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burn out
14-03-2007, 21:01
how much difference do you think it makes? and does it matter a lot which drug youre taking? i seem to notice a HUGE difference between taking pills on an empty stomach vs a full stomach. now i feel like i am wasting drugs if i don't take them when my stomach is completely empty. of course this makes it very difficult to plan useage around meals.

RorerQuaalude714
14-03-2007, 21:03
You kind of answered your own question; it does make a difference in terms of the speed of onset. As you should know by now, taking pills on an empty stomach basically increases the rate at which they are absorbed, as they are the only stomach contents being digested.

DarkCode
14-03-2007, 21:48
You kind of answered your own question; it does make a difference in terms of the speed of onset. As you should know by now, taking pills on an empty stomach basically increases the rate at which they are absorbed, as they are the only stomach contents being digested.

An empty stomach can sometimes decrease bioavailability, but increase onset and absorption rate. Some chemicals, such as amphetamines, react negatively to highly acidic compounds, such as those found in our stomach fluids, ie: HCl. For some drugs, it can help, and for others, hurt. If your unsure, take a anti-acid, ie: Tums (Calcium Carbonate), it will help, if not be neutral in its action. You should also know ginger ale can help with absorption for chemicals that are negatively influenced by acids.

*When I say negatively, I mean in terms of bioavailability, absorption rate (distribution ratio), etc. Hope that helps.

Survival0200
14-03-2007, 21:48
With some drugs, when you take them on an empty stomach, you get significantly better results, than on a full stomach. For example, diazepam on empty stomach has really fast onset and it's really enjoyable, because it peaks so fast - that's why I never bother to take it on a full stomach.

If you read the summary of product characteristics for the drug in specific, you usually get a pretty good idea of; if you should take it on an empty stomach or on a full stomach.

burn out
14-03-2007, 22:14
With some drugs, when you take them on an empty stomach, you get significantly better results, than on a full stomach. For example, diazepam on empty stomach has really fast onset and it's really enjoyable, because it peaks so fast - that's why I never bother to take it on a full stomach.

If you read the summary of product characteristics for the drug in specific, you usually get a pretty good idea of; if you should take it on an empty stomach or on a full stomach.


yeah diazepam is a great example. for instance, i once took 20 mg on an empty stomach and had a really good time. one day i tried taking on a full stomach and i was not getting affects. i kept taking more til i get up to 60 mg and i still never got the same high 20 mg gave me on an empty stomach, i just felt drowsy and groggy for hours and hours and it was actually an unpleasant experience and huge waste of diazepam.

donkeyPUNCH
14-03-2007, 22:25
ok, so i have a question sorta relating to this but i dont feel like starting a new thread about it.

what about the Opanas? I've read here and on their website that a high fat meal before taking them INcreases their bioavailability. but with food in the stomach, doesn't the onset take longer?

StartedHydro
15-03-2007, 00:34
Taking in a highly fatty food product increases absorption of Opiates. I usually eat a few scoops of ice cream and then ten minutes later my opiates...tend to notice them a little stronger.

RiseFromRuin
15-03-2007, 00:54
I was always under the impression that one should only take vic/oxy on an empty stomach, otherwise it would be sort of a waste. But I have been reading on the board lately the whole fatty food before dosing notion. So on my first try...on a full stomach...I noticed a slower onset (obviously), but somewhat of a stronger high...and longer lasting (again, somewhat obviously).

So count me a believer...not that there was any question as to whether it would "work."

Krowsnose
15-03-2007, 00:59
yesterday I took 3 5/500 vicodin on a completely empty stomach aside from a few chips and some drink. It kicked in within 15 minutes and was probably the strongest experience I've ever had from hc.

MrCream
15-03-2007, 00:59
I enjoy the high alot better if i take my pills on a full stomach of some good food.

MrCream
15-03-2007, 01:00
yesterday I took 3 5/500 vicodin on a completely empty stomach aside from a few chips and some drink. It kicked in within 15 minutes and was probably the strongest experience I've ever had from hc.
yah if I did this the experience would feel really good and strong but only last about 30 min. it sucks

WarmHappyBlanket
15-03-2007, 01:53
eatin pills on an empty stomach is the only way to go IMO
or take the pills then eat right afterwards helps and makes it last a little longer i think

ktx49
15-03-2007, 05:06
considering i debated this problem constantyl during my extremely bad habit of oxycodone daily in doses above 300mg, i can assure u with most OPIATES(namely oxy and hydro), there is no doubt in my mind that an empty stomach is essential for getting the most outta ur opiates.
when id take the SAME dose on a full stomach, i would never get high just very sleepy(which is a big difference).

