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NortonJosh24
26-05-2010, 11:35
I am curious if there is a drug out there that can induce REM sleep? Mabey Ill go as far as to ask if there are any that can force REM sleep? I have a few questions..... Next is there any drugs that can induce a coma at any certain dose. Finally can cardiac arrest wake u from a coma or rem sleep?

This may not be the right forum but I hope it is. If it is not, I apologize ahead of time for my ignorance.

thank you
- Josh

TearItDown
26-05-2010, 11:53
Don't think anything can force REM sleep except lack of REM sleep. If you do one of those special sleeping schedules where you only sleep four hours a day, every time you sleep (nap, really) you are almost instantly thrown into REM sleep. The concept behind it is that you sleep a total of four hours a day, but all of it is REM sleep. It's weird, but people do it. My room mate tried to get the schedule down but he fucked up. They say if you do it correctly for 2 weeks your body becomes adjusted.

shulsd33
26-05-2010, 20:43
This is probably not what you are looking for, but it's a proof of concept: http://www.springerlink.com/content/u108p01773l88135/

"The effect of -Br on the sleep-wakefulness cycle was to increase REM sleep and to slightly decrease wakefulness or NREM sleep."

I don't think this is the same as forcing REM sleep, but it shows that there are drugs that can induce REM. Maybe someone who knows a bit more than I about this subject can continue?

any major dude
29-05-2010, 01:24
supposedly some constituents of Nymphaea caerulea (blue lotus) cause much more vivid dreams, though I don't think this is currently supported empirically. There are plenty of relatively cheap extracts available though, so if you wanted to test it out it wouldn't be difficult.

Maybe not exactly what you were looking for, but somewhat related.

mecaib
29-05-2010, 23:55
Mirtazapine is great for inducing REM activity. It's probably called REMeron for a reason ;)

TearItDown
30-05-2010, 02:28
Mirtazapine is great for inducing REM activity. It's probably called REMeron for a reason ;)

Have you taken it before? It's called remeron because it's supposed to put you to sleep. It'll knock you out. That isn't sleep. That's why insomnia is so hard to treat properly. Being knocked out is far different from sleeping, any true insomniac will tell you there is a HUGE difference.

someguy200
30-05-2010, 07:39
I don't know if I would say it forces REM sleep, but Cyproheptadine increases the amount of REM sleep.


J Pharmacol Sci. 2007 Feb;103(2):201-6. Epub 2007 Feb 8.

Effects of some H1-antagonists on the sleep-wake cycle in sleep-disturbed rats.

Tokunaga S, Takeda Y, Shinomiya K, Hirase M, Kamei C.

Department of Medicinal Pharmacology, Okayama University Graduate School of
Medicine, Dentistry and Pharmaceutical Sciences, Tsushima-naka 1-1-1, Okayama
700-8530, Japan.

The present study was undertaken to investigate the effects of some
H(1)-antagonists on the sleep-wake cycle in sleep-disturbed rats in comparison
with those of nitrazepam. Electrodes were chronically implanted into the frontal
cortex and the dorsal neck muscle of rats for the electroencephalogram (EEG) and
electromyogram (EMG), respectively. EEG and EMG were recorded with an
electroencephalograph. SleepSign ver. 2.0 was used for EEG and EMG analysis. The
total times of waking, non-rapid eye movement (non-REM), and rapid eye movement
(REM) sleep were measured from 10:00 to 16:00. Nitrazepam showed a significant
decrease in sleep latency, total waking time, and delta activity and an increase
in the total non-REM sleep time. A significant decrease in the sleep latency was
observed with diphenhydramine, chlorpheniramine, and cyproheptadine.
Cyproheptadine also caused a significant decrease in the total waking time and
increases in total non-REM sleep time, REM sleep time, slow wave sleep, and delta
activity, although no remarkable effects were observed with diphenhydramine and
chlorpheniramine. In conclusion, cyproheptadine can be useful as a hypnotic,
having not only sleep inducing-effects, but also sleep quantity- and
quality-increasing effects.

