PDA

View Full Version : nicotine and alprazolam



drylightning
24-05-2009, 01:20
Hi,

I take alprazolam for panic disorder and I also chew tobacco (stupid, I know). I've read that cigarette smoking can reduce the effects of alprazolam. Is this due to the nicotine, or something in the cigarette smoke? In other words, does chewing tobacco also affect the strength of alprazolam?

Thanks in advance for the info...

Dan

ro0ga
24-05-2009, 02:31
smokeless tobacco shouldn't effect the metabolism of the alprazolam, the additive effect of the nicotine agonization and the benzo together might give you a nicer buzz. cigarettes are different though, the hydrocarbons from the cigarette smoke (not the nicotine!) induce the cytochrome enzymes 1A2 and 3A4, the latter being responsible for the breakdown of the alprazolam. inducing 3A4 will decrease the effect of the alprazolam and give you a lesser benzo buzz.

hope this was helpful.

Oh ROXIanne!
24-05-2009, 05:22
smokeless tobacco shouldn't effect the metabolism of the alprazolam, the additive effect of the nicotine agonization and the benzo together might give you a nicer buzz. cigarettes are different though, the hydrocarbons from the cigarette smoke (not the nicotine!) induce the cytochrome enzymes 1A2 and 3A4, the latter being responsible for the breakdown of the alprazolam. inducing 3A4 will decrease the effect of the alprazolam and give you a lesser benzo buzz.

hope this was helpful.

Does this apply to valium as well...and does it affect the speed of the metabolism of the drug or does it just lessen the effects?

drylightning
24-05-2009, 06:36
smokeless tobacco shouldn't effect the metabolism of the alprazolam, the additive effect of the nicotine agonization and the benzo together might give you a nicer buzz. cigarettes are different though, the hydrocarbons from the cigarette smoke (not the nicotine!) induce the cytochrome enzymes 1A2 and 3A4, the latter being responsible for the breakdown of the alprazolam. inducing 3A4 will decrease the effect of the alprazolam and give you a lesser benzo buzz.

hope this was helpful.

Very helpful - thanks!

Captain.Heroin
24-05-2009, 07:12
It's definitely better to not smoke cigarettes on xanax.

TheMatador
24-05-2009, 20:24
Does this apply to valium as well...?

Indeed, it applies to most benzodiazepines as they are metabolized by the same cytochrome enzymes.

Fuzati
25-05-2009, 13:54
How much weaker nicotine makes xanax feel?

I'm a daily tobacco smoker and I'm on xanax everyday for anxiety... I tried to quite smoking to get the full effetc from my alprazolam, but when I don't have my nicotine dose I'm getting anxious, so it's not really helpfull...

So does anybody have any idea on how bad tobacco makes xanax less potent? If it's something like -10%, it's fine, but if it's much more I would rather considering quitting smoking for good. =/

monstanoodle
25-05-2009, 21:06
It doesn't make it less potent, but it will increase clearance. So in essence it won't last as long.

brutus
25-05-2009, 21:55
I've never noticed a difference when I smoked while on Xanax and when I did not.

subisjustokay
26-05-2009, 17:12
I also use smokeless tobacco and Alprazolam, nightly, and I have never noticed the combo having a negative effect...

Still works GREAT for me...

Fuzati
26-05-2009, 19:25
Me neither... Well I always take my morning xanax (I usually take 2mg on the morning, and 0.5 at night) with a large glass of white grapefruit juice, to make it last longer... So maybe the juice and the tobacco concel each other, and at the end I just have the normal effects from my alprazolam. :)

pinpoint
26-05-2009, 19:33
thank god, I thought this was going to be another thread about smoking pills.

ro0ga
24-07-2009, 05:57
How much weaker nicotine makes xanax feel?

I'm a daily tobacco smoker and I'm on xanax everyday for anxiety... I tried to quite smoking to get the full effetc from my alprazolam, but when I don't have my nicotine dose I'm getting anxious, so it's not really helpfull...

