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View Full Version : How does one maximize opiate obsorbtion?



mikebobjohn
26-02-2009, 15:29
If one had access to oxycodone, hydrocodone, and morphine, how could one maximize obsorbtion of those medications when taking them orally?

For morphine, is it best to take it on an emtpy stomach, full stomach? Right after a meal? Right before? Does taking it with any certain type of food or drink increase its effects?

And the same questions for both oxy and norco. Empty stomach, full? Before/after meal? What foods or drinks to take it with?

And finally, I'm looking for any simple, safe, legal ways to potentiate these drugs as well. I looked in the opiate potentiation thread and the suggestions were almost all random drugs I hadn't heard of and thus didn't know whether or not they were safe. Many required prescriptions that most can't get ahold of. I'm just looking for simple stuff one could buy at the pharmacy or the grocery store that will make opiates taken orally either have a stronger effect and-or make the opiates last longer.

If there is no simple or moderately simple solution, then I am interested in hearing the top best (and completely safe) more complicated solutions. The other problem I had with the opiate potentiation thread was there loads and loads of various ideas of supposed ways to potentiate opiates, so I had no idea which ones to actually pursue because there were so many. So I'm just interested in the simplest, safest, and most effective. I'm not looking just to get more tired like with benedryl, or anything like that. I'm looking for something that actually increases the opiate warmth, buzz, relaxation, euphoria, and pain relief (or as many of those as possible), and-or makes the opiate's effects last longer than they normally would.

Thank you very very kindly for your help. It is quite needed and very very much appreciated indeed.

hexxx
26-02-2009, 15:57
For oxymorphone (Opana), a fatty meal is recommended to increase bio availability. I'm not sure if this has any effects on other opiates.

Binge Artist
26-02-2009, 16:55
Take the drugs after a fairly intense weight training session. Absolute heaven.

phunkojunk
26-02-2009, 16:58
I agree with the first reply. Fatty meal, preferably lots of starches. Why not steak and taters? WHY NOT?!

phunkojunk
26-02-2009, 16:59
oh yeah, id say... RIGHT before a meal works best for me

JerseyJunkie
26-02-2009, 17:03
smoke cigs after you take it

parliamentes
26-02-2009, 18:47
tagamet is a good potentiator for hydro and oc (don't know about morphine though). In my opinion, it doesn't make the drugs 'hit' harder, but it increases the duration significantly. Take ~600mgs an hour prior to your your regular oc/hydro dose.

personally i prefer to do all drug sessions on an empty stomach or slightly-filled stomach (never full basically). i also never eat in the middle of a session. it's probably all mindset, but i don't feel as if i can get any more fucked up if i eat a little bit. i haven't really read anyone else feeling the same, so this might just be unique to me (or a small few).

and of course, you have to smoke some cigarettes after your dose. always, always, ALWAYS makes me feel even more fucked up. cigarettes are what put me over the edge (in a good way) or what brings me to that wonderful 'nod' state.

Lady Codone
26-02-2009, 19:03
I've heard that Tagamet, quinine (in certain brands of tonic water), and antihistamines all potentiate or at least STRENGTHEN the opiate high. Have also heard good things about grapefruit juice, though I don't know the science behind any of these.

Of course, having a low dose of a benzo like Xanax or Valium, some good weed, or a sensible amount of alcohol can also add to the "nod" effect, but aren't potentiators per se. The emptier your stomach is, the harder most opiates will hit, but this can increase stomach upset for some people.

headcase666
27-02-2009, 02:50
Empty stomach, and drink a hot mug of tea. Hits you within 10 minutes.

Shovelist
27-02-2009, 02:57
I like eating something very small.. wait 20 min since my metabolism is working hard... then break the pill (depending on what it is) and eat it.

Hits me very fast and hard.

jackie jones
27-02-2009, 03:00
Take with food.

SupDUDES
27-02-2009, 03:11
If one had access to oxycodone, hydrocodone, and morphine, how could one maximize obsorbtion of those medications when taking them orally?

For morphine, is it best to take it on an emtpy stomach, full stomach? Right after a meal? Right before? Does taking it with any certain type of food or drink increase its effects?

