PDA

View Full Version : (opioids) Loperamide (Immodium) Megathread: We have now lost at least 2 of our own from Lope



Pages : 1 [2] 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21

ClubbinGuido
09-03-2007, 06:30
clubbinguido - it doesn't matter what you do with loperamide. just having an opioid receptor affinity doesn't make a drug euphoric. and loperamide isn't going to give you heroin style highs.

- amar


Indeed. Correct me if Im wrong but isnt a majority of its opiod receptor affinity in the intestinal tract of the body? And this is why it wouldnt be euphoric anyways even in large amounts aside from the fact it doesnt readily cross the blood brain barrier correct?

ClubbinGuido
09-03-2007, 06:38
probably a wikijoke!


It has to be. From what Amar has stated and the research I did in threads on this site and articles on the web it has to be placebo. Granted Loperamide does help with opiate withdrawal, Im coming to the absolute conclusion its absolute bollocks to be able to get high on this OTC drug. You got to think this way too, opiates and opiods are so tightly regulated here in the United States why on earth would they market an OTC opiod that might have the potential to become recreational with some at home do it yourself chemistry?

robatussin
09-03-2007, 19:30
Shameless bump.

Any more experiments with this stuff?

RiseFromRuin
09-03-2007, 21:22
why on earth would they market an OTC opiod that might have the potential to become recreational with some at home do it yourself chemistry?

Why on earth would they market (pseudo)ephedrine as a dietary supplement, when it might have the potential to become brain destroying with some bathtub do it yourself chemistry.

HYDRO_CHRONIC
09-03-2007, 22:40
um why is it so hard to believe it gets some people high ,it say7s some symptoms on the back ,that you might feel ,and they are opiod realated

just cause YOU cant get high from it doesnt mean somone else cant ,i think this has gone on enough

and if you found a way to MAKE the shit work for you ,why post about it so they can take the shit off the fucking market ....un real!!!

dbailey11
10-03-2007, 08:50
Like I said in an earlier post, after some extreme stomach pain and having to puke four times, it produced a similar feeling to 2-3 hydrocodones. It was alot longer lasting though. But it was definately NOT worth trouble. If you don't think I'm telling the truth, whatever.
You can always see for yourself, but be prepared to really pay for your buzz.

haribo1
11-03-2007, 20:49
Monkies were made into dope-fiends and researchers found they would take loperamide over a placebo to help withdrawal. I've gone to the trouble of posting nice clear diagrams, methadology & facts & figures concerning this subject. I would post links to the original patents but it doesn't seem that anyone gives a flying fuck about the actual chemistry. It used to be a free country, so feel free to ignore, but it is NO just a question of it passing the BBB. It's binding the the CNS mu receptors is rather low. Maybe if you do enough then you can blockade those receptors and, like buprenorphine, it has some agonist activity, but it's obviously highly subjective as to what IS a good high. If I don't see elves in 10 seconds, I usually don't bother.

IHateOpiophobes
14-03-2007, 10:05
Fractal...

That was about the funniest thing I have heard in a while. Probably because I could see some idiots really calling them that.

Polysorbate 80 is available in BULK for cheap online. Just do a search for it.

Loperamide can get by but it takes quite a bit. It wouldn't be worth the all the pain except maybe isolating it and snorting. If I ever have the joy of withdrawals again I'm going to get some just to hopefully feel better.

haribo1
14-03-2007, 10:12
With that bare hydroxyl, I don't think it will be active. Like I said, you need to remove that Cl group to increase mu binding by a factor of 40. NaBH4 should do the trick. Esterifying the hydroxyl would need propanoic anhydride (which you can DIY from sodium propanoate but it's a bit of a pain). Look at related drugs. Add or remove 1 carbon from the ester and the potency dives so it IS important to potency...Look at diphenoxylate, that's a non-reversed ester so it's the acetate. I spent a LONG time investigating loperamide and colcluded that if you do all the tricks I mentioned, you could get a compound about 50% as strong as morphine. Is it worth the trouble? Maybe if you can get all the ingredients dirt cheap...

Beans
14-03-2007, 15:51
yeah because i'd definitely feel more comfortable purchasing the industrial sized bottle of an anti-diarreah medicine everyday rather than scoring real drugs from my hookup

itsjustme
14-03-2007, 16:36
^ aaahhahahhahahaahahha

MDPVagrant
14-03-2007, 17:21
From Wikipedia:

Also, it may be possible for loperamide to bypass the blood brain barrier completely through insufflation.[3] Recreational users may attempt to isolate the loperamide from the inert fillers through a typical cold water extraction, and then snort the resulting material.
Interesting that they'd say this, as loperamide is only slightly soluble in h2o, but freely soluble in alcohol.

