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View Full Version : New hydromorphone ER - Exalgo



BIGsherm7272
29-01-2010, 09:24
Looks like we may soon enough have continuous-release Hydromorphone back in the states sometime soon:

http://www.drugs.com/nda/exalgo_090923.html

I do not know exactly how the OROS, which is an oral osmotic delivery system, exactly works. But still looks promising.

woamotive
29-01-2010, 15:31
Nice. I'd love to have some of that.

bigpoppax23
13-03-2010, 07:54
Exalgo was approved on March 1st 2010 by the FDA. The extended release they employ for the matrix of Exalgo is very interesting... hopefully it will work out better than Palladone. Still waiting for other opiates to be approved... Chronogesic, Instanyl, and Nasalfent.

http://www.combinatorx.com/products_pain_exalgo.php

~BIG~

Kurrupt
13-03-2010, 17:54
I'm confused why Purdue hasn't made HydromorphContin available in the states, it's extended release Hydromorphone HCL and comes in 3,6,12,16,14,30mg sizes we have it here in Canada :\. Palladone was taken off the market because alcohol would defeat the time release and FDA thought warnings weren't enough right?

Violenza666
13-03-2010, 20:21
I am very interested in this medication. I can't wait!

dokomo
13-03-2010, 23:25
Exalgo was approved on March 1st 2010 by the FDA. The extended release they employ for the matrix of Exalgo is very interesting... hopefully it will work out better than Palladone. Still waiting for other opiates to be approved... Chronogesic, Instanyl, and Nasalfent.

http://www.combinatorx.com/products_pain_exalgo.php

~BIG~

If I'm not mistaken, that system is also the one used for Concerta brand extended-release methylphenidate

bigpoppax23
14-03-2010, 04:18
I'm confused why Purdue hasn't made HydromorphContin available in the states, it's extended release Hydromorphone HCL and comes in 3,6,12,16,14,30mg sizes we have it here in Canada :\. Palladone was taken off the market because alcohol would defeat the time release and FDA thought warnings weren't enough right?

Yes, people would drink even the smallest amount of alcohol and it would totally defeat the extended/time release system... releasing all of the Palladone which dosed all the way up to a 32mg Hydromorphone ER...
So your HydromorphContin can take that!;)
But seriously... it would ovbiously be AWESOME if HydromorphContin was available in the USA... but the FDA do whatever they please. With that being said the Exalgo will be FINE. The extended/time release in Exalgo will only be defeated by crushing it and taking it intranasally... dont know about injecting it... I would say NOT being able to inject it based on the polymers in this Osmotic extended/time release system. YEAH! you heard me... FUCKING POLYMERS... YAY!


If I'm not mistaken, that system is also the one used for Concerta brand extended-release methylphenidate

Yes, many medications use a similar or exact Osmotic extended/time release system.
http://www.pharmainfo.net/reviews/review-latest-advancement-patented-controlled-sustained-release-drug-delivery-system
It is the OROS PUSH-PULL system.

~BIG~

morphinanymous
25-04-2010, 15:15
8o why the fuck would anyone want hydromorphone er. Every ER pill made sucks. ER Opanas blow, so I thkn ER Hydromorphones would suck as well. You can't boot Opana ER's if you say you do then more power to you, but I don't believe you, its like people who snort or try to get off on MS Contin. I dated the daughter of a very high up at working on MS CONTIN. ER pills. He literally had samples and bottles of tens of thousands legally and legitally I wouldn't even bother taking them. I have would rather be sick than take an ER pill or put the energy into telling myself I was high after I snorted/shot something that didn't work. Have fun wasting you're money. The only way these would be worth a damn is if the Extended Release was easily, and safely removed, which just like with the TimerX or w/e in Opana will suck and end up causing more arms to fall off than fill up.

Sorry I hate ER's. :!

TheDankaholic
22-05-2010, 16:27
Well as you guys know I'm sure I've been RX'd Dillies for a loooooong time now. I'm currently taking 120 8mg's Instant Release Dillies a month & now just last week my Dr. decided he wants me to also try this "new" drugs as he put it and wrote me an RX for 120 8mg Dillies as usual plus 60 12 mg Exalgo ER tablets. After closer look I realized they were these extended release Hydromorphone tablets. SO I guess my new dose is 24mg Instant release with 24 mg's extended release a day.