im not saying u cannot get high with a fully stomach and opiate pills, just that its 110% better to wait atleast 4-5 hours with no food or calorie heavy drinks and take them with atleast 16oz of water!

works like a charm and belive it or not, with the right dosage of oxy, the rush from taking them orally on an empty stomach was very very comparable to the IV rush from heroin.


later guys

ANewKindOfArmy
15-03-2007, 05:41
^I tend to take my pills on an empty stomach, and I started to realize was if I took a couple pills about 15-20mins after getting up, they hit me alot stronger than if i took them later in the day. Say i take 2 10s 15mins after i wake up, ill get a nice buzz on for a couple hours, while if i took 2 later in the day or night it wouldnt do much, maby make me feel kinda warm or feel good for about a half hour to an hour if im lucky ( not saying some days i dont just wait til the night time to get fucked up but when i got a nice supply i tend to take some in the morning and more at night even though redosing pills usually sucks). Anyway my point being oxycodone and hydrocodone seem to fuck me up alot more right after i wake up which leads me to believe this is because of your theory that on a completly empty stomach without any high calorie drinks or anything the oxycodone/hydrocodone hits you much much better. I don't usually take it down with 16oz's of water but im definitly going to give it a try tommrow morning. Im glad you brought that up.

Be safe and thanks,

- B

smackem
15-03-2007, 06:19
Some guys will tell ya, you are taking the same amount of drug, only difference would be the rate of absorption. I would tend to agree. However; in the RX information given to patients and doctors it says the medication might not be as effective taken on full stomach (hydro). I am not certain if this is done by a double blind study, or taking blood concentration. I am also not certain if they mean you just won't 'peak' and its more slow absorption or you auctually get less drug.

What I do know is simply, the RX companies fda approved statement is, pills (hydro/perc/adderall/dexadrine all of those I have read for sure)can be not as effective when taken on a full stomach

ktx49
15-03-2007, 15:35
^yep.

my pamphelt from CVS for my oxycodones tells me to take them on an empty stomach which i found really strange cause thats really what u do when ur trying to get high lol!

even the pharm-assistant reminded me to take on an empty stomach with water!!

however, i must admit that if u are taking ur pain pills for legit pain and could give a rats ass about a buzz, then dont even bother; ive found them to be equally effective for pain with or without food....only difference being the rate of absorbtion aka how long they took to work.

later

thujone
15-03-2007, 16:04
when i see 'full stomach,' i think 'steak dinner.' I prefer having a bit of a nosh before dosing but not too much to put my digestive system into overdrive. the pills take a bit longer to take full effect, but it's worth not getting nauseous

StaffWriter
24-03-2007, 05:50
I always take my hydrocodone (60-70mg at a time with 2 soma) on an empty stomach to get the best bang for my buck. Unless you're prone to nausea, I would suggest you do the same to feel the full effects. As for other types of drugs such as amphetamines, I would not know.

melange
24-03-2007, 06:33
I take alot of pills everyday as it is, not even counting the ones for recreation


I usually take them on a full stomach because I already get pretty bad heartburn as it is, and taking them with food helps alot

smokeymcpot42088
24-03-2007, 19:14
IR Oxycodone actually does work better if you have a high fat meal.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8901078&dopt=Abstract

http://www.drugs.com/ppa/oxycodone_hydrochloride.html
"Peak plasma concentration increased by 25% with a high fat meal"

IR Morphine also has a higher peak plasma level after a highfat meal. (under nutrition/herb/ethanol section)
http://www.merck.com/mmpe/lexicomp/morphine%20sulfate.html

Controlled release versions of each show on difference. However under the Morphine it says alcahol can disrupt the time release...

RastaFly69
25-03-2007, 17:19
works so much better on an empty stomach..thats the only time i'll take them

RiseFromRuin
18-04-2007, 21:48
just a quick q on that PubMed article....

Obviously OxyContin is not the same as Roxicodone (ER vs IR), but for the purposes of the article, if you crushed the Contin and parachuted it, is this getting pretty close to IR

Basically I'm asking if you parachute a powderized oxy, is it the same as swallowing a roxi?

RorerQuaalude714
18-04-2007, 21:51
^Essentially, since the oxy's time release mechanism would be defeated by crushing it.

fuzzywuzzy123
19-04-2007, 11:05
so what is the best high fat food to take before parachuting oxys?

MrCream
19-04-2007, 12:17
I like to take my pills wait 15-25 min then eat a full meal. Makes me less nausious from strong doses and seems to still make them kick in faster and last longer because they are in the bottom of my tummy (or lower in my digestive tract) and my food is 15-25 min behind it :P Best way to do it imo :P Someone on here give this ^^ a try and let me know what ya think :P <3

collosssus
19-04-2007, 13:14
so what is the best high fat food to take before parachuting oxys?