PMID: 17287588 [PubMed - indexed for MEDLINE]

Nexus298
30-05-2010, 14:09
Xyrem (Prescription GHB) is used for narcolepsy with cataplexy. It helps by giving the patient fuller sleep. Not sure if this is actually increasing REM sleep. Anyone know a bit more about this?

debaser
30-05-2010, 14:34
Yeah GHB (and GBL in my case) can produce vivid dreams and sometimes even lucid dreams if used correctly.
It can also cause a reversible "coma" at a slightly higher dose than your "sweet spot", ie it's very difficult to wake you up as long as the drug takes effect (usually a short period, 3 to 4 hours), but when it's over you just wake up normally, provided you didn't take really too much. I wanted to post this but wasn't sure it corresponds to the OP question, sort of.

Chips
30-05-2010, 16:00
Melatonine ? Google give some trials result showing recovery of REM sleep using melatonine.

P A
30-05-2010, 20:59
Given that REM sleep and the atonia that accompanies it involves near-total monoaminergic shutdown in key regions as a requisite for initiating the dream state, the rest of the experimental data follow intuitively, and the information therein could be easily acquired inductively. Following initiation of REM, the neuromodulatory roles of most amines take a back seat to cholinergic transmission, the blockade of which at the M2 muscarinic receptors (Benadryl, scopolamine) tends to increase REM latency and disturb normal sleep architecture. The corollary here is also true - as a rule, any drug tending to increase cholinergic neurotransmission within the brainstem, particularly the pontine reticular formation and the mesopontine tegmentum (independent of an upstream serotonergic or noradrenergic mechanism) will greatly decrease REM latency and subjectively increase both the frequency and intensity of the dream state. As for 'forcing' REM, you'd be hard-pressed to find a drug used for clinical or recreational purposes that doesn't do the exact opposite, minus (maybe) the benzodiazepines, which certainly aren't powerful enough in that regard to meet your demand. You'd be left with the limited territory of indirect cholinergics, which for these purposes fall into the broad pigeonholes of the nootropics and nerve agents, the pharmacolgic line sometimes tending to blur between the two. Anecdotal reports of the allosteric NMDA-Glycine agonist 'racetams' increasing dream vividness and frequency, coupled with some sparse literature to back it up lend support here, as does the well-documented capacity of the acetylcholinesterase inhibitors to amplify REM. Mustard agents, some pesticides, tacrine, stigmines, and their more agreeable cousins galantamine and donepezil (the latter of which I'm on at the moment) all take care of much of the same business. But outside of direct, high-ish affinity full M2 agonists, you'll be consistently underwhelmed by the comparatively 'amplifying' effects of the indirect cholinergics, something to which I can anecdotally attest on only 5mg of Aricept. The reason for this is simple - drugs that act as indirect agonists typically can only augment already-extant paracrine signaling, while full agonists are capable of stimulating a postsynaptic receptor independent of a presynaptic action potential. In other words, you're piss-out of luck with the readily available cholineric drugs, though I think there might be a way...

Going back the "monoamine-choline" hypothesis, it also follows that antagonists/inverse agonists at serotonin receptors implicated in maintaining consciousness and arousal (read: 5-HT2A) or known for depressing cholinergic activity (5-HT6) would similarly decrease latency to REM, if not 'forcing' it in higher doses - and if I remember right, they do. Mirtazapine is a well-studied culprit, as mentioned by mecaib. Melatonin is well known for boosting REM time, and from what I can pull out of my ass at the moment:


Melatonin agonists modulate 5-HT2A receptor-mediated neurotransmission: behavioral and biochemical studies in the rat.

EISON AS, FREEMAN RP, GUSS VB, MULLINS UL, WRIGHT RN.
J Pharmacol Exp Ther 1995;273(1):304-8.
CNS Developmental Pharmacology, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Wallingford, Connecticut, USA.

