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  • AADD Moderators: swilow | Vagabond696

Seratonin Syndrome

Airwalk

Airwalk

Bluelighter
Joined
Feb 26, 2001
Messages
2,625
Couldn't find anything in the search engine. Anyway was wondering exactly (In medical terms) this is. ie had MAOI or SSRI anti-depressant and then dropped a pill? Not urgent just curious.
 
Here's a post from Medical Q&A which has some good information:
Possibly dumb seratonin syndrome question...
For other references, there are plenty of posts in Medical Q&A, and there are many off-site references of varying degrees of helpfulness.
BigTrancer
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Load universe into cannon. Aim at brain. Shoot.
 
I used to know a girl who took SSRI-s and popped she seemed ok i guess whenever she took em
ive never thought too much about it though....
"she seemed ok"
not much help i am i guess
sorry
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the secret to success is clean underwear and a good top hat
 
Umm... quick couple of points from things that I've read:
SSRI then MDMA: Supposedly limited to zero effect will be felt from MDMA.
MAOI then MDMA: Massively increased risk of "seratonin syndrome"
SSRI + 5-HTP: As above.
 
There's a REALLY REALLY simple solution to all these kind of questions.
TALK TO YOUR DOCTOR!
And if you can't talk to your doctor, go out and find one you CAN talk to. That might even mean getting a referral to a specialist such a psychiatrist or a psychologist.
They're not there to judge you or dob you in...
 
errmmm....scary thing is ask a doctor if they think 5htp is an effective postload from mdma, or wether there are not enuff active receptors to allow it to cross the blood-brain barrier, therefore rendering it useless, in which case is a placebo affect as good as any?? and they'll flat out stare at you and wonder what the fuck your on (and probably be able to guess
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) i know too many med students, and i also know quite a few doctors (out of uni for 1-4 years mostly) and i find it scary that they know flat fuck all about this shit.
if you really wanna know, ask a pharmacist or someone with a biomed sci. degree....
0.022c inc. gst, + b/f
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...got a place for watching that will paint pictures and colour lights...
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Exactly, you probably really need to talk to a specialist - the trainspotters of the medical world. Your GP (general practicioner) most likely has a fair understanding of this, but for a really detailed answer you need to go to someone who specialises in the specific area.
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Does anyone know where to find that article on clubbed.com on the girl who died after having two pills containing PMA?
I cant find it?
 
after being on a course of Zyban for about a month i noticed that you get rather mild to normal onset effects then zip all.......
but zyban is a low quality anti depressant
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the consciouness of self is the greatest hinderance to the correct execution of any physical action... u dont exist therefore there are no boundaries or limits
 
Stoners... The above link no longer works.
I'm trying to find out about seratonin syndrome.
Cheers.
 
Originally posted by babydoc_vic:
The reason SSRI's reduce the effects of MDMA is because they have a greater affinity for the reuptake transporter than MDMA does. This basically means the SSRI, which got there first, is able to hang on in the reuptake transporter even though MDMA wants to get in too. MDMA can't get in, and therefore can't work properly. This is explained in the dancesafe slideshow.
A MAOI on the other hand doesn't stop MDMA from doing it's job. It does it's job as normal, releasing lots of serotonin and dopamine. Normally, MAO breaks down these neurotransmitters. But if you are on a MAOI, the neurotransmitters can't get broken down. See this page at the slideshow. This excess of serotonin can lead to serotonin syndrome, and there have been a number of cases of this described. Here's one: A Case of MAO Inhibitor / MDMA Interaction: Agony After Ecstasy
That's a pretty simplistic explanation - if you want a more detailed one, someone else will have to provide it!
As for "learn more about brain chemistry before you start ranting like that", :) here's a good resource. Neuroscience for kids
It might be for kids, but I use it all the time. :)
^^ Good work babydoc... From serotonin syndrom and SSRIs.
Click to expand...
 
Everything you ever wanted to know about serotonin syndrome, see here.
[ 13 October 2002: Message edited by: babydoc_vic ]
 
Ok, a question from an oldskooler that hasn't been on here fore ages..
BABY DOC..
you said....
"The reason SSRI's reduce the effects of MDMA is because they have a greater affinity for the reuptake transporter than MDMA does."
But isn't the "effect" of mdma caused by the binding of the molecule to the receptors on the dedradite (SP?), not the reuptake transporter.?
I was under the impression that nuerotransmitters binding with the recepters is what gave the "effects" of the drug, and that the reuptake transporters were simply a method of "controlling" the amount of serotonin floating about in the synapse at any one time. And this was also how ssri's worked.. By blocking the reuptake (or blocking control of levels) of serotonin there is infact more serotonin to bind with the receptors on the dendradite (sp?)
Hence SSRI's been more prone to bond with reuptake transporters than serotonin makes MORE serotonin be availiable to bind with the receptors on the dedradite, hence increasing the "effects" of the drug ?
SO where have i gone wrong.?
Chem
 
Man I actually asked that question. I guess we that means even the most researched among us didn't know the answers at some point.
But just to let people know the information I recieved at the time was very valuable for the person I then gave the information to.
 
I just went to GNC to pick up some L-Tyrosene (unrelated I know) - The same person has served me the past few times I have been, I have told her about my 5-HTP supplament (I didn't say why of course) - she warned that the body can become addicted to it and warned about Serotonin Syndrome as well. I told her that I had read up about it and also mentioned some points from this thread (not mentioning bluelight)
Just thought I would let you all know that there are non-bluelighters out there who seem to know what they are talking about too.... even if they have never had 5-htp!
 
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