A 1/4 cup of oil, vegetable, sunflower, olive, etc.

The reason for this is that opiates need to be dissolved in fat in order to break through the BBB (blood brain barrier). I would assume that oil would greatly enhance a crushed oxy high.

Druggist
19-04-2007, 17:53
I like to take my pills wait 15-25 min then eat a full meal. Makes me less nausious from strong doses and seems to still make them kick in faster and last longer because they are in the bottom of my tummy (or lower in my digestive tract) and my food is 15-25 min behind it :P Best way to do it imo :P Someone on here give this ^^ a try and let me know what ya think :P <3

I like to take my drugs on a completely empty stomach and then smoke some weed right after the pills start kicking in, usually about 45 minutes later. Then I lay down for about 15 minutes and enjoy the opiate/weed high. Thats when hunger hits me like a ton of bricks. It usually starts as a slight nauseous feeling but quickly turns to hunger(if i dont eat soon after that feeling i start to feel real nausea). Then I eat and I feel great for the next few hours with no nausea at all, no matter how large of a dose I take.

darkestclear
19-04-2007, 18:38
The big secret for potentiating some opioids,mainly oxycodone is eating some form of pork about 20 minutes before.(pork,ham,pork chops etc). This increases the bioavailability by about 15-20%. This works for me more than any other method(benzos,tagament,grapefruit juice etc).

Beans
19-04-2007, 18:59
^^thanks for giving me another excuse to eat bacon 8)

Since this has turned into taking opiates on an empty stomach vs full stomach I'll weigh in. For those who have issues with nausea it is always best to have something in your stomach when you take your dose (not a steak dinner but something solid).

There is no doubt that an empty stomach equals a quicker onset but not necessarily higher bioavailability. Like mentioned earlier, fatty foods right before opiates will increase bioavailablity when taken orally. This doesn't mean you need to clean out McDonald's beforehand... :D

RiseFromRuin
19-04-2007, 19:52
I'm not drinking olive oil, but I'll eat some slices of ham.

mikemikemike
19-04-2007, 20:17
For me, it is best to eat a moderate meal, like a snadwich with no sides, about 3 hrs before ingestion. If you need to eat it sooner than that, eat something small, like a 5 piece nugget, and wait an hour or so, this will prevent the stomach pains and hunger induced nausea while on.

visualvalium
19-04-2007, 20:23
i know this goes without saying but plugging the opiates makes this a moot point. if i have just eaten ill even prefer to plug my benzos and ambien so theyll kick in faster, as orally i wont feel them at all. but id say if you take them orally eat after the pills have digested, like thirty minutes later, as with the opanas you eat either two hours before or an hour after taking them, but either way its on an empty stomach. something to do with fat absorption. im not sure if eating affects plugging route though, but food can increase gut motility and blood concentrations of fat and protein which can effect drug action.

SonOF
27-04-2007, 00:13
considering i debated this problem constantyl during my extremely bad habit of oxycodone daily in doses above 300mg, i can assure u with most OPIATES(namely oxy and hydro), there is no doubt in my mind that an empty stomach is essential for getting the most outta ur opiates.
when id take the SAME dose on a full stomach, i would never get high just very sleepy(which is a big difference).

im not saying u cannot get high with a fully stomach and opiate pills, just that its 110% better to wait atleast 4-5 hours with no food or calorie heavy drinks and take them with atleast 16oz of water!

works like a charm and belive it or not, with the right dosage of oxy, the rush from taking them orally on an empty stomach was very very comparable to the IV rush from heroin.

later guys

I agree with all of that. ^^^

adder
27-04-2007, 01:12
That's why I switched one day to shooting codeine if somebody asks me again.

jstb0b
16-04-2009, 21:38
For me, I cook up 3 slices of bacon 30min to an hour before ingesting an opiate. It works quite well (especially with pod tea).

Desdenova
16-04-2009, 23:10
I've found that the most effective way to take my Percocet is to take them, and then eat, whether a snack or a meal

mrskatanic
15-05-2009, 03:22
Does snorting them on an empty stomach (or full) make a difference? i mean, i know a bit drips down into the stomach. but is the effect like a metabolic thing or is it only in the stomach that this takes place?

pillpopper187
15-05-2009, 04:20
so what is the best high fat food to take before parachuting oxys?

bacon?

Floaters
15-05-2009, 23:27
Does snorting them on an empty stomach (or full) make a difference? i mean, i know a bit drips down into the stomach. but is the effect like a metabolic thing or is it only in the stomach that this takes place?

