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benzohead29
28-03-2012, 15:26
last night i took 600mg tagamet 45 min prior to takin 12mg klonopin....i didnt notice many effects and partly attribute it to having eaten a very fatty chicken pasta alfredo last that night...

my question is, does white grapefruit juice or tagamet (cimetidine), both CYP450 liver enzyme inhibitors, potentiate klonopin better/more effectively? thanks,

appreciate educated answers as always

benzohead29
28-03-2012, 15:37
I've heard that taking cimetidine prior to benzo/opiate ingestion requires you to also take TUMS 15 min prior to dosins...why is that? arent they both antacids? They say it has something to with the cimetidine not being able to be properly absorbed and therefore wasted?

any thoughts?

tl;dr why do i need to take tums after taking tagamet to potentiate benzos?

NeighborhoodThreat
28-03-2012, 15:51
I wouldn't take the Tums. The reason Tagamet potentiates (some) benzos isn't because its an antacid, but because its a CYP450 liver enzyme inhibitor, which happens to be the enzyme that metabolizes clonazepam (and a few other benzos). When you inhibit the enzyme, it takes your body longer to get rid of (metabolize) the clonazepam...which is why the duration is increased so much with the clonazepam + Tagamet combination.

NeighborhoodThreat
28-03-2012, 15:54
I'm going to merge both your clonazepam potentiation threads together.

benzohead29
28-03-2012, 16:00
but i heard you need to take tums of some kind of antacid post-tagamet so your stomach doesnt run out of acid? that sound counterintuitive to me....thoughts?

Pjkt2501
28-03-2012, 16:34
I've never heard that. Tagamet doesn't have anything to do with the acidity of your stomach in terms of potentiation. It's liver enzyme clogging, to be blunt.

Tums / antacids are what's up for amphetamines.

benzohead29
28-03-2012, 17:11
White grapefruit juice contains three ingredients that clog the CYP450 set. However, it doesn't clog CYP2D6 too well. It strongly fucks with CYP3A4 nicely though

would you say that quote 'fucks' with CYP3A4 better than tagamet? or could i just take them together for maximum enzyme inhibition?

benzohead29
28-03-2012, 17:26
also im not sure if my mylan generic C M 15 2mg clonazepam pills can be SL'd so i'm debating parachuting them for quicker onset....any suggestions?

Geaux Tigers!
28-03-2012, 18:11
*AMATEUR PHARMACOLOGY VIEW, NOT REFERENCED, FROM MY MIND*

Sublingual dosing of clonazepam would increase maximum plasma concentration more efficaciously than PO pill powder.

Cimetidine binds to cytochrome P450 which decreases clearance of benzodiazepines which undergo oxidative metabolism, including clonazepam; I think any benzodiazepine not metabolized by glucuronidation would be potentiated with cimetidine.

The interaction is objectively significant but I'm not sure to what degree subjective effects would be present.

benzohead29
28-03-2012, 18:18
but can all clonazepam pills be taken sublingually? these are the ones i have:

http://www.drugs.com/imprints.php?action=search&imprint=m+c+15

Geaux Tigers!
28-03-2012, 18:28
They should degrade under your tongue, similar to suboxone pills. They won't degrade like wafers, but yes they can be used SL.

benzohead29
28-03-2012, 18:39
alright just SL'd 10 mg klonopin....with cimetidine and white gf juice taken prior....i swallowed a little bit of the pills but most of the pills dissolved under my tongue, which i dont understand how it works since theyre not water soluble, but oh well. if it works it works

kokaino
28-03-2012, 18:42
Actually, there is something better than GFJ and cimetidine for potentiating benzos (except the 3-hydroxy group of lorazepam, temazepam, lormetazepam, and oxazepam). The antibiotic drug clarithromycin (Biaxin) is a drug that is an extremely powerful inhibitor of the CYP3A4 enzyme. This is the enzyme most responsible (by far) for the metabolism of just about all opioids and benzodiazepines. It comes in 500 mg tablets, taking 2 tablets (so 1000 mg) about 45-60 minutes before ingesting a benzo or opiate of choice and it would greatly potentiate it as it raises the levels of the drug in the body and makes the drug last longer.