Abstract:


Interactions between melatonin and serotonin type 2A (5-HT2A) receptors in the regulation of the sleep-wakefulness cycle in the rat have been reported. We studied the acute effects of melatonin and related agonists on 5-HT2A neurotransmission as reflected in behavioral (head shake) and biochemical [phosphoinositide (PI) hydrolysis] responses to 5-HT2A receptor stimulation. Like 5-HT1A agonists and antidepressants, acute administration of melatonin and related agonists inhibited the 5-HT2A-mediated (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane-induced head shake in a dose-dependent manner. Consistent with these behavioral findings, in vitro incubation of cortical slices with melatonin agonists robustly inhibited 5-HT2A receptor-mediated PI hydrolysis in a noncompetitive manner. 2-Iodomelatonin-induced reductions in 5-HT2A-stimulated PI hydrolysis were blocked by preincubation with the melatonin antagonist N-acetyltryptamine. Further, pretreatment of rats in vivo with melatonin and related agonists reduced the cortical PI hydrolysis response to the 5-HT2A agonist alpha methyl-5-HT but did not alter cortical 5-HT2A receptor density. The present data support an interaction between melatonin and 5-HT2A receptors in the central nervous system.


Looks like a common mechanism. I'm guessing direct 5-HT2A drugs would be more powerful, either alone or in combination with negative modulators like melatonin, tianeptine, and such. Think ultra-low-dose risperidone, ziprasidone, asenapine, nefazodone, mianserin, trimipramine, methysergide, and friends. Mixing these and a reasonable cholinergic (huperzine, arecoline, galantamine, donepezil) would probably reduce your slow-wave sleep to a wee choad, kicking REM into something akin to an overnight dream anthology. Sorry for the lack of citations. Sleep deprived/don't have time to go science this shit. Alot of what I said is probably mostly bullshit anyway. Correct me.

mecaib
30-05-2010, 21:05
Have you taken it before? It's called remeron because it's supposed to put you to sleep. It'll knock you out. That isn't sleep. That's why insomnia is so hard to treat properly. Being knocked out is far different from sleeping, any true insomniac will tell you there is a HUGE difference.

Have I taken it? Only every night, as an AD. I always get good periods of REM sleep on it. If I miss a dose for two nights, and take it again on the third, my dreams will be even more intense than ever. Granted, I do take about 1mg melatonin per night, but even without melatonin, the mirtazapine enhances my dreams considerably. My chances of having sleep paralysis are also increased.

I would call any sleep in which I dream abundantly "good sleep," and mirtazapine helps with that. Other people I've talked to also experience better sleep with increased dream recall while on that drug, so it isn't just me.

It it possible that even though I feel like I'm getting good sleep, and am experiencing multiple dreams per night, that I'm not in fact getting good sleep?

P A
31-05-2010, 00:04
It it possible that even though I feel like I'm getting good sleep, and am experiencing multiple dreams per night, that I'm not in fact getting good sleep?

Unlikely on Remeron in particular, owing to its H1 antagonism, which accounts for it's great hypnotic properties. But yeah, there's certainly just as much potential for a fucked up sleep cycle on either side of the REM coin. More dreams/=good sleep. Although in this regard, 5-HT2A antagonists/inverse agonists specifically are known to improve sleep architecture. This makes sense, as they generally 'mimic' the 5-HT2A-deficient state of mammalian sleep. A few inverse agonists are apparently in the works to be marketed as alternative sleep aids to the benzos, antihistamines, and 'z-drugs.' Similarly for HT6:


Selective 5HT2A and 5HT6 receptor antagonists promote sleep in rats.

MORAIRTY SR, HEDLEY L, FLORES J, MARTIN R, KILDUFF TS.
Sleep 2008;31(1):34-44.
Biosciences Division, SRI International, Menlo Park, CA 94025, USA. stephen.morairty@sri.com

Abstract:


