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phase_dancer
01-03-2003, 09:10
3,4-Methylenedioxymethamphetamine (Ecstasy) and Alcohol Interactions in Humans: Psychomotor Performance, Subjective Effects, and Pharmacokinetics
[quote]C ´ ANDIDO HERN ´ ANDEZ-L ´ OPEZ, MAG FARR ´ E, PERE N. ROSET, ESTHER MENOYO, NIEVES PIZARRO,
JORDI ORTU ˜ NO, MARTA TORRENS, JORDI CAM´I, and RAFAEL DE LA TORRE
ABSTRACT
3,4-Methylenedioxymethamphetamine (MDMA) is frequently consumed in association with alcohol. The effect of this combination in humans has not been previously investigated. Nine male healthy volunteers received single oral doses of 100 mg of MDMA plus 0.8 g/kg ethanol, 100 mg of MDMA, 0.8 g/kg of
ethanol, and placebo in a double blind, double dummy, randomized crossover trial. Measurements included psychomotor performance, subjective effects, and pharmacokinetics.
Plasma concentrations of MDMA showed a 13% increase after the use of alcohol, whereas plasma concentrations of alcohol showed a 9 to 15%decrease after MDMA administration. The MDMA-alcohol combination induced longer lasting euphoria and well being than MDMA or alcohol alone. MDMA reversed the subjective sedation induced by alcohol but did not reduce drunkenness feelings. MDMA did not reverse the actions of alcohol on psychomotor abilities. Combined use of MDMA and alcohol causes dissociation between subjective and objective sedation. Subjects may feel euphoric and less sedated and might have the feeling of doing better, but actual performance ability continues to be impaired by the effect of alcohol. Confirmation of these findings in further studies will be highly relevant in terms of road safety.
Full text pdf available here (http://jpet.aspetjournals.org/cgi/reprint/300/1/236.pdf)
Thanks to the direction pointing bee pHarmacist

pinkanga
01-03-2003, 10:03
Interesting. Ive always found that dropping after a few drinks allows the effects of the MDMA to be appreciated more. I always thought it was just due to the fact that the alcohol made you more relaxed and less tense. I wonder if this is the case, or if the 2 drugs actually enhance each others effects.

superbabydoc
02-03-2003, 15:10
Hasn't this study been out for some time? I'm sure it was posted in the News section when it was all fresh still. :) Anuhow, an interesting study nonetheless.