I have tried it and it works better than anything I have ever tried to potentiate benzos or my methadone with.

benzohead29
28-03-2012, 18:43
and also noob question, but does taking cimetidine and/or white gf juice delay the onset of the benzo? seems when ive taken benzos by themselves they come on quicker/faster

kokaino
28-03-2012, 18:49
and also noob question, but does taking cimetidine and/or white gf juice delay the onset of the benzo? seems when ive taken benzos by themselves they come on quicker/faster

No, GFJ or cimetidine have no effect on the onset of benzos, or at least they shouldn't.

benzohead29
28-03-2012, 18:51
k well i just sublingualed 10mg and parachuted 2 mg so 12mg in all...bout to have some fun

benzohead29
28-03-2012, 19:04
one last thing thing, i head rumour that SL'd benzos habve a longer onset but higher peak due to it bypassing first metabolism in the GI tract? true?

kokaino
28-03-2012, 19:35
What do you mean by SL'd benzos?

benzohead29
28-03-2012, 19:37
in short all kpins can be SL'd?

benzohead29
28-03-2012, 19:39
sublingualed (under the tongue) way of takingthem

kokaino
28-03-2012, 19:44
Yes, sublingual benzodiazepines have a quicker onset of effects, higher peak, but a shorter duration of effects. However, taking benzodiazepines meant for oral consumption sublingually will not produce the same effect. Most of it will just end up being swallowed, even if you think it has been fully absorbed sublingually. There are reasons why drug companies make sublingual tablets and oral tablets. There's a big difference between them.

benzohead29
28-03-2012, 19:45
so i'd just be better off swallowing or parachuting them?

kokaino
28-03-2012, 20:06
so i'd just be better off swallowing or parachuting them?

Yes. Parachuting them gets them working quicker.

I know when I parachute the contents of Restoril capsules, I get a benzo rush 10 minutes after I take them (sometimes I feel it even earlier). Normally, the taking the capsules don't kick in until about 30 minutes in.

benzohead29
28-03-2012, 20:15
but will i still get an effect off sublingualing these at all? i dissolved them completely under my tongue, plus parachuted 4 of them, so i'm up to 18 mg.....10mg were SL'd

will i get a benzo effect from subbing those? i know some klonopin are specifically made for sublingual but those that are not should still absorb and be effective still right?

heres the pill image

http://www.drugs.com/imprints.php?ac...imprint=m+c+15

benzohead29
28-03-2012, 20:27
Yes, sublingual benzodiazepines have a quicker onset of effects, higher peak, but a shorter duration of effects. However, taking benzodiazepines meant for oral consumption sublingually will not produce the same effect. Most of it will just end up being swallowed, even if you think it has been fully absorbed sublingually. There are reasons why drug companies make sublingual tablets and oral tablets. There's a big difference between them.

what do you mean by produce a diff effect

benzo bars
28-03-2012, 20:58
18mg is a lot man. Be careful. I always SL, Snort, or Parachute but usually SL, especially with Kpins because of the minty taste

kokaino
28-03-2012, 21:04
You'll get an effect, but it would be more akin to an oral dose than a sublingual dose. It won't have the peak of a true sublingual dose.

kokaino
28-03-2012, 21:05
18mg is a lot man. Be careful. I always SL, Snort, or Parachute but usually SL, especially with Kpins because of the minty taste

Snorting doesn't work. You actually lose a lot of drug trying to snort benzos.

benzo bars
28-03-2012, 21:47
Snorting doesn't work. You actually lose a lot of drug trying to snort benzos.
hmm really ? I never really snort em, i usually snort opiates more but I never noticed a difference

mygreenbic
31-05-2014, 04:40
I tend to take my klonopins sublingually and have been doing so for years, but I think they are causing me serious dental problems along with the sublingual daily suboxone. I am frequently constipated because of the various drugs Im on so do you think the pills will still work if I swallow them? Its funny, out of over a decade of taking benzo's Ive never really swallowed them whole. Even my temazepam. I would always parachute it. But the rest sublingual. Would just come naturally. I love the taste of xanax and klonopin. I get worried that if there is food in my stomach and or intestines that I will waste the pills .