So does anybody have any idea on how bad tobacco makes xanax less potent? If it's something like -10%, it's fine, but if it's much more I would rather considering quitting smoking for good. =/


in theory the interaction exists, but honestly i don't think the interaction is very significant...if you're smoking 1+ packs a day, it may be more noticeable, but a few cigarettes here and there i don't think will make a huge difference.

PinK~cloud
03-08-2009, 09:55
So i've always thought that after i smoke, or if i smoke before taking xanax, the effects are weaker. i've always avoided smoking if i'm going to do it, for that reason.

today, i was at the pharm' filling up my suboxone when i picked up a pharmasuitical book. i was flipping through the book and stopped at alprazolam.
inside the "Drug Interactions" section it read,

"Smokers may need higher doses of Alprazolam because smoking may reduce up to 50% of Alprazolam in the blood steam."

I've read other threads before of people complaining about this also. everyone always said it's placebo because they work on different parts of the brain.

Must this be true>?

Captain.Heroin
03-08-2009, 09:59
It is true.

If you're worried about getting the most out of your alprazolam, switch to chewing tobacco when you're on alprazolam. It's not an effect of the nicotine but an effect from a by-product of the tobacco smoke itself (hydrocarbons? someone posted an explanation around here that was much more detailed - I will see if I can find it).


http://www.ncbi.nlm.nih.gov/pubmed/9098872?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

Nonlinear mixed effects modeling of single dose and multiple dose data for an immediate release (IR) and a controlled release (CR) dosage form of alprazolam.
Hossain M, Wright E, Baweja R, Ludden T, Miller R.

Office of Clinical Pharmacology and Biopharmaceutics, Center for Drug Evaluation and Research, FDA, Rockville, Maryland 20857, USA.

PURPOSE: NONMEM was applied to single dose and multiple dose bioavailability data for an immediate release (IR) and a controlled release (CR) dosage form of alprazolam to acquire additional information from the data which are not easily obtainable by traditional means. METHODS: The objective function value (OBJ) and diagnostic plots were used as measures of goodness of fit of the model to the data. A change in the OBJ value of 7.9 was necessary to show statistical significance (p < 0.005) between two models when the two models differed by 1 parameter. RESULTS: A two-compartment linear model with first-order absorption and elimination best describes the data. Including a lag time, two different rates of absorption (KAIR and KACR), and bioavailability for the CR relative to the IR dosage form significantly improved the fit of the model to the data. Cigarette smoking was associated with a 100% increase in clearance of alprazolam as compared to non-smokers. The higher residual variability observed in this study, where interoccasion variability (IOV) was not initially modeled, could be explained to a large extent by the presence of significant interoccasion variability (IOV). CONCLUSIONS: Since alprazolam has been suggested to be mainly metabolized by the CYP3A4 isozyme in humans, it appears that tobacco could be an inducer of CYP3A4 and/or alprazolam may be metabolized by other isozyme(s) (specifically, CYP1A1/1A2) that are induced by cigarette smoke. The population pharmacokinetic model approach combined with exploratory graphical data analysis is capable of identifying important covariates from well-controlled "data rich" Phase I studies early in drug development.


http://www.ncbi.nlm.nih.gov/pubmed/11524025?ordinalpos=12&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

Smoking in patients receiving psychotropic medications: a pharmacokinetic perspective.
Desai HD, Seabolt J, Jann MW.

Department of Pharmacy Practice and Pharmaceutical Sciences, Mercer University, Southern School of Pharmacy, Atlanta, Georgia 30341-4155, USA.