Full stomach vs empty makes no difference when snorting. Actually, that is the only reason I snort. I don't like the effect near as good as eating oxy. However, eating a 15 mg oxy ir on a full stomach does ABSOLUTELY NOTHING for me. On an empty stomach, it gets me fucked up.

JahRed24x
16-05-2009, 01:34
The best way to take opiates especially is to take them on an empty stomach then about 5min-10mins later eat a a light high fatty meal and it will increase the effects and absorption. Cuz then when the food hits ur stomach with the pills in there already it kick starts your digestive system and basically will increase the effects of the opioid/opiate.. I think this concept of taking your pills and then 10mins later eating a light fatty meal will work for most pills. But yeah always eat your pills on an empty stomach first then eat a light meal and it will kick-start ur digestive process and just make it hit you even faster.

Local808OPANA
01-11-2010, 01:34
A 1/4 cup of oil, vegetable, sunflower, olive, etc.

The reason for this is that opiates need to be dissolved in fat in order to break through the BBB (blood brain barrier). I would assume that oil would greatly enhance a crushed oxy high.

ASSHOLE QUIT TRYING TO MAKE POOR IDIOTS DRINK OIL... cant u suggest sum chips or bacon? if u were smart ud pound a bunch of scops of mayonaise b4 dosing

RedBaron
01-11-2010, 02:15
I certainly find an empty stomach to bring on stronger effects (except snorting, works either way for me).

And, yeah, 1/4 cup of oil is a bit much, a tsp up to a tbsp of oil would be just fine.

I like to have a real good empty stomach (right before dinner, no snacking since lunch), and I take a tbsp of flaxseed oil with my dose.
Of course I go for the whole plethora of potentiation (cimetidine, quinine, dxm, etc), so it's kind of hard to say how much of a difference the oil makes, but an empty stomach for me can make or break the intensity.

Cloudnine2727
21-03-2011, 07:48
I chewed up one vicadin on an empty stomach an hour after I woke up and an hour into it I had a seizure, the first I have ever had. I have taken it before for wisdom teeth, even 3 at a time. So just be careful. You can never be sure

laCster
22-05-2011, 02:35
if i took methadone 2hrs after eating, how many hours will it take to achieve the peak?? was this waste?? will i even feel anything?

SM420
22-05-2011, 05:44
It can also depend a lot upon your metabolism. If you digest your food really quickly, you'll still probably get most of the effects that you would on an empty stomach, just with a much slower onset. Despite having a fast metabolism, I prefer to ingest pills on an empty stomach not only for the quicker onset, but because the effects seem to be somewhat dulled, like the "edge" is taken away from the substance. That being said, if I eat a meal immediately before ingesting pills, I usually feel the effects after about 60-90 minutes.

sayvar44
13-12-2011, 16:26
with codeine it helps having an empty stomach and chasing it with a hot drink especially coffee, as for valium it feels like it kicks in better on an empty stomach but you gotta eat after a while or you end up forgetting to eat at all! and wake up exhausted drained

neutrophilis
13-12-2011, 23:58
60mg Oxazepam - 3-4 hrs onset which gave some strange eupohric kinda untouchable vibe stayed with it for an hour or so on empty stomach. Decided to eat 4 marmite toasties and make a cuppa, ingested another 30 mg bout twenty minutes after, now i dunno if it was them toasties what did it but boy i felt smashed within an hour, like 100mg diaz smashed, fell asleep after that couldnt even be bothered to make some tea and smoke a ciggie!

Ingested bout 105mg so far today started early, have not eaten as yet, took 60mg around 7pm uk time, nothing like last night feeling that same sort of euphoric untouchable vibe, of to make some marmite toasties and tea.

fivelinefury
14-12-2011, 01:45
I've quite often noticed a big difference with codeine kicking in a lot harder for me on an empty stomach. Used to also notice with benzos, but don't really notice any difference anymore, due to tolerance.

Coraline
14-12-2011, 05:33
I take my hydrocodone and zantac on a empty stomach. If I don't take the Zantac I'm doubling over in intense pain. Idk if it's from the soda or hydrocodone. But anyways, I have noticed a difference on a empty stomach. It is rapid and very intense in 15 min.

neutrophilis
14-12-2011, 18:23
Nah Marmite toasties failed last night, What a shame i thought id come up with some kind of amazing marmite chemical reaction with a certain Benzo. Anyway no more perscribed Benzos for me my Doc thinks i have some form of Schizophrenia and after researching it for about two hours last night i tend to agree. Psycotherapy and Anti-Pyscotics here i come......Y0, Fcuk that, On a positive note.....I do a luv a marmite toastie!