Curiosity got the better of me this morning... found three 2-mg tablets of loperamide lying around and did a "cold alcohol extraction" using 99% isopropyl followed by evaporation. Just insufflated the results (which was VERY easy after removing probably 98% of the pill crap) -- nothing conclusive yet, but I certainly haven't gotten any strong opiate rush or anything :p. There's a bitter drip at the back of my throat, that's all I really notice so far.

I have a moderate dependency on kratom, so you could say my opiate receptors are probably a bit desensitized... we'll see what happens (hopefully not severe constipation, but I doubt it from snorting < 6mg). Will update this post with anything definitive.

Edit -- feeling an undeniable opiate buzz, with some euphoria. It isn't exactly powerful, but it is there. Off to the store to pick up more loperamide... will try this again soon. If anyone wants details on exactly how I did the extraction, let me know.

DopaMan
14-03-2007, 18:54
I would like some details and I think many people on the board would too. I don't think haribo's discussion of synthesis is allowed here but extraction sure is. No offense haribo what you are saying is great but its not what the board is about.

MDPVagrant
14-03-2007, 19:23
(1) Grind the pills to a powder.
(2) Add to 99% isopropyl alcohol and dissolve.
(3) Put the solution in a container and let sit in the refrigerator for about a half hour (solids will fall to the bottom).
(4) Siphon off the alcohol (eyedropper works fine) and put on an evaporation plate.
(5) Evaporate in a microwave or using a blow-dryer.
(6) Scrape up resulting crystals and snort.

I just did it again with a few more pills, and this time the powder is irritating the f*ck out of my nasal passages... very painful. didn't do it last time for some reason. Wonder if it was a different brand of pills, & these ones contain some sort of irritant(?).

Edit -- actually ended up with a stuffy nose = swollen nasal passages... be careful out there...

malfunkshun
14-03-2007, 23:49
very interesting thread. i've used loperamide to cope with WD's, but never more than 12 mg at one time, and all it ever did was stop bowel trouble. i always felt exactly as much like shit physically as i would have had i not taken the loperamide... just minus the runs. next time i'm in WD's (lol... next time. i'm sure its gonna happen again soon) i'm definitely gonna try this with the GF juice. i think i won't go over 24 mg though, and i ain't snorting them.

erosion
14-03-2007, 23:53
A good friend of mine swears by loperamide in combination with cimetidine (an otc enzyme inhibitor). He claims that a dosage of ~20mg of lopermide feels like 10mg of oxycodone. I did try this once a year ago while nontolerant and I did get high, though it was very subtle.

Search for posts by thetripdoctor and loperamide if you need more information.

BANGINCOLOR
15-03-2007, 00:10
Man, you guys remind me of myself back in my 20's.....doing whatever I could to hook up with some pills and have fun. The one guy eating a bunch of immondium and going from bad to worse and thinking his stomach was going to blow a gasket.....had me laughing for an hour!!! Not laughin at ya....laughin with ya cause that was me 12 years ago.

Know what I ended up doing?? I found my hospital records from a car accident I had 20 years ago and I used them to go to a REAL doctor and get 120 count of 10mg/325apap percocets!!!

Actually, I also was left with a fucked up back from the accident and when I had insurance, I went and got an MRI. Hurray for me, they found TWO herniated discs!!!! Now I get 120 count of 80mg oxycontins and 120 count 30mg roxicodones!!!! Fuckin sweet!!!!

As you can see, this is my first post and reading this thread gave me a ride down memory lane. If I could go back and talk to myself in my 20's, I'd say either find some old doctor records from something and go to a REAL doctor and get REAL pills. We all had to go to the doc at one time or another for something, right??

Worst case, roll your car 6 times like I did. Have the roof of your car cave in and crack your dome, break your C3 and almost die. THEN you'll get the pills you want!!!!

malfunkshun
15-03-2007, 00:38
or, you could just buy some pods legally and not even have to hassle with a prescription. oh you don't have to be injured either, thats a plus

BANGINCOLOR
15-03-2007, 00:54
or, you could just buy some pods legally and not even have to hassle with a prescription. oh you don't have to be injured either, thats a plus

Yeah but where's the fun??? :)

What pods? Where do you get them?? Are these the pods where people try and make opium tea or whatever??