We all know I'm not shy with the spike, I may not IV as much as before but you best bet I'll be back real soon with a report on how easy or hard these are for the IV'ers out there. We all know a dillie isn't worth being called a dillie If you can't bang it. If these are just a harder way to get the same thing Iw ould out of 1 1/2 of my 8's (which are CRAZY easy to fix up. Probably easiest pill to ever bang) than they won't be worth much to me. It's almost re-fill day so full report from me coming soon.

K'd-OUT-in-AZ
27-05-2010, 10:34
I'll be back real soon with a report on how easy or hard these are for the IV'ers out there. We all know a dillie isn't worth being called a dillie If you can't bang it. If these are just a harder way to get the same thing Iw ould out of 1 1/2 of my 8's (which are CRAZY easy to fix up. Probably easiest pill to ever bang) than they won't be worth much to me. It's almost re-fill day so full report from me coming soon.

It should be near impossible to IV them due to the polymers in this Osmotic extended/time release system. So I believe if you want to come back with your report it will be more on the hard to not-be-able-to side.

1cupofwater
31-05-2011, 10:06
ok the exalgos. all of em. 8,16 so on.
first get the cating off completly. you will notice one side is gray and one side is white and has a pin hole. you need to geth the grey sid off the white sid completly. seperate them with a pair of vice grips, plyer, whatever. split it. you will have excess grey matter on the white. you need to get a file or seraded knife and shave that off. this took some practice and was not simple. now. theese things wont crush for shit. so you have to shave or file them down. you can have some chucks in there. but the more and bigger chunks the longer it takes to disolve. ok,. here latley this thing with the pills is that you dont add heat. heat gels them. i use and i knowwwwwwwwwwwwwwww this sounds crazy. water with ice cubes in it. ice damn cold water. the colder the better. put the shavings into you resivoir. (i suggest a bigger one than spoon sinse lots of water should be needed. add about 4 cc ice cold water and just keep stirring and knocking it around, crushing on it with your finger mayber or anther object. you will begin to see it dissolve,. and eventually it will all dissolve. you will still have the casing in there. it may take a good while. and some practice. but im telling you when you get the reward. its actually pretty good. now iver never tried heating theese as heat will draw the hydromoraphone into the was. i actually havnt noticed much residue left back or was so heat may be a good idea here. im out. so somone try that and let us know.

1cupofwater
31-05-2011, 10:09
i meant wax. sorry. heat draws hydromoraphone into wax. like i said. i have ived them. yes preperation takes some time. but it was a powerful rush.

leftwing
31-05-2011, 11:43
If I'm not mistaken, that system is also the one used for Concerta brand extended-release methylphenidate

indeedian it is

docbp87
31-05-2011, 17:57
8o why the fuck would anyone want hydromorphone er. Every ER pill made sucks.

I know where you are coming from... but you gotta remember, these tablets were designed as an analgesic, not a recreational drug. In fact, they have aspects in them specifically to discourage misuse.

hydroazuanacaine
31-05-2011, 18:23
this seems like a thread and discussion that members are interested in, but it is not a BDD question.

OD, it's yours.



BDD---> OD

Fire&Water
08-06-2011, 22:36
ok the exalgos. all of em. 8,16 so on.
first get the cating off completly. you will notice one side is gray and one side is white and has a pin hole. you need to geth the grey sid off the white sid completly. seperate them with a pair of vice grips, plyer, whatever. split it. you will have excess grey matter on the white. you need to get a file or seraded knife and shave that off. this took some practice and was not simple. now. theese things wont crush for shit. so you have to shave or file them down. you can have some chucks in there. but the more and bigger chunks the longer it takes to disolve. ok,. here latley this thing with the pills is that you dont add heat. heat gels them. i use and i knowwwwwwwwwwwwwwww this sounds crazy. water with ice cubes in it. ice damn cold water. the colder the better. put the shavings into you resivoir. (i suggest a bigger one than spoon sinse lots of water should be needed. add about 4 cc ice cold water and just keep stirring and knocking it around, crushing on it with your finger mayber or anther object. you will begin to see it dissolve,. and eventually it will all dissolve. you will still have the casing in there. it may take a good while. and some practice. but im telling you when you get the reward. its actually pretty good. now iver never tried heating theese as heat will draw the hydromoraphone into the was. i actually havnt noticed much residue left back or was so heat may be a good idea here. im out. so somone try that and let us know.
The ice water meathod works great for dissolving, after smashing w/ a morter&pestal I cut into tiny shreads w/ a razor (I swirled 32 mgs. around in a shotglass, put in freezer for a few minutes, took out swirled again for 5 minutes)
Took about half an hour total...my question, the half oz. or so of water is a little
"slimy" from whatever the binder is that makes it (plastic-like) I dont IV and was wondering if it is safe for anybody to, would cotton or filter prevent the "slimy" part from being in the pull ? Im going to drink the liquid & report back if anybody is interested...

