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Deep Kick
08-01-2008, 02:24
How much do you think certain drugs potentiate opiates?

For example i will list the drugs i use to potentiate opioids (and which opioids) and what percentage of the opioids high i feel (in my experiences) is increased (if at all) by the potentiator.

~20-65%.....cannabis (depending on quality & quantity it can boost the high over 60% especially depending on the strain)

~15-35%.....benzos (in order from best to worst: valium, ativan, xanax, klonopin, librium) i enjoy mixing as many as possible w/ opiates.

~10-40%.....other opiates (not sure if it's considered "potentiating" but the high is boosted for sure, morphine + codeine in PPT is a great combo)

~10-25%.....diphenhydramine (i've only tried up to 25mg)

~5-15%.......hydroxyzine (another antihistamine, i dosed with ~30mg, and it was similar to DPH,)

~5-10%.......alcohol (not sure if i'd consider it a potentiator... but it makes me more buzzed but so does mixing coke + opiates...)

~5-8%.........grapefruit juice (8 oz consumed 60-90 minutes prior dose gives slight boost in effect and duration, but nothing great)

~3-6%.........gabapentin (could be mental, but does work the first time you take it)

~2-10%.......marinol (10-20mg can increase the high, taken 1-2 hrs prior dosing)

~2-5%.........naproxen sodium (aleve, 220-500mg definitely adds a nice subtle warmth)

~1-4%.........cyclobenzaprine (flexeril is a TCA anti-d. muscle relaxant that provides a slight boost)

~1-2%.........loperamide (could easily be a placebo effect)


drugs i'd like to try for potentiation: carisoprodol, DXM, doxylamine, promethazine, barbiturates, and tagamet.


peace

mukant666
08-01-2008, 02:47
I dont think benzos boost the opiate high. For me benzos make the opiate's euphoria more subtle but it does make me more sedated.

I agree that cannabis is the strongest potentiator for opiates... I love opiate+cannabis combo :)

Aeon Psyche
08-01-2008, 02:50
Naproxen ??

Hmm. I've use dph, barbs, benzos & alcohol. The latter sucked in combination with opiates. All the other seemed nice. I can't tell from my experience an estimate of how much percent it boasted the effects.

OxyMorph
08-01-2008, 02:57
I believe that benzo's are the best when it comes to the synergy of the high. I have always liked the roxi+xanax combo. It seems that whenever i smoke weed after i have done some oxycodone the weed high TOTALLY overtakes the nice opiate high! So i never seem to smoke weed when i'm on the opes!

phrozen
08-01-2008, 03:29
Damn n00bs not using the word "potentiator" correctly. :p

racerriderj
08-01-2008, 03:31
+1 on not adding the benzo's. They dull the opiate high.

Benzo's have their uses, save them for when you need them.

To each his/her own =)

Psychlone Jack
08-01-2008, 04:24
I'm not going to throw any exact figure out there cause there's no reall way to judge it accurately IMO, but about an hour ago I took 30mg hydrocodone and 50mg diph... I'm surprised how high I am off that little amount.

johanneschimpo
08-01-2008, 04:49
I used to laugh so hard back in high school when people said smoking a cigarette after getting stoned increased your high 33.3%
Yes, they said "33.3%"



phrozen: "how much do you think certain drugs synergize with opioids?"

sixpartseven
08-01-2008, 05:01
^ Im sure I speak for him too when I say that is a much better way to say it.

I heard that weed thing too, the "33.3" even, but it wasnt just any cigarette that you had to smoke, it had to be a newport 100. Some circles said that it was a KOOL.

monstanoodle
08-01-2008, 05:12
i find a hot chocolate after ingesting ms contin crushed makes them come on quicker hahahahaha
melted wax innit

on a more serious note, promethazine works nicely, as does diphenhydramine ... and benzos, and weed... and a glass of wine.
but % is beyond my brain capacity as i'm stoopeed

enoughorangejuice?
08-01-2008, 05:18
hahaha i remember people saying 33% increase of a pot high from stogs...

i think the percentages is an estimate in this thread... or how well they work...

for me...

pot is the best, so 75%
benzos are second 35%
benadryl is third 25%
gabapentin is fourth 10%
alcohol is fifth 7.5%
grapefruit juice is 5%
naproxen is 5%

mikemikemike
08-01-2008, 05:20
Cannabis makes me feel uncomfortable, clonazepam makes me nod, alprazolam takes away the euphoria, and I dont like lorazepam. I have found all the common potentiators; GF juice, benadryl, Cimetidine, to do jack shit.

EDIT: spelling

mukant666
08-01-2008, 05:50
It would have to be be a Newport 100 or a KOOL, LOL!!

I also agree that promethazine increases the effects of opiates especially codeine. Gotta love that syrup!