I'll stick with the roxis.

erosion
15-03-2007, 02:11
Yeah but where's the fun??? :)

What pods? Where do you get them?? Are these the pods where people try and make opium tea or whatever??

I'll stick with the roxis.

Do NOT ask for sources, and use the search engine if you want to know more about pods.

MrCream
15-03-2007, 02:14
Do NOT ask for sources, and use the search engine if you want to know more about pods.
yah give him a break since hes new, but yah bro you can't ask for any sources AT ALL PERIOD here.

erosion
15-03-2007, 02:21
I won't give him a break. This rule is set in stone, and isn't tolerated in any situation.

haribo1
15-03-2007, 02:26
A good friend of mine swears by loperamide in combination with cimetidine (an otc enzyme inhibitor). He claims that a dosage of ~20mg of lopermide feels like 10mg of oxycodone. I did try this once a year ago while nontolerant and I did get high, though it was very subtle.

Search for posts by thetripdoctor and loperamide if you need more information.

Cemitadine is used to enhance the effects of many drugs. Peoples brain chemistry & tolerance seem to be important here. Anyone with any kind of tolerance doesn't get off on it at all, but some opiate-nieve people say they get a buzz. Well, I'm not going to say it's placebo but I would be interesting to know just WHAT is going on.
Snorting will not sort the BBB problems since it only gets it into the blood. Wiki, especially chemistry bits, is notoriously unreliable.

erosion
15-03-2007, 02:37
It doesn't cross the bbb, but ive seen much anecdotal evidence that it has effect. There could be some sort of periphral effect... Who knows. Hows drugs effect the brain and body aren't fully known, and there could be some mechanism that causes action indirectly. Claims about it should be taken with a grain of salt, but shouldn't be discounted entirely.

RiseFromRuin
15-03-2007, 02:38
Ok now that this supposed step by step guide to getting high with easily attainable ingredients has been posted...let the onslught of loper posts begin...

I haven' tried it out...but I might. 6mgs snorted vs. oral w/cimet. I'm sure there will be a case versus case experiment considering the ease of acquiring all of it is...

TripDocs Thread http://www.bluelight.ru/vb/showthread.php?t=254662

AmbientDreamer
15-03-2007, 02:38
Interesting thread. The p-glycoprotein inhibition from the flavanoid in the juice definitely seems like feasible explanation to make it cross the BBB. The best way to assure the CNS effects all the time would be to cut off the Cl- anion to decrease the polarity of the molecule like Haribo said or use the detergent method of polysorbate.

If kids really start getting their chemistry together I can really see Fractal's prediction becoming a reality. "Tonite on the 10'o'clock News - Another Lope lab is busted!"

RiseFromRuin
15-03-2007, 03:33
Here's my vote for the street name..

"Loopy Loo"

Sell like hotcakes yo

TheTripDoctor
15-03-2007, 09:48
I'll suppress being pissed at morons trying to get high for the moment for some real discussion.

Taking loperamide in excess like that, especially in someone who has no tolerance to opiates, can cause a number of problems, none of which are enjoyable, funny or trivial. It should be noted that all opiates can cause problems like this, but using large amounts of loperamide carries the most risk for a number of reasons.

The following problems can occur:


1: Slowed or stopped bowel motility in an opiate naieve user will in some cases cause a bowel perforation. Symptoms will be extreme abdominal pain which gets worse with movement, sweating, vomiting, and an massive infection due to bacteria being released into the body. This requires hospitalization and in some cases results in death.

2: Toxic megacolon, this is a distention of the bowel which can lead to perforating the colon, septic shock, and a number of other serious problems, in many cases it requires removing the colon entirely.


It isn't fun in any case, there are other opiates available.

haribo1
15-03-2007, 15:28
Diphenoxylate has been discontinued because of toxic megacolon. All opates share thise risks to an extent, but since these are MADE to bung you up, they are the worst.
I will find a link to the mu activity/structure guide. Removing that chlorine is VERY important to central activity and I'm betting that quat alcohol needs esterification.

BANGINCOLOR
15-03-2007, 15:42
I won't give him a break. This rule is set in stone, and isn't tolerated in any situation.

I was 99% sure what pods he was referring to, I just wanted a clarification plus, why would I waste my time purchasing pods when I have all the oxycodone I could ever want legally prescribed.

Rules set in stone??? This whole thread is about snorting loperamide to get high and you're worried about LEGALLY purchasing pods???

erosion
15-03-2007, 16:19
Rules set in stone??? This whole thread is about snorting loperamide to get high and you're worried about LEGALLY purchasing pods???