And the same questions for both oxy and norco. Empty stomach, full? Before/after meal? What foods or drinks to take it with?

And finally, I'm looking for any simple, safe, legal ways to potentiate these drugs as well. I looked in the opiate potentiation thread and the suggestions were almost all random drugs I hadn't heard of and thus didn't know whether or not they were safe. Many required prescriptions that most can't get ahold of. I'm just looking for simple stuff one could buy at the pharmacy or the grocery store that will make opiates taken orally either have a stronger effect and-or make the opiates last longer.

If there is no simple or moderately simple solution, then I am interested in hearing the top best (and completely safe) more complicated solutions. The other problem I had with the opiate potentiation thread was there loads and loads of various ideas of supposed ways to potentiate opiates, so I had no idea which ones to actually pursue because there were so many. So I'm just interested in the simplest, safest, and most effective. I'm not looking just to get more tired like with benedryl, or anything like that. I'm looking for something that actually increases the opiate warmth, buzz, relaxation, euphoria, and pain relief (or as many of those as possible), and-or makes the opiate's effects last longer than they normally would.

Thank you very very kindly for your help. It is quite needed and very very much appreciated indeed.

For morphine, the best way is not to take it orally, as 10% of it is metabolised I believe. But if you want to go the non-dirty route and take it orally, I believe eating a cheese sandwich and taking some Tums will somewhat improve it's absorption, if little.

Oxycodone and hydrocodone have both got great bioavailabilities when taken orally.

Proglumide has potentiating effects of opioids if taken 30 minutes to 1 hour prior to opioid consumption. If you have no access or can't import proglumide, then I'd just take some Tagamet, about 400-800 mg of the drug 30 minutes prior to opioid consumption.

Benadryl (dipenhydramine) will somewhat potentiate the effects of oral oxycodone, morphine and hydrocodone, and will relieve you of the itch and some nausea associated with such drug use. You may also look into getting a prescription for Hydroxyzine if you live in the USA, or some OTC products like Doxylamine succinate and Promethazine.

It's no problem dude, just remember that people do die from taking opioids, and die quicker from combining drugs. If you really must look for methods to potentiate your high, then I'd recommend you rather take a break from opioid use and reduce your tolerance because it says a problem is lurking beneath the surface when you are looking for non-natural ways to potentiate/strengthen your high from drugs.

Peace.

saveyour
27-02-2009, 03:23
absorption

Shovelist
27-02-2009, 03:47
Just got food and will take a little more to absorb with the food. :)

InTherapy82
27-02-2009, 05:06
did u ever try snorting the meds?
the bio availability is higher and so is the onset of action for most meds so u'll be getting more outta the pill
there is info about how to snort/insufflate each pill here on BL
also rectal has higher bio availability than oral for a lot of meds

the BA of each ROA is different depending which med u are taking about
here is a link:
http://www.drugs-forum.com/forum/showthread.php?t=22807

leila762
27-02-2009, 12:51
Ime, taking on an empty stomach with plenty of hot liquid potentiates oral opioids greatly.
A lot of users swear by tagamet antacids & other stomach pills.

I would add that i would have also crunched the pills i have taken , sustained release & instant release.
I visit quite a few sites concerned with oral opiods eg,oxy,mst, dhc continus etc & all of them caution that 'crunching' the sustained release versions in some instances have caused a fatal 'rush' that could be similar to a cardiac arrest.
In the spirit of harm reduction, i always try to stay as well informed as possible about anything i might be taking or might be thinking of taking.

take care

ranunky
27-02-2009, 16:23
A lot of users swear by tagamet antacids & other stomach pills.



It's nothing to do with the fact that tagamet is a stomach pill. Tagamet just happens to inhibit an enzyme involved in clearing a lot of opiates from the body. So although tagamet works, there is no reason to presume that other stomach pills will do the same. I know that you are only saying what other people believe but I just wanted to clear that up for anyone reading who might be confused.

mikebobjohn
01-03-2009, 23:26
Thanks for your help everyone!

So are tagamet and quinine completely safe to take? Isn't quinine a maleria medicine? Doesn't sound too safe. And are they both over the counter?