Fire&Water
08-06-2011, 23:06
The ice water meathod works great for dissolving, after smashing w/ a morter&pestal I cut into tiny shreads w/ a razor (I swirled 32 mgs. around in a shotglass, put in freezer for a few minutes, took out swirled again for 5 minutes)
Took about half an hour total...my question, the half oz. or so of water is a little
"slimy" from whatever the binder is that makes it (plastic-like) I dont IV and was wondering if it is safe for anybody to, would cotton or filter prevent the "slimy" part from being in the pull ? Im going to drink the liquid & report back if anybody is interested...

I just realized (while drinking) the binder doesnt dissolve - It bound itself into a small thin floater, chewed it up to be sure...mmmm crunchy Will report more...
I know my tolerance is gonna shoot fast w/ these, (like any good opiate/opiode) I'm mainly going to use the Exalgo to cut down on the withdrawls Im gonna start experiencing quitting 60 mgs. of daily methadone...Its a purty' shiddy drug for pain -hopefully I will end up liking the Exalgo taking them the (proper) way...

DaveTripper
09-06-2011, 04:11
8o why the fuck would anyone want hydromorphone er. Every ER pill made sucks. ER Opanas blow, so I thkn ER Hydromorphones would suck as well. You can't boot Opana ER's if you say you do then more power to you, but I don't believe you, its like people who snort or try to get off on MS Contin. I dated the daughter of a very high up at working on MS CONTIN. ER pills. He literally had samples and bottles of tens of thousands legally and legitally I wouldn't even bother taking them. I have would rather be sick than take an ER pill or put the energy into telling myself I was high after I snorted/shot something that didn't work. Have fun wasting you're money. The only way these would be worth a damn is if the Extended Release was easily, and safely removed, which just like with the TimerX or w/e in Opana will suck and end up causing more arms to fall off than fill up.

Sorry I hate ER's. :!

Idk if I'm mistaken, but aren't the yellow 40mg Opanas extended release? If so, I blew a shit ton of those, and while they do gel up, if you take it slow and do small lines it most certainly gets you off, at least it did for me. If they aren't ER, then my bad. ;)

lmc422
09-06-2011, 18:22
If you go into the hydromorphone thread there's a post on how to break the exalts down for iv use. I've done it myself and it works.
Here's how to do it.
-wash/rub the coating off. You will see half is white and half is gray.
- cut the pill down the center of the white and grey.
- throw out the grey part(there's no drug in it)
-scrape off any gray left on the white half.
- you will notice there's a thin clear coating around the white part. Carefully shave/peel it off
- crush the white part in a mortar and pestle as fine as possible
- put crushed hydromorphone into spoon
- add very very cold water
- filter and enjoy!!!

***I've done this many times and it works great!! Amazing rush. I had the 32mg ones I think. I only did half of the powder and got a super good rush and high. This method is also in the hydromorphone mega thread.

Hope this helps anyone who has these that's trying to beat the oros system for snorting or iv'ing. Again I've done this method quite a few times. I'm not one to say something works if it clearly doesn't. Good luck!

Fire&Water
09-06-2011, 19:57
If you go into the hydromorphone thread there's a post on how to break the exalts down for iv use. I've done it myself and it works.
Here's how to do it.
-wash/rub the coating off. You will see half is white and half is gray.
- cut the pill down the center of the white and grey.
- throw out the grey part(there's no drug in it)
-scrape off any gray left on the white half.
- you will notice there's a thin clear coating around the white part. Carefully shave/peel it off
- crush the white part in a mortar and pestle as fine as possible
- put crushed hydromorphone into spoon
- add very very cold water
- filter and enjoy!!!