STUDY OBJECTIVES: Serotonin (5-HT) has long been implicated in the control of sleep and wakefulness. This study evaluated the hypnotic efficacy of the 5-HT6 antagonist RO4368554 (RO) and the 5-HT2A receptor antagonist MDL100907 (MDL) relative to zolpidem. DESIGN: A randomized, repeated-measures design was utilized in which Wistar rats received intraperitoneal injections of RO (1.0, 3.0, and 10 mg/kg), MDL (0.1, 1.0 and 3.0 mg/kg), zolpidem (10 mg/kg), or vehicle in the middle of the dark (active) period. Electroencephalogram, electromyogram, body temperature (Tb) and locomotor activity were analyzed for 6 hours after injection. MEASUREMENTS AND RESULTS: RO, MDL, and zolpidem all produced significant increases in sleep and decreases in waking, compared with vehicle control. All 3 doses of MDL produced more consolidated sleep, increased non-rapid eye movement sleep (NREM) sleep, and increased electroencephalographic delta power during NREM sleep. The highest dose of RO (10.0 mg/kg) produced significant increases in sleep and decreases in waking during hour 2 following dosing. These increases in sleep duration were associated with greater delta power during NREM sleep. ZO Zolpidem induced sleep with the shortest latency and significantly increased NREM sleep and delta power but also suppressed rapid eye movement sleep sleep; in contrast, neither RO nor MDL affected rapid eye movement sleep. Whereas RO did not affect Tb, both zolpidem and MDL reduced Tb relative to vehicle-injected controls. CONCLUSIONS: These results support a role for 5-HT2A receptor modulation in NREM sleep and suggest a previously unrecognized role for 5-HT6 receptors in sleep-wake regulation.

And yeah, TearItDown is half right - being sedated--->unconsciousness isn't at all an equivalent to true sleep (anesthesia, twilight, and so on). But for practical purposes, and for the large majority of garden-variety "I can't fucking fall asleep" insomniacs (me being one of them), most clinically relevant hypnotics are pretty effective at doing what they're supposed to do: they tend to put you to sleep (yes, true sleep). This however, says nothing about the quality of sleep induced by such drugs, which is often less than optimal. This doesn't appear to be a problem with mirtazapine though, and generally the opposite is the case - Remeron improves overall sleep quality, even in those without primary major depression. I took it for a full week about a year ago and gave it up due to daytime haziness, apathy, and brainfog accompanied by worsening derealization. I already go through varying degrees of all of these on a daily basis, so that just wasn't tolerable for me despite the sexy improvements in sleep quality, duration, etc. Tempted [and sleepless], I pulled the near-forgotten bottle of 15mg tabs out around the same time this year and experienced much of the same, even in smaller doses. I chalk it up to it being a histamine antagonist with a 20+hour half-life, but I'm glad it works for you mecai. At least you're not taking something obnoxious/contentious, like an SRI or MAO inhibitor. Or are you?

mecaib
31-05-2010, 02:44
- Remeron improves overall sleep quality, even in those without primary major depression. I took it for a full week about a year ago and gave it up due to daytime haziness, apathy, and brainfog accompanied by worsening derealization.

Maybe that's part of what's wrong with me lately. It's getting harder and harder to get motivated and/or interested enough to accomplish much. I chalked it up to not being able to get out of the house for exercise. Every time I miss a few day's worth of doses, though, I start getting more depressed, which might make it a bit difficult to quit.


At least you're not taking something obnoxious/contentious, like an SRI or MAO inhibitor. Or are you?

Heck no! I've been around SSRI Street, and it's an ugly neighborhood. I couldn't handle the brain zaps, or the fact that they did *nothing* for my depression. I've never been on an MAO(I).

P A
31-05-2010, 03:23
It's getting harder and harder to get motivated and/or interested enough to accomplish much. I chalked it up to not being able to get out of the house for exercise.

Though it might be only part of your 'issue'(?), I hear you with the exercise thing. I haven't been able to run in over a month - insufferable respiratory infection. Motivation is in the shitter all the more for that.



I've been around SSRI Street, and it's an ugly neighborhood. I couldn't handle the brain zaps, or the fact that they did *nothing* for my depression. I've never been on an MAO(I).