Grapefruit juice would obviously be the easiest if it really worked. Does it?

Also, to the person who said hot tea. What kind of tea specifically? Or does it matter?

Some have said take with lots of food, some have said take with none. Which is correct?

Also, I notice that when I'm really tired, or half asleep, or going to bed and falling asleep, or when I wake up in the middle of the night and take medicine and then go back to sleep... in all of those instances, just basically when I'm exhausted, I notice that opiates affect me like twice as strong as they usually do. As in there is more warmth, more relaxation, more "euphoria." What is it about being tired that potentiates opiates? There must be a scientific explanation. It must be that one of the chemicals the body makes or releases more of when tired potentiates opiates. So is it melonin? Which is it? Which chemical is the one that potentiates opiates when one is tired? Anyone know?

And if anyone has any more ideas please add them.

Again, thank you all so much for replying. I really appreciate the time it takes to share your wisdom.

pallidamors
01-03-2009, 23:58
^Tagamet is safe to take, and its over the counter, maybe you can find some generic cimetidine since Tagamet (the brand) gets pricey. IIRC, large doses of quinine aren't great for you, as in if you took several malaria pills. However quinine is also in tonic water, and as long as you just have a glass of it or something you'd be fine.

Personally though I feel like being tired doesn't really potentiate opiates. Instead it just alters the content of my experience, and makes it crappier.

Bob Loblaw
02-03-2009, 06:22
There's a rather large thread about opiate/opioid potentiation around.

>ENLiGHT*
02-03-2009, 07:11
also rectal has higher bio availability than oral for a lot of meds
that^^ and also morphine lasts much longer after a good fatty meal (steak, chicken, e.t.c) when taken orally. A few back, a simple 10mg of sulphate had me for 6+ hours, of course I have NO opiate tolerance at all so that played a large factor.
Oh and I hear this grapefruit juice talk but cant confirm.

Unknown
02-03-2009, 09:13
Any oral medication will onset quicker, as well as utilizing more of the drug on an empty stomach.I would take it on a empty stomach, wait 10-20 minutes later, then pig out!

Cane2theLeft
02-03-2009, 12:23
^I would wait more than 10 minutes... probably about 45. If you are eating something you really enjoy and its pleasurable, it will combine with the peak of the opiate and increase the euphoria... anything like this that works on your dopamine pathways is going to increase the euphoria. This may have very little effect for some or very pronounced for others. When I had less opiate tolerance and I would eat something really good when my meds first kicked in I'd get this nice little temporary euphoria and sometimes even nod out a bit- something that NEVER happens in my usual use of opiates.

mikebobjohn
13-03-2009, 14:54
Thanks everyone for replying. Can someone please confirm or not dismiss the idea of taking grapefruit with opiates? Also, does tea actually combine with opiates to make them stronger? Or is it just that tea is warm or something?

Also, how could one increase the amount of hydrocodone metabolized into hydromorphone? and what about the amount of oxycodone metabolized into morphine?

thanks

medusacascade
13-03-2009, 15:42
Cimetidine has been mentioned here. I used to be prescribed that, but got a stomach ulcer anyway (long story) what I want to know is, will Lanzoprazole have the same effect? I'm currently prescribed 240mg of DHC, 5mg Valium, 60mg Baclofen, Celecoxib, 150mg Imipramine, and the Lanzoprazole, but keep forgetting to take the Lanzoprazole, plus 10mg tablets of Sevredol to use if I have severe pain. I don't seem to be getting a buzz off any of it. Am I doing something wrong, or am I one of those people who seem to 'block' the formation of Dihydromorphine from DHC in the brain? I don't know if you have the same names for meds in the US?

Colmes
13-03-2009, 15:51
I'd say...cleverly wrap said opiate in more opiates. I think that would increase something.

oh ya, also some like benzos, or antihistamines, or grapefruit juice(select) to potentiate

Colmes
13-03-2009, 15:54
Cimetidine has been mentioned here. I used to be prescribed that, but got a stomach ulcer anyway (long story) what I want to know is, will Lanzoprazole have the same effect? I'm currently prescribed 240mg of DHC, 5mg Valium, 60mg Baclofen, Celecoxib, 150mg Imipramine, and the Lanzoprazole, but keep forgetting to take the Lanzoprazole, plus 10mg tablets of Sevredol to use if I have severe pain. I don't seem to be getting a buzz off any of it. Am I doing something wrong, or am I one of those people who seem to 'block' the formation of Dihydromorphine from DHC in the brain? I don't know if you have the same names for meds in the US?

