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View Full Version : Captodiamine - mechanism of action?



wungchow
04-10-2008, 18:58
http://upload.wikimedia.org/wikipedia/commons/thumb/8/88/Captodiame.svg/220px-Captodiame.svg.png

After doing a little research I found that this molecule lacks antihistaminergic effects, and is an effective anxiolytic at doses of 150mg, also lacks the sedative effects of benzodiazepines.

Any ideas as to what receptors it targets?

Jamshyd
04-10-2008, 20:01
I'm guessing it is "anxiolytic" the same way Hydroxyzine is "anxiolytic". I believe there is an old captodiamine thread in this forum already. Do a search.

Riemann Zeta
04-10-2008, 20:17
It certainly looks like it would have antihistaminergic and antimuscarinic effects. If it looks, smells like, walks like, talks like...an antihistamine, it probably is.

kaskelot
04-10-2008, 21:44
Diphenhydramine inhibits reuptake of serotonin, is it probable that this substance does as well?

Except for this article, http://www.medscape.com/viewarticle/489359 , I have not been able to find any digitalised material on captodiame/captodiamine. According to a title (this one, http://www.ncbi.nlm.nih.gov/pubmed/13572247?ordinalpos=10&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum ) captodiamine potentiates hexobarbitol, perhaps someone has access to it?

Hammilton
06-10-2008, 02:25
I was almost positive I started a thread on this under my old account, but I don't see it now. the other bl maybe?

nuke
06-10-2008, 03:34
It has a structure similar to modafinil too. Weird.

MurphyClox
06-10-2008, 18:32
Oh yeah, the structural similarity to modafinil is indeed astonishing.

Captodiamine is known to potentiate the action of barbiturates, thiobarbiturates, ketobemidone, pethidine, isomethadone, and morphine, most probably by inhibition of metabolising enzymes (CYP-family).

To my best knowledge, the exact molecular pharmacology (targeted receptor(s)) is not known, as captodiamine was abandoned some time ago and oviously nobody sees the need for new investigations.

Murphy