SSRIs are of dubious antidepressant efficacy to begin with, leaving me to sceptically view them as slightly beefier placebos with side effects and withdrawal syndromes, at least when it comes to vanilla MDD. Much more effective for anxiety/panic spectrum disorders. As for MAO drugs, it seems like the risks are compulsively and perpetually overstated to the exclusion of the potentially fantastic benefits for some, though almost certainly accompanied by typical reuptake blocker-ish side effects. I would never take them for the very same reason you probably won't - drug interaction, nullification, or outright fatal contraindication on the part of the very medicine I would be taking to allow me the chance to 'get on with my life,' including, but not limited to, social/personal drug use. Also have a pretty high incidence of drug-induced apathy syndromes. Oh well...

Actually, come to think of it, I'm surprised you're on mirtazapine given the mushroom in your pic (or am I inferring too much here?).

blackjesus
31-05-2010, 11:43
maybe dmt? isnt that secreted from the pineal when you hit rem? an oral dose at bed time that kicks in when you hit stage 2 or 3 of your rhythm

hugo24
31-05-2010, 15:17
He mentioned Nefazodone and the likes, I would point you towards Trazodone as its one of the few a.d.'s improving sleep architecture (Shrink also mentioned Surmontil, but its again a trycyclic with H1 antagonsim which I refused).

I tried Remeron only once and I was so fucked up the other day that I quit it and took Trazodone. It has a much reduced hangover the next day, 1 Red Bull will make you going. I've become a friend of Trazodone, unlike all other general Monoamine reuptake inhibitors, it doesen't pave you all over with effects, and down there, no losses, quite the opposite! After 4 days it had a wonderful a.d. effect (I suffered from a bad burn-out depression). And you can play with dose and altough its overall antidepressive yield is quite low, in doses north of 200-300, it shifts in a second gear with an added SSRI property.

mr shush
31-05-2010, 16:01
Gamma Amino Butrate Acid powder is good for sleep IMO

mecaib
31-05-2010, 21:43
Actually, come to think of it, I'm surprised you're on mirtazapine given the mushroom in your pic (or am I inferring too much here?).

Um, what's the problem with taking serotonergic psychedelics with mirtazapine? I know mirtazapine can dull the mushroom/acid/etc. experience. Is there something else I should be concerned about?

I have a high tolerance for such compounds anyway, and the last time I dropped acid I needed 10 hits to have a decent trip. I was on mirtazapine at the time. OTOH, DXM hits me harder than most people. I'm guessing the mirtazapine is partially to blame there too.

It's only a matter of time before somebody accuses us of going off-topic...

P A
31-05-2010, 22:12
Um, what's the problem with taking serotonergic psychedelics with mirtazapine? I know mirtazapine can dull the mushroom/acid/etc. experience.


I have a high tolerance for such compounds anyway, and the last time I dropped acid I needed 10 hits to have a decent trip. I was on mirtazapine at the time.

The 5-HT2A receptors are understood to mediate (or at least be crucially implicated in) the majority of the 'classical' psychedelics' effects. Mirtazapine blocks the 5-HT2A receptors with considerable affinity. It's really that simple. Your ingestion of a compound that directly antagonizes the primary action of a particular drug necessitated that you take inordinate amounts in compensation - that's not tolerance. More like pharmacologic cross purpose...

On the other hand, chronic treatment with 2A ligands progressively downregulates the receptor (reduces its expression on the surface of the postsynaptic neuron/negatively modifies binding affinity). This could theoretically exacerbate the situation, creating a kind of semi-irreversible tolerance that I couldn't imagine would be particularly pleasing in an average psychedelic user.


Is there something else I should be concerned about?

Nope. Nothing at all [at least not in terms of safety]. Mirtazapine is a notoriously benign drug in any number of strange combinations, if not one the safest psychotropics in current clinical use.


It's only a matter of time before somebody accuses us of going off-topic...

Lawl. I think the "topic" is pretty much over with, seeing as how OP still hasn't responded to anyone's contributions. Not to mention our little conversation takes up half the thread.

PsychedelicPeptide
02-06-2010, 06:48
Peptides such as Ipamorelin or the Growth Hormone Releasing Hormone (GHRH) analog made by conjuchem (listed as "mod GRF" on a lot of suppliers) are able to stimulate your body to release growth hormone effectively and this in turn brings more restful sleep (especially when they are taken right before sleep).