InHerOwnWrite
08-01-2008, 15:49
IME a mixed shot of opiates and diphenhydramine or promethazine gives a much better rush/warmth than a shot of opiates alone, but im not sure if this thread is only for talking about oral use.

orally, cimetidine has always increased the strength/duration of an oxycodone high for me. i've never mixed promethazine with an opiate orally though.

P.S. i also remember that pot/cigarette potentiator myth from high school, but for us the brand was never specified, it just definitely had to be a menthol cigarette- obviously, everyone knows it wont work with a regular cigarette... 8)

johanneschimpo
08-01-2008, 22:53
So you're saying black stoners get higher than white stoners? Racist...

klowns
08-01-2008, 23:00
duh.....
no maybe he was saying that menthol gets you higher than non menths? jsut a guess.......

johanneschimpo
08-01-2008, 23:28
*whoosh*

did you hear that?







(p.s. clear your PM box so I can talk more shit to you)

Madmike
09-01-2008, 00:01
Ethanol 30-40%
GHB as above
Strong benzos (clonazepam) 50%
Z-hypnotic 10-20%
weed 10-40%
orphenadrine 30-70%
grapefruit juice 70-100% :)
DXM 200%

My tolerance is low.....

Madmike
09-01-2008, 00:04
~1-4%.........cyclobenzaprine (flexeril is a TCA anti-d. muscle relaxant that provides a slight boost)

~1-2%.........loperamide (could easily be a placebo effect)
peace

Lol

Do you get high at all from opioids? :D

Infusion
09-01-2008, 11:14
I would say that diphenhydramine works very well with cannabis and DXM. As far as which one is truly the most effective? DXM... because of tolerance.

I was able to go for a whole month of daily repeated opioid use with my tolerance barely moving at all thanks to DXM. A few months later after significant abstainence without DXM and it skyrockets over the course of like 3 days, regardless of cannabis and dph.

About 2 months later a couple prescriptions for hydrocodone shoot the tolerance into the absolute roof without DXM. Combining with benzos (lorazepam, xanax, valium) probably didn't help. It worked at first, but VERY quickly all aforementioned tolerances skyrocketed and refuse to go down even another 2 months later.

Jphenethylamine
09-01-2008, 15:22
Synergy

I hate smoking weed on an opiate, it ruins my buzz.

Clonazepam or Diazepam if I'm shooting for a nod.

Diphenhydramine IV and a strong opiate IV in the same shot fucking pwns.



I don't have much experience using drugs to potentiate the effects. So i can't say anything about the drugs that accually potentiate by playing with the metabolic pathways.





(p.s. clear your PM box so I can talk more shit to you)


lol :D

InHerOwnWrite
09-01-2008, 15:27
*whoosh*

did you hear that?


i certainly did.

Ham-milton
09-01-2008, 17:42
duh.....
no maybe he was saying that menthol gets you higher than non menths? jsut a guess.......

Jesus christ you're retarded.

Blacks smoke menthol cigarettes at a rate far higher than whites.

Hence the reason that blacks would get higher...

I can't believe this has to be said.

negrogesic
10-01-2008, 21:39
Potentiation implies an increase of blood levels in the target compound (the opioid in this case). Enzyme inhibitors like grapefruit juice and tagamet are actual potentiators.

The other compounds you guys mentioned, like alcohol and benzos cause an additive effect, in that they produce additional CNS depression when combined with opioid...

But i suppose you guys dont really care, i just used to make the distinction when i was here...

rashandreflex
10-01-2008, 21:49
orphenadrine 30-70%


ewwwwwww, worst drug ever in my book.....but to each her own

if you really want a fun night, try chewing one of these....jk.....really, JK....


edit: nothing's really helped potentiate or synergized that will with opiates for me, except more opiates; i also hate weed, so i can't comment on that

Surf N Satch
10-01-2008, 22:23
yetserday i drank 30 oz of pure grapefruit juice 1 hour before banging a 20 piece of H, and the high seemed to be much more drawn out, but not too much more intense.....dunno if that helps....

qwe
10-01-2008, 23:02
my experience:

(1 star) cannabis: completely overpowers the opiate and the mix feels uncomfortable (dysergy)

(5 stars) cimetidine: 400 or 600mg did not do much. then once, just on a hunch, i tried just one tablet (200mg) and my ass was kicked. a small amount of cimetidine potentiates opiates to a huge degree (for myself at least)

(4 stars) clonazepam: increases some aspects of the opiate high like sedation/nodding and the mix is a nice syngery of relaxation

(3 stars) DXM: does a little bit. i mainly use it in regards to tolerance though

(3 stars) antihistamines: works a little bit. an antihistamine/DXM combo (found in many gel caps) is great

StaffWriter
15-01-2008, 19:02
IMO: The best potentiator = carisoprodol. Its the only one I use. 60mg hydro with 700 mg (2 pills) of carisoprodol (soma), aka Vegas Cocktail, is the best. Diphen and benzos dull the high and DXM and gfj never seemed to work for me.

red_eyed_wonda
24-06-2008, 08:06
i heard that klonopin (possibly other benzo's) slow down the break up of opiates. this was from a doctor after i od'd off of 8mg of klonopin and 2 dimes of tar, but then it could have been the respiratory depression because of the combo. and my low tolerance at that time.

gomakemeasandwich
24-06-2008, 09:01
How much do you think certain drugs potentiate opiates?

