Being very experienced with Opana, I think I can help out here a bit. I'm going to break it down into ER and IR, and then ROA of each.
Opana ER (10,20,40mg)
- Intranasally, I actually prefer these to the IR pills. The high doesn't peak until about 15 minutes after insufflation, but it lasts a good 3-4 hours. Yes, it does gel up, but it doesn't gel up the same way that MS-Contin or Teva OC's do. Instead, the gelling up seems to help with the insufflation by extending the high over a much longer period of time. A good starting dose for an opiate-naive person would be 2.5-5mg. Anymore and there is a good chance of vomiting.
- Intravenously, well, there it can't be done, unfortunately. Some people have tried using Isopropyl alcohol, but I tried and it didn't work for me. I'm glad it didn't, because think about how bad that could be?
- Rectally, the ER works pretty well also, similar in strength to insufflation, but with a slightly longer duration, and a slightly different feel. Onset is about 30 minutes, and duration about 5-6 hours if you "evacuated" yourself well prior to using this method. It's also not a bad idea to do an enema 20 minutes or so before using the drug. Dosage is similar to insufflation.
- Orally, it's about as good as OxyContin that is twice the mg dosage, i.e. 10mg Opana ER is around the same as 20mg OxyContin. This is concerning analgesia and pain relief, not euphoria or recreational effects, which I did not try to achieve via this ROA with Opana or OxyContin (with the latter's time release intact). Starting dose is much safer to gauge orally; I'd say take what you can do orally in oxycodone IR and divide it by four.
Opana IR (5,10mg)
- Intranasally, it hits quicker than the ER, but it doesn't last as long. I would say it peaks within 3-5 minutes and lasts 2-3 hours. It doesn't burn at all, but it does have that distinct "I'm snorting a pill" feel to it: chalky and rough. Make sure to grind it up really well. With the IR, starting dose should be 2-4mg.
- Intravenous, this is where this drug really shines. The rush is much stronger than Dilaudid (which was my favorite before I discovered Opana), and depending on how much you do it can have a stimulating effect like oxycodone or it can make you nod HARD. The way I do it is foolproof, and has always worked for me. I use one full 10mg tablet, cut it up with a sharp knife, and then smash and grind with a plastic ID card. Then, I put the powder in a spoon and add 100units of H2O. I stir really well, making sure that no solid pieces remain. Once this is done, I take a lighter and gently heat the bottom of the spoon for about 10 seconds. You do NOT want the water to boil, just become warm. This helps the drug dissolve into the water better somehow. Stir again, and then let sit and absorb into the water for as long as you can be patient for (usually 5-10 minutes for me). Then, use your cotton, suck up until the cotton becomes clogged, and put the drawn solution in a second spoon. You'll have to use a couple cottons to get everything out of the first spoon, but it's worth the work. Then, you'll want to add new (more) water to the original spoon that has pink goop in it because you most likely only got about 8 of the 10mg out the first time. Use about 80units for the second run, but stir it in and let it sit for a while longer this time. While you're doing that, filter the original solution again, and then backload it into your injection syringe. You probably have about 85-90units of solution, so tap out the bubbles, stick in vein, register, and push. Now, feel the full-body orgasm commence. A good starting dose is 1-2mg (2mg MAX) for a new user. My friend who is mildly opiate tolerant IV'd 2.5 and threw up a couple times.
- Never used the IR rectally.
- Never used the IR orally.