***I've done this many times and it works great!! Amazing rush. I had the 32mg ones I think. I only did half of the powder and got a super good rush and high. This method is also in the hydromorphone mega thread.

Hope this helps anyone who has these that's trying to beat the oros system for snorting or iv'ing. Again I've done this method quite a few times. I'm not one to say something works if it clearly doesn't. Good luck!

I dont know if they made 32mg. when they were new on the market last year...
I do know that the only available now are 8 12 & 16 mg tabs'

Elalgooj
04-09-2011, 03:36
The future is here your post says 9-6-2011. Its 9-3-11 in southern Va. I think 16mg is the largest now.

Fire&Water
04-09-2011, 03:57
The future is here your post says 9-6-2011. Its 9-3-11 in southern Va. I think 16mg is the largest now.

The (day) is the first number...I know, different huh ? The # 6 is June.

Elalgooj
05-09-2011, 23:59
Thanks must have had a buzz.

gatman
19-09-2011, 21:14
I was getting these for 1yr 2x20ml and 3x5ml a day the 20mil would gell up in your nose. And you would get a big ball of gell coming down you had to mush it with your toungh. The 5mil you can snort or shoot do what ever you wont with it same with the 10mil if its round and blue its a 5 if its round and red its a 10IRs the 8sided ones are ERs. Anyways it got to where thay where only lasting me 10days I told dr. to keep them and went back on meth 80mil. and it works for pain thats what it was for in the 1st place....%)

gatman
19-09-2011, 21:16
opana

Superduper88
21-09-2011, 09:48
I have a few 16mg Exalgos. I've taken off the outer shell and separated the greyish substance from the white part(which to my knowledge is pure hydromorphone?). I don't want to IV could I just crush the white part up dialogs it in water and drink it? Or even cut it in 2 and take that?

And I also wanted to see how the dosage is on these since it's extended release 24hr. Is it safe to take all of that at once? I take Lortabs very frequently 3 at a time 10 mg. Some help por favor!

emptyob
31-10-2011, 21:34
Hello there one cup...this is my firsts time ever writing to this sort of site...although these things have long been a keen interest to me...but anyway, you seem to be very knowledgeable about these things, so I was hoping you might find the tie to answer a quick question...I just was prescribed 90 12 mg exalgos and although it took quite an effort to find a pharmacy that carried them, I did eventually find one. But the question is this: is it possible to take them with a view to getting a really good buzz?are these things worth anything on the ?street

asscapper
02-05-2012, 21:01
I have a few 16mg Exalgos. I've taken off the outer shell and separated the greyish substance from the white part(which to my knowledge is pure hydromorphone?). I don't want to IV could I just crush the white part up dialogs it in water and drink it? Or even cut it in 2 and take that?

And I also wanted to see how the dosage is on these since it's extended release 24hr. Is it safe to take all of that at once? I take Lortabs very frequently 3 at a time 10 mg. Some help por favor!

i also have the 16mg Exalgos priscribed by my doctor and would like to know if i could just snort them after doing this method and how much, i could take 50 mil oxicodone oral or 20 mil opana snorted,please does anybody have any experience?thanx in advance.

Kid Amine
02-05-2012, 23:20
i also have the 16mg Exalgos priscribed by my doctor and would like to know if i could just snort them after doing this method and how much, i could take 50 mil oxicodone oral or 20 mil opana snorted,please does anybody have any experience?thanx in advance.

Exalgo doesnt crush worth shit tho it is water soluble, so I guess you could use it as a nasal spray. I wouldnt, because Exalgo dries ROCK HARD once the water evaporates. It would be pretty much like putting Super Glue up your nose. Eat em, plug em or bang em, but no way up the nose on these things. If you want to do that use IR hydromorphone pills or something else entirely.

asscapper
02-05-2012, 23:54
Exalgo doesnt crush worth shit tho it is water soluble, so I guess you could use it as a nasal spray. I wouldnt, because Exalgo dries ROCK HARD once the water evaporates. It would be pretty much like putting Super Glue up your nose. Eat em, plug em or bang em, but no way up the nose on these things. If you want to do that use IR hydromorphone pills or something else entirely.

thank you for your advice.

asscapper
04-05-2012, 01:57
if i could take 50 mil oxicodone oral or 20 mil opana snorted can anybody please tell me how much of the cruched 16mg exalgo can i eat safely?