Rule 1.1 of the Bluelight User Agreement (http://www.bluelight.ru/vb/faq.php?faq=about#faq_agreement):

1. attempting to solicit or obtain contraband substances or substances of a quasi-legal status; or information on how to do so;

Asking where you can buy pods violates this rule.

Read the BLUA in its entirity and look at our forum guidelines. We don't have millions of rules, but the ones we do have we enforce, and asking for sources is strongly enforced. I am not out to get you, just informing you of our rules.

Please respect them.

BANGINCOLOR
15-03-2007, 18:41
Rule 1.1 of the Bluelight User Agreement (http://www.bluelight.ru/vb/faq.php?faq=about#faq_agreement):

1. attempting to solicit or obtain contraband substances or substances of a quasi-legal status; or information on how to do so;

Asking where you can buy pods violates this rule.

Read the BLUA in its entirity and look at our forum guidelines. We don't have millions of rules, but the ones we do have we enforce, and asking for sources is strongly enforced. I am not out to get you, just informing you of our rules.

Please respect them.

Well, there's nothing quasi-legal about it, purchasing pods is 100% LEGAL so it's impossible to break any rules talking about it's purchase.

I'm not worried about anyone and I do respect and want to follow the rules here.

Cheers!

malfunkshun
15-03-2007, 19:53
Well, there's nothing quasi-legal about it, purchasing pods is 100% LEGAL so it's impossible to break any rules talking about it's purchase.

I'm not worried about anyone and I do respect and want to follow the rules here.

Cheers!

if you ever get caught by the cops with a brew of pod tea, or pods crushed into powder, or pods in any form that obviously is meant for consumption, thats a felony. i'd say that qualifies pods as quasi-legal.

BANGINCOLOR
15-03-2007, 20:05
if you ever get caught by the cops with a brew of pod tea, or pods crushed into powder, or pods in any form that obviously is meant for consumption, thats a felony. i'd say that qualifies pods as quasi-legal.

AGAIN, ordering of said pods is LEGAL. If I got caught ordering pods threw the mail no one could do anything about it anywhere. Nothing quasi-legal about it.

malfunkshun
15-03-2007, 20:08
Rule 1.1 of the Bluelight User Agreement (http://www.bluelight.ru/vb/faq.php?faq=about#faq_agreement):

1. attempting to solicit or obtain contraband substances or substances of a quasi-legal status; or information on how to do so;

Asking where you can buy pods violates this rule.

Read the BLUA in its entirity and look at our forum guidelines. We don't have millions of rules, but the ones we do have we enforce, and asking for sources is strongly enforced. I am not out to get you, just informing you of our rules.

Please respect them.

you must have missed that post, bangincolor. why be a douche about it? just respect what the mod says for crissake 8)

sixpartseven
15-03-2007, 23:12
AGAIN, ordering of said pods is LEGAL. If I got caught ordering pods threw the mail no one could do anything about it anywhere. Nothing quasi-legal about it.

Just give up. Its the fucking rules and they arent going to change no matter how many little loop-holes you try to find in them. If you dont like the rules here, then stop posting here, no one is forcing you to.

And the reason we can discuss this topic (getting high off loperamide) is because this website is based on gathering and sharing information for safe(er) drug use. Its better we discuss this and learn everything we possibly can about it so that if someone decides to try and get high off it they have all the information they need to stay safe as possible.

Discussing this and discussing sources are two different things and its ridiculous to try and compare the two. Were here to keep you safer, not to "hook you up."

DIRTYMAN
17-03-2007, 12:23
very interesting thread. i've used loperamide to cope with WD's, but never more than 12 mg at one time, and all it ever did was stop bowel trouble. i always felt exactly as much like shit physically as i would have had i not taken the loperamide... just minus the runs. next time i'm in WD's (lol... next time. i'm sure its gonna happen again soon) i'm definitely gonna try this with the GF juice. i think i won't go over 24 mg though, and i ain't snorting them.

Has anyone else tried to use lope to kick opiates?


Right now I have about a gram a day tar smoking habit that I'd like to stop completely. I had my last balloon today so tomorrow will be the first day going cold turkey. I have 2mg klonopins to help with the anxiety (which does greatly) but was wondering if there was any hope of drinking a potentiator like grapefruit juice and snorting a loperamide extraction (CW or alcohol) to rid some of the other WD symptoms.

