A new GBL synth (simple) method which is to date not perfected, has been detailed by a bee. This uses GABA as a starting material.
Presently this method does not produce a clean product, but it will likely bee perfected. Even in this impure state, the GBL is reported as being active.
This serves to illustrate one of the many possible routes to producing GHB or enzyme convertible substances, which will turn to GHB in the body i.e. 1,4, GBL etc.
Aside from impurities, I am still not convinced 1,4B is completely safe to take, despite literature to the contrary. However other G synthesis routes will be also likely to produce impurities.
If GHB was ever legalized, pharmaceutical companies would be very interested in developing an antagonist which would act something like naltrexone. G OD may then be reversible, and safe known doses would further reduce incidents of accidental overdose.