I'm not sure if they will enhance the REM sleep phase specifically, but growth hormone enhances slow wave sleep so this is enhanced.

Whether that is what you are looking for I'm not sure. I don't see a clear reason why you want REM sleep over slow wave, just better sleep in general or what the goal really is here?

-------------------------------------------------------------------------------------


Growth Horm IGF Res. 2004 Jun;14 Suppl A:S10-7.
Reciprocal interactions between the GH axis and sleep.

Van Cauter E, Latta F, Nedeltcheva A, Spiegel K, Leproult R, Vandenbril C, Weiss R, Mockel J, Legros JJ, Copinschi G.

Department of Medicine, MC 1027, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA.

Abstract

For more than 30 years, growth hormone (GH) has been observed to be preferentially secreted during deep, slow-wave sleep (SWS). However, the mechanisms that underlie this robust relationship that links anabolic processes in the body with behavioral rest and decreased cerebral metabolism remain to be elucidated. Current evidence indicates that GH secretion during the beginning of sleep appears to be primarily regulated by GH-releasing hormone (GHRH) stimulation occurring during a period of relative somatostatin withdrawal, which also is associated with elevated levels of circulating ghrelin. Apparently, two populations of GHRH neurons need to be simultaneously active to stimulate, in a coordinated fashion, SWS and pituitary GH release. Pharmacological interventions that are capable of increasing the duration and/or the intensity of SWS such as oral administration of gamma-hydroxybutyrate (GHB), also increase the rate of GH release. Because the normal negative feedback exerted by GH on central GHRH is inoperative in patients with GH deficiency, it is possible that the decreased energy levels and fatigue often reported by GH-deficient adults partly reflect an alteration in sleep-wake regulation. Preliminary data from a sleep study of adults with GH deficiency using wrist actigraphy for 6 nights at home and polysomnography in the laboratory indeed show decreased total sleep time and increased sleep fragmentation in GH-deficient patients as compared with normal controls.

rickolasnice
02-06-2010, 20:24
I know its already been said but GHB (or GBL) forcefully induces REM sleep.. ime..

Alot of phenibut does it too ;)

its.euphoric
02-06-2010, 20:44
Yeah, ghb I thought of. even tho its been said. Even if it doesn't really help induce REM, it gets you into a deeper sleep.

ebola?
02-06-2010, 23:22
k...GABAnergics tend to interfere with REM sleep (and many with stage 4). The best case with those appears leaving basal REM intact or inducing REM-rebound upon cessation. 5ht action of some sort appears to be the ticket...

but what level of REM induction counts as "forcing" REM sleep?

ebola

weekend addiction
03-06-2010, 00:05
In my experience melatonin is excellent for sleep. Especially when combined with alcohol, cannabis, kava, or just about any sedative...

i are spectre
03-06-2010, 06:20
when i take tramadol before i go to bed i have vivid dreams. i hardly ever dream because of my drug usage these days, but if i take some tramadol i actually dream...

sniffsniff
05-06-2010, 05:40
Have you taken it before? It's called remeron because it's supposed to put you to sleep. It'll knock you out. That isn't sleep. That's why insomnia is so hard to treat properly. Being knocked out is far different from sleeping, any true insomniac will tell you there is a HUGE difference.

i could back this up...i workout so i drink this energy drink called superpump250 at around 7 PM so the only time i could fall asleep is around 2-3AM. in order to get enough sleep i take stuff that knocks me out. its not the same as falling alseep on your own, i wake up in the morning feeling like shit either way :|

seep
05-06-2010, 11:09
If you do one of those special sleeping schedules where you only sleep four hours a day, every time you sleep (nap, really) you are almost instantly thrown into REM sleep. The concept behind it is that you sleep a total of four hours a day, but all of it is REM sleep.

Do you know of polysomnographic evidence that'll back this up?

Electrodes are our friends.

Esmirtazapine should be out soon.

It seems there are at least 3 orexin antagonists in mid to late stage trials now. It's not just almorexant and that GW649868 thing (both now sponsored by GSK) anymore. There's all of a sudden an MK-4305 in phase III. A lot of money going into this class. I'd like to talk to someone who's taken any of these.