Many psychiatric patients smoke, and are believed to be heavier smokers than those without psychiatric disorders. Cigarette smoking is one of the environmental factors that contributes to interindividual variations in response to an administered drug. Polycyclic aromatic hydrocarbons (PAHs) present in cigarette smoke induce hepatic aryl hydrocarbon hydroxylases, thereby increasing metabolic clearance of drugs that are substrates for these enzymes. PAHs have been shown to induce 3 hepatic cytochrome P450 (CYP) isozymes, primarily CYP1A1, 1A2 and 2E1. Drug therapy can also be affected pharmacodynamically by nicotine. The most common effect of smoking on drug disposition in humans is an increase in biotransformation rate, consistent with induction of drug-metabolising enzymes. Induction of hepatic enzymes has been shown to increase the metabolism and to decrease the plasma concentrations of imipramine, clomipramine, fluvoxamine and trazodone. The effect of smoking on the plasma concentrations of amitriptyline and nortriptyline is variable. Amfebutamone (bupropion) does not appear to be affected by cigarette smoking. Smoking is associated with increased clearance of tiotixene, fluphenazine, haloperidol and olanzapine. Plasma concentrations of chlorpromazine and clozapine are reduced by cigarette smoking. Clinically, reduced drowsiness in smokers receiving chlorpromazine, and benzodiazepines, compared with nonsmokers has been reported. Increased clearance of the benzodiazepines alprazolam, lorazepam, oxazepam, diazepam and demethyl-diazepam is found in cigarette smokers, whereas chlordiazepoxide does not appear to be affected by smoking. Carbamazepine appears to be minimally affected by cigarette smoke, perhaps because hepatic enzymes are already stimulated by its own autoinductive properties. Cigarette smoking can affect the pharmacokinetic and pharmacodynamic properties of many psychotropic drugs. Clinicians should consider smoking as an important factor in the disposition of these drugs.


The above quotes were taken from: http://www.bluelight.ru/vb/showthread.php?t=446477

PinK~cloud
03-08-2009, 10:04
that is so interesting. i had no idea. i read another post about this a while back but no one ever pulled that out.

Captain.Heroin
03-08-2009, 10:08
that is so interesting. i had no idea. i read another post about this a while back but no one ever pulled that out.

I don't smoke cigarettes at all so I don't have any personal experience IMO.

I would advise quitting tobacco if at all possible.

PinK~cloud
03-08-2009, 10:30
^
i wish it were that easy :(

Captain.Heroin
03-08-2009, 10:44
^
i wish it were that easy :(

Have you tried Zyban (bupropion) or Chantix?

CretiNation
04-08-2009, 04:22
aha, the Captain beat me to it! to contribute at least slightly to this thread, subjectively, i definitely felt the alprazolam-cigarette interaction before i was aware of the research. i just didn't make the connection because smoking tobacco always made me jittery to an extent.

oh and yeah this is off-topic but congrats and bravo on the modship, Cap'n! i haven't been 'round here in a bit but it's definitely long overdue, there are very few in OD more deserving or just outright perfect for the position.

ok, enough ass-kissing i need a smoke ;)

PinK~cloud
04-08-2009, 05:22
Have you tried Zyban (bupropion) or Chantix?
i've tried bupropion in the past but not for nicotine help. it made me feel a little too stimulated so i got off of it. and i've heard of chantix and i may give it a try after i get off the suboxone. unfortunately both are expensive medications.

acid_staind
04-08-2009, 18:39
cigarettes are different though, the hydrocarbons from the cigarette smoke (not the nicotine!) induce the cytochrome enzymes 1A2 and 3A4, the latter being responsible for the breakdown of the alprazolam. inducing 3A4 will decrease the effect of the alprazolam and give you a lesser benzo buzz.



this is true but when i'm benzo'ed out its my favorite time to smoke cigarettes. never noticed any reduction in length or decrease in buzz.

it just feels so good to smoke when you can barely move lol.:p
but i smoke like a chimney on most drugs especially opiates, coke and def acid.

prsnmalam
21-08-2009, 09:44
does this affect ALL benzoes or just those said above?the breaking down of IV midazolam?

Colmes
21-08-2009, 11:57
I think any effect that nicotine would have on the effectiveness of a relaitvely powerful benzo (alprazolam)- would, in my opinion (having done it, repedidly) would be minimal. If you are not feeling xanax like you once did its due to ..........toldeance, not the nicotine. Tolerance builds in 2 weeks and is much more noticeable than any nicotine effect on the benzo.

Captain.Heroin
22-08-2009, 03:28
I think any effect that nicotine would have on the effectiveness of a relaitvely powerful benzo (alprazolam)- would, in my opinion (having done it, repedidly) would be minimal. If you are not feeling xanax like you once did its due to ..........toldeance, not the nicotine. Tolerance builds in 2 weeks and is much more noticeable than any nicotine effect on the benzo.

