View Full Version : Phenibut Tramadol interaction

24-05-2008, 14:15
Is there any interaction between Tramadol and Phenibut?

I have a feeling Phenibut (4-amino-3-phenyl-butanoic acid) antagonizes tramadol ((±)cis-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl) cyclohexanol hydrochloride), but not its M1 (O-Desmethyltramadol) metobolite (3-[2-(1-Amino-1-methylethyl)-1-hydroxycyclohexyl]phenol)?

Because of the structural similarity to PEA, phenibut may share some similarities and differences with it. When phenibut is administered along with PEA, it antagonizes many of its effects, such as promotion of anxiety, promotion of seizures, and hyperthermia. This has lead some to postulate that antagonism of PEA, rather than the GABA-mimetic activity, may be the important mechanism of action for tha anxiolytic effect of phenibut. Phenibut also increases dopamine levels, and it has been postulated that the structural similarity to PEA may play a role in this effect.

Please feel free to comment.

29-05-2008, 02:21
I reworded the question above to hopefully make more sense.