Mitchy=)
06-06-2010, 00:52
@OP: Not possible with any med's as far as im aware. Unless there is something new, which i highly doubt.

Also, xanax is great to induce a temporary coma.

KingdomCome
06-06-2010, 06:19
Try GHB

ebola?
06-06-2010, 06:24
There seems to be a bizarrely high incidence of off-topic posts.


If you do one of those special sleeping schedules where you only sleep four hours a day, every time you sleep (nap, really) you are almost instantly thrown into REM sleep. The concept behind it is that you sleep a total of four hours a day, but all of it is REM sleep.

This doesn't sound right. Rather, prolonged sleep deprivation should result in rapid induction of stage 4 AND REM sleep, other stages appearing very briefly rather than nonexistently. I don't have specific data, only what I remember from a psych degree.

ebola

rickolasnice
06-06-2010, 13:08
http://www.macalester.edu/psychology/whathap/UBNRP/narcolepsy04/treat_new.html



Some scientists believe that symptoms of narcolepsy are the result of REM sleep deprivation since the REM sleep of people with narcolepsy is interrupted by frequent arousals during the night. GHB counteracts these abnormalities by increasing slow wave sleep, lessening stage 1 sleep, and reducing arousals from rapid eye movement (REM) sleep as well as increasing REM efficiency. (Scrima et al, 1990; Fry, 1987; Roth, 1988


http://www.ualberta.ca/~csps/JPPS4(2)/M.Okun/GHB.htm



A small, double-blind crossover study examined the effect of GHB in patients with narcolepsy.37 A therapeutic effect with decreased cataplexy, as well as improved nocturnal sleep quality was demonstrated.37 GHB rapidly induced sleep without suppressing REM sleep in both normal and narcoleptic patients.3

Wizzle
06-06-2010, 13:21
According to the wiki on Narcolepsy GHB increases Delta wave sleep, which is a NREM sleep type. So GHB doesn't sound right for this purpose.

In my experience GHB causes terrible sleep that makes me feel like total shit all day. I daresay I might feel better when not having slept at all. It leaves me feeling mentally and physically fatigued and also Jittery.. I have ADD though so that might influence the outcome since GHB might also have some effect on dopamine.

rickolasnice
07-06-2010, 20:59
I found the complete opposite ^

I could get a deep 4 hours sleep and wake up feeling like i'd slept nicely for 8..

Wizzle
08-06-2010, 15:35
^That seems to be really common with GHB.. I intended to mention that too but forgot about it. That's why I also theorized about ADD having some kind of effect.

It is quite clear though that GHB doesn't cause REM sleep.

Unbreakable
08-06-2010, 17:17
I am not 100% but i know damn well...
Ambiem.... Makes you ASS out so fast....i can almost put money that it will put you in REM faster

ebola?
08-06-2010, 20:39
You'd lose that bet (see what I put forth on GABAnergics and sleep cycles).
IIRC, Ambien doesn't manifest as strong an effect on sleep cycles as benzos do, but it still affects them negatively.

Jamshyd
08-06-2010, 21:06
Benzodiazepine withdrawal is a sure way to induce lots of REM sleep because, as ebola points out, they block REM. That said, I do not think that getting addicted to benzos then suffering withdrawals just to have vivid dreams is a sound plan.

Nicotine Patches give me very vivid dreams. I rarely ever dream, or remember my dreams for that matter. Not sure if this has to do with REM or not.

Jamshyd
08-06-2010, 21:09
Btw, I don't know where all that GHB crap is coming from. I barely remember sleeping on GHB, let alone any dreams I may have had.

And GHB is a horrendously addictive substance, not really a good idea just for a nice dream or two.