Fire&Water
04-05-2012, 02:12
if i could take 50 mil oxicodone oral or 20 mil opana snorted can anybody please tell me how much of the cruched 16mg exalgo can i eat safely?

Dissolve in 3-4 ml of water in freezer, warm it back up then plug.

asscapper
04-05-2012, 03:23
Dissolve in 3-4 ml of water in freezer, warm it back up then plug.

sorry for asking but i'm a little worried about ODing so did you mean all the 16mg's of the exalgo?

Fire&Water
05-05-2012, 05:01
sorry for asking but i'm a little worried about ODing so did you mean all the 16mg's of the exalgo?

If you hose 20 mg's of opana ???

asscapper
05-05-2012, 08:48
If you hose 20 mg's of opana ???

do you mean snort when you say"hose"?sorry for my ignorance.and like i said i could eat like 50mg or 60mg of oxicodone or snort 20mg of opana ER.

Fire&Water
06-05-2012, 00:59
Think about it (read up on the meds you are using)... if you are capable of snorting 20 mgs of opana, 16 mgs of exalgo is going to be weak (orally) now if you dont have a problem w/ plugging its possible to achieve some pretty heavy affects (depending on how often you snort opana)...

asscapper
07-05-2012, 23:28
Think about it (read up on the meds you are using)... if you are capable of snorting 20 mgs of opana, 16 mgs of exalgo is going to be weak (orally) now if you dont have a problem w/ plugging its possible to achieve some pretty heavy affects (depending on how often you snort opana)...

i allways take 30mg of morphine ER and 20mg of oxycodone every 6 hours and only 2 times a week i eat 45 or 50mg of oxycodone recreational,i haven't snorted opana for a while now so maybe it doesn't matter.

trieditalll
04-09-2012, 10:18
Well i just tried the cold water method with exalgo 8mg and they suck i mean there is a little rush but id rather set a rubber opana on fire any day lol i know that sounds crazy but they are actually pretty damn awsome

exlago12
05-03-2014, 03:45
Got switched to exlago 12mg...know how to break everything down to just the hydromorphone and dont IV at all! Has anyone came up w a way to snort these? Also what is everyones best way of taking these to get the best high you can?

LoveNOpes
08-03-2014, 20:24
Just want to confirm that the cold water is the trick! Love you bluelighters. Excited to have just joined the community!

Snorting is a different story, though:
1. Suck off white coating
2. Cut straight down the middle, trash the grey part.
3. Cut white bit in half
4. Carefully peel the plastic off.
5. Chop up white into pieces & use straw to shotgun.
6. You will have to shove bits back up nose, but it stays on the membrane which actually helps with the high.
7. Be ready to nod out all over America.

I've only had the 32s and they not an f'ing joke lol

Be careful, friends. xo

sarajenni88
28-03-2014, 20:22
O
Just want to confirm that the cold water is the trick! Love you bluelighters. Excited to have just joined the community!

Snorting is a different story, though:
1. Suck off white coating
2. Cut straight down the middle, trash the grey part.
3. Cut white bit in half
4. Carefully peel the plastic off.
5. Chop up white into pieces & use straw to shotgun.
6. You will have to shove bits back up nose, but it stays on the membrane which actually helps with the high.
7. Be ready to nod out all over America.

I've only had the 32s and they not an f'ing joke lol

Be careful, friends. xo

I have the 32 too. I usually plug...this really works? Wow ty

Screaming_Skull
29-03-2014, 06:31
Ohh Exaglo, the first thing I ever Iv'ed. Remember we would just cut it into small pieces and let it dissolve in cold water, also plugged it and it was very nice... it's been 2 years soo its kinda hazy... was good plugged at 12mg, this was when I was clean for about a year then broke that with of all things IV Diludaid when my tolerance was, well I didn't have one... wish I didn't do that looking back, my life has been kinda fucked stuck in the same place ever since. But wish I had some of those fuckers now!!