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View Full Version : 1,4/GBL/GHB and Asian glow/alcohol flush reaction



et0s
15-09-2010, 10:15
Some people especially asians have a malformed aldehyde dehydrogenase enzyme (ALDH2) (http://en.wikipedia.org/wiki/Alcohol_flush_reaction) which is responsible for turning acetaldehyde to acetic acid in the metabolism of alcohol, this deficiency results in medical side effects from excess acetaldehyde.

Here's a metabolic pathway pic (http://upload.wikimedia.org/wikipedia/commons/9/9f/GHB_metabolic_pathway.svg), I'm no pharmacologist so I can't tell much from it, except that some form of aldehyde dehydrogenase plays a part.

Is there anybody here with Asian flush who takes G?

raybeez
15-09-2010, 16:36
Some people especially asians have a malformed aldehyde dehydrogenase enzyme (ALDH2) (http://en.wikipedia.org/wiki/Alcohol_flush_reaction) which is responsible for turning acetaldehyde to acetic acid in the metabolism of alcohol, this deficiency results in medical side effects from excess acetaldehyde.

Here's a metabolic pathway pic (http://upload.wikimedia.org/wikipedia/commons/9/9f/GHB_metabolic_pathway.svg), I'm no pharmacologist so I can't tell much from it, except that some form of aldehyde dehydrogenase plays a part.

Is there anybody here with Asian flush who takes G?

The flush comes from the buildup of acetalydehyde (metabolic byproduct of alcohol).

atara
15-09-2010, 16:59
GHB is consumed in significantly smaller amounts than alcohol, so buildup of succinaldehyde is less of an issue.