/navarone/
09-06-2010, 02:06
How about an MT1 MT2 and MT3 agonist like Ramelteon (http://en.wikipedia.org/wiki/Ramelteon)?

infaroot
09-06-2010, 02:20
there are products that people use for lifting so they get more rest because its supposed to help recovery by putting u in a deeper sleep. Look at ZMA its a certain zinc magnesium thing thats supposed to increase testosterone and it does make u drowsy and have very vivid dreams. I take "Bullet Proof" by muscle pharms and it has ZMA along with other things that are supposed to help. It definately works because i will take it on a empty stomach and like 30 min later ill be really tired and ready to fall asleep and i have crazy dreams. When i wake up i feel real refreshed and no problems getting up.

rolls_
29-10-2011, 20:41
Bump for an interesting thread.

Has there been any developments in the pharmaceutical world that might help with getting better quality sleep?

specialspack
29-10-2011, 21:46
Esmirtazapine should be out soon.

It seems there are at least 3 orexin antagonists in mid to late stage trials now. It's not just almorexant and that GW649868 thing (both now sponsored by GSK) anymore. There's all of a sudden an MK-4305 in phase III. A lot of money going into this class. I'd like to talk to someone who's taken any of these.

Almorexant was abandoned due to its side effect profile, according to the wiki - which sucks for GSK as they paid $147 million for it... I wonder what made it unsuitable?

fly-
29-10-2011, 23:04
Alcohol increases REM sleeping in low-doses.

http://en.wikipedia.org/wiki/Alcohol_use_and_sleep

rakketakke
30-10-2011, 22:31
Xyrem (Prescription GHB) is used for narcolepsy with cataplexy. It helps by giving the patient fuller sleep. Not sure if this is actually increasing REM sleep. Anyone know a bit more about this?

GHB is wonderful along with the dopamine rebound it makes the perfect sleeping aid (for me)

Sure GHB is addictive if you are going to redose every 4 hours for a week straight, then the physical addiction kicks in.

Small dose before sleep? No problem, still an endogenous substance...

Torabora
30-10-2011, 23:04
what is with histamine antagonists? My GF takes Seroquel and likes the sleeping on it very much as the dreams are very clear (okay Seroquel is not only a Antihistamine but its the effect which makes you very tired even at low doses) or other antihistamines like Diphenhydramine or Doxylamine

FlippingTop
31-10-2011, 01:00
How about an MT1 MT2 and MT3 agonist like Ramelteon (http://en.wikipedia.org/wiki/Ramelteon)?

fascinating stuff. Although:


Ramelteon caused hyperprolactinaemia two to three times more often than placebo in clinical trials. Studies of rats and mice showed a dose-dependent increase in cancer. The long-term safety in humans is unknown. Ramelteon was teratogenic in rats.

nuvanob
31-10-2011, 01:28
Well, I'm not sure how relevant this is to your question but low dose LSD might do the trick. Check out the REM chart here: http://countyourculture.com/2010/10/21/alterations-in-the-nocturnal-sleep-cycle-resulting-from-lsd/

While the initial REM episodes a half hour or so after waking are similar, after 30ug of LSD the second REM episode occurs much earlier and lasts almost three and a half times longer than the corresponding REM episode after placebo. Many more micro-REM episodes lasting only ten to twelve seconds burst into sleep for several hours after the LSD has taken effect.

In general, LSD can prolong the first or second REM episode and cause these REM micro-bursts, but only if given in low doses immediately before sleep or one hour after sleep begins. Doses that are too high simply cause the sleeper to awaken as they are about to transition to REM sleep.

Joseph N. Muzio, Howard P. Roffwarg, Edward Kaufman, Alterations in the nocturnal sleep cycle resulting from LSD, Electroencephalography and Clinical Neurophysiology, Volume 21, Issue 4, October 1966, Pages 313-324.

Nagelfar
31-10-2011, 08:57
When I think of drugs and REM, I think of the opposite of sleep or sedatives (though I know in this case it would be one function); drug-types known for lowering seizure threshold, evoking unconscious but non-sleep REM fits. i.e. seizures.

tmdoca
31-10-2011, 17:50
What about 5-hydroxytryptophan? supposed to increase duration of rem sleep. Id imagine that would go well with melatonin. http://www.sciencedirect.com/science/article/pii/0013469471901477

PS 50th post