If either one of these materials are tried on their own at separate dates, then their respective effects usually proceed with positive and profound results. In combination, or closely following one another, their respective effects have less mentally tangible resolution without the backdrop of normal consciousness. Put simply. You surprise your head with one material, your head is still recovering its feed back loops and compensatory whatnot. You gobble another material of perhaps different active mechanism. Because you are already mentally and physiologically off of the launch pad so to speak, the second material will likely not be as vivid as it would be alone. I think that expectation plays a strong part. At baseline one experiences purer anticipation and excitement as the substance makes itself known to you against blank canvas.
Otherwise, points to consider, have metabolic pathways been activated by material 1 that more effectively process such substances? Or, are all the enzymes so busy cleaning up after the first material, that the second one gets loiter around for longer?
There's lots of complex chemical binding data to wade through. I'm no science boffin, but there are many levels on which cross tolerance makes intuitive sense. Psychologically, and in terms of simple biology. As a layman I love to read what is described regarding the roles 5ht receptor subtypes etc. The more I do though, the less clearly deterministic the whole thing becomes. Sometimes a phenomenon can be better grasped on the Macro scale rather than Micro. It's rather like a fractal. The closer one focuses in on a particular detail, you realise to truly understand its significance requires a whole supporting background of other scientific knowledge and understanding.
On the whole I have found the cross tolerance between 2CB and empathogens to be more of a synergy really. The original Pihkal recipe was a 2cb chaser following MDMA, as to empower creative processing of insight gained during the earlier phase. I've had some good moments that way. I prefer now to use medium/profound dose of 2CB at T.00 followed by empathogen once I've become accustomed to the 2CB. In the same way that tryptamines are slightly shinier subjectively than phens, I sometimes like to start with a 4Sub tryptamine before overlaying an empathogen. It lets one get extremely far out, and yet still take yet another step off the edge, while maintaining a reasonably stiff upper lip. Hanging on in quiet desperation is the English way. It's not so bothersome with a big smile wrapped across your face.
The way around psychological tolerances might be to apply something with a radically different dynamic. That would, for me, involve pulling out the DMT n pipe. It never disappoints me, whatever I've already imbibed. It usually occupies all of my conscious and unconscious awareness irrespective of however odd I'd thought things had become already.
Sorry I rambled. There's probably some crumbs of truth in there.
Peace - Pipp