Someone asked how to poteniate opiates;
I know a good deal of pharms, but i dont know how much info youll get on Lanzoprazole, severdol, celecoxib ect... ask a Doctor, they have white coats sometimes, and an office.

Or you could just ask us about your medication regimine...lol

ranunky
20-03-2009, 21:56
Thanks everyone for replying. Can someone please confirm or not dismiss the idea of taking grapefruit with opiates? Also, does tea actually combine with opiates to make them stronger? Or is it just that tea is warm or something?

Also, how could one increase the amount of hydrocodone metabolized into hydromorphone? and what about the amount of oxycodone metabolized into morphine?

thanks

Grapefruit juice inhibits the same enzyme as Tagamet. You want white grapefruit juice.

I don't think there's an easy way of doing either of the other things you ask. The enzyme that does hydroc -> hydrom is CP450 2D6. You want inducers of that enzyme, those include rifampicin (very common antibacterial), dexamethasone (you may have some of theis if someone you know was treated for glucocorticid imbalance) and others. http://en.wikipedia.org/wiki/CYP2D6 Oxycodone -> morphine is more than one step, plus oxymorphone is much more potent than morphine so you'd want to induce the oxyc -> oxym conversion. This is done by the same enzyme, cytochrome P540 2D6.

PottedMeat
20-03-2009, 23:57
I am a strong believer in taking about 8 ounces of grapefruit juice prior to chewing up the med and wash it down with another cup of juice.
I have always been told that the juice temporarily reduces the acidity level in your stomach. This allows for more of the drug to be absorbed in the stomach instead of the strong acid in your stomach breaking down some of the active ingredient.

I can definitely feel a big difference vs taking the med with any other liquid.

wwindexx
21-03-2009, 02:13
I've heard grapefruit juice. It doesn't increase absorption but it's a potentiator, and I think that's what you're looking for (more bang for your buck).

Benzorider
14-04-2009, 19:49
When you have morphine in any pill form, crush it up, add 3-4 ml water and then plug with oral syringe... best choice hands down if you dont wanna IV... about 55-60% uptake (it feels like compared to IV).

Hey i just slammed 60 mg of IR morphine hcl up my butt and 1 hour after i feel great :D

Captain.Heroin
14-04-2009, 20:30
smoke cigs after you take it

Gross. That's not going to really get you any higher, either.

Medic11
15-04-2009, 17:36
yes, grapefruit juice (white is the best and never from concentrate) does work for potentiation except for codeine in which case you will dramatically inhibit its effects.

Quercetin and a number of other flavenoids in grapefruit juice are inhibitors of CYP2D6 and CYP3A enzymes that catabolize opiates during first pass metabolism.

Anything that inhibits these enzymes will potentiate i.e. Cat's Claw, Goldenseal, Tagamet, Quercetin etc etc etc

There is a good megathread on potentiation...you should check it out.

KrisTheGreat
15-04-2009, 17:42
i have noticed that if i take them on an empty stomach i get real high but for a short amount of time then i feel sick and hungry. the best way for me is to wait exzactly an hour after my last bite of food. when i was on hydros real bad this was a rule i lived by. Even though the more and more i think about it maybe it was the start of OCD?!?!?!?!

brutus
15-04-2009, 18:25
Eat pills on a completely empty stomach and make sure to crush them before taking the pills.

sleeplessdwarf34
15-04-2009, 20:36
I guess my question falls along these lines. I don't need the high to be "higher" just longer. Due to my doc, my opiate of choice is percs(10) Ofc in the beginning I could pop 30 mg and jam out for 3-4 hours. Now I pop 50 mg to get the same initial hit but it last way shorter. I have tried grapefruit juice, but that was also the first time I ever plugged the percs. So I have no real way to know. I have started taking a phenergan with each dose. I know this does more for the high, as the nurse told me so, but that was combined in an iv so not sure if it works as well just chewing it. So, is potentiating the same as trying to extend the length or is there another way to make that happen? A 1 hour buzz for 5 percs SUX.

