporated on a hot plate until the Isopropyl Alcohol could not be smelled on the plate.
What you have here is 95-99% pure Loperamide Citrate.
I prepared the entire content into a water-based IV solution and injected 1/3 of the solution(roughly ~45mg).
45mg Loperamide IV felt like 15mg of morphine or 2mg of Dilaudid(Hydromorphone)
Loperamides initial rush feels about like a cross between Dilaudid and Morphine.
Something I noticed, was that the Loperamide seemed to be much more potent when Citric Acid is added during the extraction process.
Either the Citric Acid helps extract a more pure product, or the Citric Acid may be aiding the Loperamide with crossing the BBB.
4-Acetyl-Loperamide Preparation:
The other 2/3 of the Loperamide Citrate IV Solution(~90mg in .3cc's [30 units]) was squirted into a spoon/can-bottom.
3-4 drops of Acetic Anhydride was added to solution.
Solution was brought to a boil and swirled until all the water and AA was completely evaporated and could not be smelled in the can.
The resulting product was light brown in color and very translucent.
Water was added to the spoon and the solution was drawn up through a cotton.
~90mg 4-Acetyl-Loperamide Citrate was injected.
The rush was reminiscent of 4mg Dilaudid or 30mg Morphine. The Acetylated analogue seemed to have a more euphoric feel than the 4-Hydroxy isomer(Loperamide).
I believe this needs more testing and study.
Miosis of the pupils was very mild if any. I don't get miosis from morphine either..
I am a recovering IV Opiate addict and know the difference between an IV Opiate Rush and placebo..
Let me know if anyone has any questions.
As for why this is working and apparently crossing the BBB... My guess is either loperamide is active in IV doses around 30-40mgs or the Citric Acid is helping carry the molecule across and the Citrate salt is possibly more lipophilic? The 4-Acetyl-Loperamide Citrate may also cross the BBB more easily than Loperamide.
I will lay out what I have done, what works and what the possible reasons are for successful results I have experienced.
Loperamide Extraction
72 2mg(144mgs) Loperamide pills were crushed and placed in a small glass cup.
The resulting powder was soaked in 30-50ml Isopropyl Alcohol.
50-100mg of Citric Acid was stirred into the solution to increase Loperamide solubility.
Cup was placed in the microwave for 10-15 seconds to increase solubility by heating.(this may not need to be done)
The solution was stirred once more and left to sit for a few minutes or until the fillers settled to the bottom and the liquid layer became a very light green.
The liquid layer was decanted and filtered through a coffee filter.
The resulting liquid was then evaporated on a hot plate until the Isopropyl Alcohol could not be smelled on the plate.
What you have here is 95-99% pure Loperamide Citrate.
I prepared the entire content into a water-based IV solution and injected 1/3 of the solution(roughly ~45mg).
45mg Loperamide IV felt like 15mg of morphine or 2mg of Dilaudid(Hydromorphone)
Loperamides initial rush feels about like a cross between Dilaudid and Morphine.
Something I noticed, was that the Loperamide seemed to be much more potent when Citric Acid is added during the extraction process.
Either the Citric Acid helps extract a more pure product, or the Citric Acid may be aiding the Loperamide with crossing the BBB.
4-Acetyl-Loperamide Preparation:
The other 2/3 of the Loperamide Citrate IV Solution(~90mg in .3cc's [30 units]) was squirted into a spoon/can-bottom.
3-4 drops of Acetic Anhydride was added to solution.
Solution was brought to a boil and swirled until all the water and AA was completely evaporated and could not be smelled in the can.
The resulting product was light brown in color and very translucent.
Water was added to the spoon and the solution was drawn up through a cotton.
~90mg 4-Acetyl-Loperamide Citrate was injected.
The rush was reminiscent of 4mg Dilaudid or 30mg Morphine. The Acetylated analogue seemed to have a more euphoric feel than the 4-Hydroxy isomer(Loperamide).
I believe this needs more testing and study.
Miosis of the pupils was very mild if any. I don't get miosis from morphine either..
I am a recovering IV Opiate addict and know the difference between an IV Opiate Rush and placebo..
Let me know if anyone has any questions.
As for why this is working and apparently crossing the BBB... My guess is either loperamide is active in IV doses around 30-40mgs or the Citric Acid is helping carry the molecule across and the Citrate salt is possibly more lipophilic? The 4-Acetyl-Loperamide Citrate may also cross the BBB more easily than Loperamide.