It's not the nicotine which speeds up the metabolization - it is a byproduct of tobacco smoke which causes this.

toastedpanda
22-08-2009, 04:25
^What about cannabis smoke, would it reduce effects as well?

Captain.Heroin
22-08-2009, 04:47
^What about cannabis smoke, would it reduce effects as well?

Nope. I'm pretty sure not.

yoyoman
25-09-2010, 00:58
Funny thing happened! I took some xanax earlier today, along with some methamphetamine.

Anyway i'm just blabing around on the internet, and i use chewing tobacco and haven't used any today, so i started chewing some (potent kind).

As the buzz came on, its like the xanax almost totally went away.. so i googled "xanax nicotine" and the first hit on google was this thread.. its like the nicotine (or something else in the tobacco) is kicking the alprazolam off some receptors temperarily... everything got really clear, and the meth really kicked in hard.

F1n1shed
25-09-2010, 01:25
Well the only time i smoke cigarettes are when im fucked up as well which means benzo's and i have never noticed a difference. In fact i really enjoy the buzz of nicotine and xanax together, i have tried xanax by itself as well. I really don't think it kills much of the xanax off, maybe a tad. But for those of you that are scripted xanax daily, you should probably not smoke on it as you have a tolerance to benzo's and wouldn't want it to kill off your medication.

SkagKush
25-09-2010, 02:15
ya thats wack, i never knew that, i used to smoke on alpraz and i never got the effects i expected.

j.zhivago
25-09-2010, 02:31
I don't smoke cigarettes at all so I don't have any personal experience IMO.

I would advise quitting tobacco if at all possible.

There is a big difference between tobacco and cigarettes.There is NOTHING wrong with pure,unaltered,organically grown tobacco.The nicotine myth has got to stop!!!!!
Our brains have nicotine receptors.The cancers which are caused by the tar are from the herbicides,pesticides and hundreds of additives that are PURPOSEFULLY put in cigarettes to harm humans.Nicotine is active ONLY in the BRAIN.This is why we see the cancers in the throat,stomach,mouth and lungs where the tars leach into.
Indigenous peoples in South America have been using tobacco for thousands of years in its native environment and there is virtually no recorded cases of cancers and the species they use has up to 2 or 3 times the nicotine levels we westerners and europeans use.To them,tobacco is 'medicine'.
I normally don't get too upset at all but I cant stand this constant harmful nicotine/tobacco propaganda.The division has to stop now!!!

revned04
27-09-2010, 23:08
Sorry to dig up this old thread, but I quit smoking and am using nicorette ( nicotine gum) for the time being just to help with the urges. Would that also decrease alprazolam effectiveness? I love taking xanax occasionally with my suboxone but I hadn't smoked a cig in afew days, just nicorette, then took a bar and smoked one and the xanax felt alot less strong. I don't know if thats just for now or what. I love my xanax but luckily have been able to keep the usage down to a minimum, by just taking what my sub doc gives me. Long story short I took a bar 3 days ago so I would expect that tolerance is lowered by now, so would it be the cigarette that makes me feel less faded? It was also taken on an empty stomach so food wasnt what made it weak.

SkagKush
27-09-2010, 23:18
it is def a possibility... happened to me with benzos the other day........

robbraun1985
15-02-2012, 21:08
Hey ...i have been doing alot of research on this topic.....i have called numerous pharmacys and even my doctors office...and i also called phizer to see if chewing tobacco also has an effect on metbolism.....and you know what they all said..........they are not sure.....so my question to yall is how long should you wait after your last smoke or chew to take a xanax???

Thomas29
29-02-2012, 05:19
Hey ...i have been doing alot of research on this topic.....i have called numerous pharmacys and even my doctors office...and i also called phizer to see if chewing tobacco also has an effect on metbolism.....and you know what they all said..........they are not sure.....so my question to yall is how long should you wait after your last smoke or chew to take a xanax???