jstb0b
21-04-2009, 03:40
Medic11 - "grapefruit juice (white is the best and never from concentrate)"

That explains alot. I tried some white grapefruit juice (from concentrate) and I didn't notice a damn thing. Thanks for clearing that up for me.

bunnycat007
22-11-2010, 15:34
Well I am not a doctor or chemist, but I can tell you from personal experience, that grapefruit juice is a good way to enhance some drugs, but not all and that is key. Like, it will definitely work for valium, even says so as a warning on my bottle label, and it seems to do the same thing with a few other drugs, like Soma, but I really cannot say that it helps potentiate any other drugs any better, and as far as Tagamet--yes, but only on certain drugs, not all. Like I was totally surprised by what happened one day when I had severe indigestion, and I took a tagamet, and about an hour later, had just received some Soma and took my usual 4 or 5 and man, was I sorry I had taken that many THAT day. I was falling over the place, stumbling, and eventually passed out for about 3 or 4 hours. AND that had never happened before with only 4 or 5 Somas. That many is usually just a TEASER for me, if I really [/COLOR]want to get wasted on Soma, it takes way more than that, but that day, it had to be the tagamet I had taken about an hour before.

Someone in here said something about smoking. As a smoker myself, for over 30 years, I cannot honestly say that it enhanced my reaction to pain meds, but it sure did increase my craving for a cigarette so badly that I could hardly wait to get outside so I could light one up. It is common knowledge amongst the medical field that smoking and using BENZOS, WILL definitely DECREASE the effects of certain benzos, but not enhance the effects at all. Maybe that works differently for pain meds but not for benzos.

I just use the old grapefruit and tagamet tricks for all controlled drugs I get, just to see what happens, nothing really all that dramatic has happened, except with the Soma that day I had taken tagamet.

therealSparky
12-11-2017, 06:13
Wjen I run low on my oxy contin , I take one of the small bottle of tonic water , about 4 or 6 oz , and fill my glass up with ruby red grapefruit about an hour or two before pill time , empty stomach other than the drink , then instead of the 12 hour pill I just take half the amt of my oxycodone breakthrough pill and it knocks the hell out of the pain , fuzzy feeling lips , nodding , and so on.. also if you smoke , don't smoke for 2 or 3 days , and only smoke after the fuzzy tingling teeth and nose and eye brow itch start.. and it will make you definatey sit down.. but be very carefull , I have been on these for over 10 years now after a multilevel neck fusion from a few discs extruding , long lasting nerve damage, so I have a hell of a tolerance , wjen doing the tonoc and grapefruit juice 20 to 30 mg of fast release knocks me weenie to the side , where without grapefruit and tonic it takes about 200 mg to get in that state of buzzedness

ColoradoBoy90
12-11-2017, 13:54
FATTY MEALS HAVE INSANE OPIATE/OPIOD BOOSTING AFFECTS.
I discovered this by accident. I took oxycodone like normal, and my normal dose. Then I ate a sausage biscuit, and suddenly I got hit HARD. I was like whoa, wtf, why did me eating make me feel it 2-3X more??
Then I googled it and saw basically ALL opiates/opioids are heavily boosted (they claim 30% peak plasma level boost, but I think it's much higher)
Then a few times I noticed that if I took an oxy/hydro with no food I wouldn't feel it, and would go through WD!! One time I didn't have food with me, so I took another. I was still in minor WD. So at 2x my normal dose it still hadn't fully worked.

Then later in the day I took the same dose, this time with a small fatty meal/snack. It instantly knocked out WD with 1 pill and felt normal...

In fact if I don't eat I go through WD, EVERY SINGLE TIME. I know because I do it often **hoping** I can train my body to make it work, it doesn't. My body has become used to that 30% ++ plasma level increased. If I don't get it, I go through WD... so now I have to eat, constantly!