For example i will list the drugs i use to potentiate opioids (and which opioids) and what percentage of the opioids high i feel (in my experiences) is increased (if at all) by the potentiator.

~20-65%.....cannabis (depending on quality & quantity it can boost the high over 60% especially depending on the strain)

~15-35%.....benzos (in order from best to worst: valium, ativan, xanax, klonopin, librium) i enjoy mixing as many as possible w/ opiates.

~10-40%.....other opiates (not sure if it's considered "potentiating" but the high is boosted for sure, morphine + codeine in PPT is a great combo)

~10-25%.....diphenhydramine (i've only tried up to 25mg)

~5-15%.......hydroxyzine (another antihistamine, i dosed with ~30mg, and it was similar to DPH,)

~5-10%.......alcohol (not sure if i'd consider it a potentiator... but it makes me more buzzed but so does mixing coke + opiates...)

~5-8%.........grapefruit juice (8 oz consumed 60-90 minutes prior dose gives slight boost in effect and duration, but nothing great)

~3-6%.........gabapentin (could be mental, but does work the first time you take it)

~2-10%.......marinol (10-20mg can increase the high, taken 1-2 hrs prior dosing)

~2-5%.........naproxen sodium (aleve, 220-500mg definitely adds a nice subtle warmth)

~1-4%.........cyclobenzaprine (flexeril is a TCA anti-d. muscle relaxant that provides a slight boost)

~1-2%.........loperamide (could easily be a placebo effect)


drugs i'd like to try for potentiation: carisoprodol, DXM, doxylamine, promethazine, barbiturates, and tagamet.


peace

I'm going to disagree with just about everyone here and say that benzos can really add to the opiate/opioid effects...I once took 1mg of Ativan about an hour before a low dose of hydrocodone and the effects were better than a decent dose of IV morphine.

gorgoroth
10-12-2008, 00:34
I really feel like bumping this
my top 8 opiate potentiators

1. Orphenadrine
2. Marijuana
3. Soma
4. Diazepam
5. Promethazine (sic)
6. Cyclobenzaprine
7. Oxazepam (the only thing it's good for)
8. Diphenhydramine

ofukibenhearB4
10-12-2008, 00:47
Cannabis is medicaly proven (well THC that is) to potentiate morphine Drasticaly.
and most people who take opies know this as well, just due to the fact that if you smoke a bowl RIGHT when the opies are starting to kick in, like 20 minutes after an oral dose or directly after a shot....you get WAYYYY fucking higher I mean you can Definatly feel the opiate stronger I mean its amazing how much a difference it makes. I can cut my dose in half if I have cannabis.

Grapefruit juice-For me, this works the best of morphine, or for poppy (seed/pod) tea. and it works Amazingly it definatly about doubles the high for me. Ive never noticed too much a difference with hydrocodone however.

Elavil-Awesome even better than diphen. however It gives me nightmares so I cant take it

Prometh/diphen/dimen/doxy- these all work Realyl well and provided an extra rush and sedation however again, they all give me nightmares so I cant touch them. however if I were to, id take the prometh first, then the doxy, then the diphen shit last

Food-Eating a high fat meal before your opies gives a greater blood level and for me at least it Definatly works but it works the best with morphine/codeine type drugs for me it makes a world of difference, though it also works Wonders for oxy and to a lesser extent hydrocodone

DXM-Do it :)

Benzos make you nod out harder but dont actualy make the opies stronger or anything (except respritory depression wise in which case yes they do ad on to eachother and could kill you....)

