I was just wondering how tolerance and dependence carries over between different kinds of opiates. For example if you took hydrocodone one day and oxycodone the next and hydromorphone the next...etc and so forth would this help diminish tolerance/dependence. Or does it not make a difference because they are essentially all effecting the same receptors in your brain. And just for the record I'm not planning on doing this, just curious.
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BDD Moderators: Keif’ Richards | negrogesic
Tolerance Across Varying Opiates
- Thread starter SawRED
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NeighborhoodThreat
Bluelight Crew
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It depends on the person, although most people I know have nearly 100% cross tolerance between opiates.
Some opiate conversion charts/tools ask for a "percentage" of "cross-tolerance". When computing dosages, I usually ignore this function.
You'll notice that tolerance between similar opiates (for example, the "codones": hydrocodone and oxycodone and codeine) and the "morphones" (hydromorphone, oxymorphone, morphine).
But yes, you are correct, they all work on the same receptors, but there are other factors in play here. If all opiates acted exactly the same, they would all feel exactly the same.
Some opiate conversion charts/tools ask for a "percentage" of "cross-tolerance". When computing dosages, I usually ignore this function.
You'll notice that tolerance between similar opiates (for example, the "codones": hydrocodone and oxycodone and codeine) and the "morphones" (hydromorphone, oxymorphone, morphine).
But yes, you are correct, they all work on the same receptors, but there are other factors in play here. If all opiates acted exactly the same, they would all feel exactly the same.