I was wondering the exact same thing.... Someone must know or be able to get a vague idea. All it would take is a bit of trial and error experimenting or w/e you want to call it lol.

obscure
29-02-2012, 09:45
Something that may or may not be relevant here but, sometimes when I smoke I get anxiety/panic attacks. I'll pop a xanax and then feel fine. There is, at least for me, some definite relation between what these two substances do.

I also chew tobacco and that never triggers the attacks, only smoking(usually after a number of cigarettes.)

this may say more about my individual chemistry, but there is something to this argument one way or another.

S.M.F.G
29-02-2012, 13:39
Ive a healthy tollerence to xanax and have smoked throught the whole time on it (one month off ciggys now) Its tricky coz thers definitly something there, but it never seemed to have decreased effects back when my tollerence was low, Ive gone onto an E-cig to try and combat this + avoid all the nastys of smoking, Its hard to tell the difference these days, but i gotta say that I bielieve the ciggys effected me but only after a year or so and built tollerence. Go fuigure.
Interested in the vape method with the E-cigs weather or not theres any chems in them cartriges that may be fucking with my xanax...(am perscribed this just to note n dont well actualy cant abuse it).

laCster
29-02-2012, 14:36
smokeless tobacco shouldn't effect the metabolism of the alprazolam, the additive effect of the nicotine agonization and the benzo together might give you a nicer buzz. cigarettes are different though, the hydrocarbons from the cigarette smoke (not the nicotine!) induce the cytochrome enzymes 1A2 and 3A4, the latter being responsible for the breakdown of the alprazolam. inducing 3A4 will decrease the effect of the alprazolam and give you a lesser benzo buzz.

hope this was helpful.

i agree and i can definitely tell from first hand experience that it does decrease the effects. (placebo?)

but how come i don't notice any lesser effect with opiates like oxy? oxy is metabolized through 3A4, but i feel like the ciggs make the high better...

Thomas29
09-02-2013, 00:51
Does Tobacco Reduce the Effects of Temazepam?

Captain.Heroin
09-02-2013, 00:58
Does Tobacco Reduce the Effects of Temazepam?

In general, tobacco does reduce the effects of benzodiazepines. I'm sure it applies just as well to temazepam. I don't use nicotine or tobacco whatsoever, so I don't have any personal experience to share.

synthetix
09-02-2013, 01:05
From lots of use with benzos while being a smoker and while I'd quit - I know that if I haven't smoked within two weeks of taking a benzo they definitely affect me harder. If I smoke they are very noticeably weaker. If I have a cigarette while under the influence of benzos (but most notably Xanax) it really kills the sedative properties but retains its antolyxic effects. I do need to take a higher dose of benzos to feel them unfortunately as I am a cigarette smoker, however, there is mixed literature on the subject and apparently some benzos are affected more than others, while some claim they all are. In my experience all are apart from flunitrazepam which coincidentally and strangely was potentiated by smoking cigarettes.

Thomas29
09-02-2013, 02:41
Well Grapefruit does no Potentiate Temazepam so do the Hydrocarbons from Tobacco smoke still effect it?

Captain.Heroin
09-02-2013, 03:50
There is a big difference between tobacco and cigarettes.There is NOTHING wrong with pure,unaltered,organically grown tobacco.The nicotine myth has got to stop!!!!!
Our brains have nicotine receptors.The cancers which are caused by the tar are from the herbicides,pesticides and hundreds of additives that are PURPOSEFULLY put in cigarettes to harm humans.Nicotine is active ONLY in the BRAIN.This is why we see the cancers in the throat,stomach,mouth and lungs where the tars leach into.
Indigenous peoples in South America have been using tobacco for thousands of years in its native environment and there is virtually no recorded cases of cancers and the species they use has up to 2 or 3 times the nicotine levels we westerners and europeans use.To them,tobacco is 'medicine'.
I normally don't get too upset at all but I cant stand this constant harmful nicotine/tobacco propaganda.The division has to stop now!!!

Nicotine inhibits your body from producing testosterone/estrogen in both men and women, it's far from a benign substance. You can also overdose on nicotine.

I don't think nicotine is a substance anyone should have to use.