Soma-Too much and you wont feel the dope. 1-2 pills and its AMAZING infact hydro and soma and weed is my favorite combo in the world :)
peace hope that helped!

gorgoroth
10-12-2008, 00:54
ewwwwwww, worst drug ever in my book.....but to each her own

if you really want a fun night, try chewing one of these....jk.....really, JK....


edit: nothing's really helped potentiate or synergized that will with opiates for me, except more opiates; i also hate weed, so i can't comment on that

Try Low dose orphenadrine and high dose codeine (nope, don't need anything stronger then that) and tell me if you still feel that way. It doesn't only synergize with it, it actually potentiates it.

ofukibenhearB4
10-12-2008, 00:57
what exactly is orphenadrine? pardon my ignorance

Scootster
10-12-2008, 01:01
Calcium Carbonate - seems to extend it some

Lemon Juice - boosts it a little

Tagamet- makes it more intense for the first hour or so

Grapefruit Juice - same as L juice

Xanex - makes the opioids more dreamy feeling

DXM - adds it's own lil tweak, does more for me if I take it 2-3 hours in

Diphenhydramine - 2-3 hours in, seems to boost the opiate sensation back up a bit

Marihuana - Rocks the combo, sometimes a bit too much

Opium - brings it back a lot, but adds to the sleepies

Coffee - makes the opiate sensation feel more "up"

Percentage? Defining sensations with numbers is hard, I am entirely incapable of quantifying a "feeling" down to a number, I think ( or is it feel?)

ofukibenhearB4
10-12-2008, 01:07
Plus one haha definatly on the whole numbers thing.

Hey id have to agree that coffee and OCs/Norcos with a bowl is Definatly the real breakfast of champions haha

gorgoroth
10-12-2008, 01:08
http://en.wikipedia.org/wiki/Orphenadrine

Scootster
10-12-2008, 01:09
what exactly is orphenadrine? pardon my ignorance

Yeah, what he said, mee too!

ofukibenhearB4
10-12-2008, 01:11
hum sounds like a pretty decent version of diphen eh? says euphoria is Commonly reported.....I bet it feels very similar to elavil....

jon420
14-12-2008, 02:44
Damn n00bs not using the word "potentiator" correctly. :p

Why say this...Its obvious what the guys meant...besides,

potentiate

: to make effective or active or more effective or more active

from mw....

adder
14-12-2008, 03:20
You forgot smoking Atropa Belladonna leaves. It gave me great effects when I was on morphine and smoked Belladonna leaves. The amount is around 200mg but if you can't measure it, just smoke a small amount and go from there.

Contemporarium
14-12-2008, 04:25
IMO: The best potentiator = carisoprodol. Its the only one I use. 60mg hydro with 700 mg (2 pills) of carisoprodol (soma), aka Vegas Cocktail, is the best. Diphen and benzos dull the high and DXM and gfj never seemed to work for me.

I cannot agree with this enough. It nearly doubles the dose in my humble opinion.

rolls
14-12-2008, 05:55
How the fuck can you say it potentiates it 1%? How did you gauge this, did you use 100 people with a control group taking blood samples every 5 minutes?

Sounds like typical drug user hogwash. Half those drugs don't even potentiate opiates they just create a nice synergistic high (which is obvious, generally mixing two drugs will have two highs mixed together).

johanneschimpo
14-12-2008, 06:48
^ Yeah, those numbers are really retarded.

Avalon Star
14-12-2008, 15:59
I'm not exactly an expert but my findings are:

diphenhydramine (125mg) very noticably potentiates my huge dihydrocodeine habit and it also stops the itching skin.

Grapefruit Juice (300mls) potentiates my methadone dose but only slightly.

Cannabis (any amount) really adds nicely to a hit of H.

That's just my experience.

Tchort
14-12-2008, 16:49
Some of the drugs you listed have the opposite effect on opioids. Many Benzo's and Barbiturates decrease the effect of most opioids. They add a synergistic sedation, but by inducing certain enzymes (CYP3A4 mostly), they decrease the total serum levels from a particular dose. They also have the added bonus of increasing your risk of overdose and death from respiratory depression while robbing you of opioids.

ofukibenhearB4
14-12-2008, 20:38
I dont believe that is correct, do you have any referances? All I have Ever known is that benzos and opiates=STRONGER no way in hell I have never heard of benzodiazepines that Induce CYP3A4 why would a drug speed up its own metabolism? doensnt make since to me um Im wondering if what you mean is that they maybe dull or overpower the euphoria for you? for most people it makes for a much more enjoyable time. and again If benzos induced that enzyme (the very enzyme most of them are metabolized by) I would know about it so tell me where you got your info

ofukibenhearB4
14-12-2008, 20:38
phenobarbital, yes that is correct it Is a 3a4 inducer

Tchort
15-12-2008, 17:07
Main Source: Addiction Treatment Forum: Methadone Drug Interactions 3rd edition.

My mistake; seems most Benzodiazepines are competing substrates at the most common enzyme involved in opioid metabolism, 3A4. Barbiturates are 3A4 inducers.

PillPoppingAnimal
15-12-2008, 17:11
I used to laugh so hard back in high school when people said smoking a cigarette after getting stoned increased your high 33.3%
Yes, they said "33.3%"



phrozen: "how much do you think certain drugs synergize with opioids?"

haha i remember it being 7=11% hahahaha