Symptoms include headaches, major anxiety, depression, fatigue, hot/cold feeling, pins and needles under the skin, and the intense desire to use again. I don't think I have a major habit cuz my joints don't ache, there's no explosive shits and I can ignore the physical pain with some good weed.

Anyone have personal experience, or am I going to be another guinea pig?

DIRTYMAN
17-03-2007, 23:31
Well I took 6 mgs of AD syrup this morning along with 1 mg of clonazepam and I'm feeling fine. I'm hoping to score some grapefruit, tagamet or clonidine to potentiate and see if this really is "OTC methadone", but right now my first day is going well and I don't feel like killing myself from WD's. Me and my girl are adamant about quitting and have tried cold turkey before, so we'll let you all know how it goes.

amar_g
18-03-2007, 01:30
it won't erase all the problems like methadone will, but it will DEFINITELY bring the withdrawals back down to 'tolerable' and, if you keep yourself busy like i did when i quit, you'll be surprised how helpful it can be.

- amar

ps - re-quitting starting today.

robatussin
18-03-2007, 04:40
Ok i have done some experimenting, although i do not advise anyone to do what i have done, i fell i should share the results.

First i should share my background. I was addicted to heroin a couple years ago. Although I am not physically dependant on any opiate at the moment, i do feel i have somewhat of an accumulated tolerence.

After reading this thread among others along with outside sources, I felt i should experiment with high doses of loperamide due to my lack of dependence on opiates.

3 nights ago i preformed a simple alcohol extraction using 80 mg loperamide. The method i used was not exact my any means so i probably lost some product in the process. I felt like i had done an opiate and believe me i know what an opiate feels like. I was drinking that night however, and decided against posting anything about it due to the fact that it could have been placebo or whatever.

Tonight i did the same extraction using 100 mg of loperamide after the 80 mg dose did next to nothing to stop any bowl movements. Before consuming the extract (intranasily), i had a huge headache that made me want to go to sleep for the night. After snorting my concoction, the migrane was all but gone, and i have the tingly opiate running through the veins feeling. I read from an oustide medical source that .04% of loperamide crosses the BBB (without anything to increase the absorption). However it is not fair to say that 4mg crossed my BBB beacuse the extraction was not exact, and the loophole in the BBB via the olfactory system is not calculated with loperamide. I would just like to inform anyone concerned that after what i have done, i have found loperamide to be very mildly recreational to non tolerant opiate users, and a good aid in withdrawl(i have used it orally during withdrawl years ago). I feel that i have said more than anyone needs to know, and keep the flames to a minimum. Hope this helps the discussion, if anyone feels the need to ask anything else, PM me.

swybs
18-03-2007, 04:54
^^^ I have to say placebo, since--even at high doses--studies have come up inconclusive (although they were oral, and you say intranasal?). While super high doses of loperamide have helped me through some mild WDs, at what cost? I dont think anyone here (or any other forum) has been able to say what kind of physical damage is being done if someone is taking extreme doses (100 mg is extreme). Granted, the obvious occurs, but I'm not 100% confident that constipation is the only effect.

malfunkshun
23-03-2007, 02:00
Ok now that this supposed step by step guide to getting high with easily attainable ingredients has been posted...let the onslught of loper posts begin...

I haven' tried it out...but I might. 6mgs snorted vs. oral w/cimet. I'm sure there will be a case versus case experiment considering the ease of acquiring all of it is...

TripDocs Thread http://www.bluelight.ru/vb/showthread.php?t=254662

that links me to an invalid thread. whats the deal?

anywho, i was wondering, instead of snorting it, could you plug it instead? if it does happen to cross the bbb in some small way by snorting it, and if plugging it would produce the same result, i'd rather plug it than putting all that crap in my nose.

ifonly
23-03-2007, 03:04
yeah. ive never had constipation from any form of opiate, i can use a half gram of codeine daily for a week and still take a nice shit at the end of each day.

id like to try this, its just that funding is low atm and i dont know how to get tagamet or quinidine from asutralia. i would ask at a pharmacy but its likely theyd ask what i need it for and even if i told them theyd prolly be sus about asking for exact chemicals. id skull a litra of grapefruit juice but supposedly thats not as good as proper tagamet or whatever.

anyway if i find some info on potentiators or happen to try something, ill post here. my opie tolerance is hardly anything, i nod off codeine every time.

also malfunkshun raises a good point about plugging....

malfunkshun
24-03-2007, 19:42
i have definitely had success with loperamide, at a 30 mg oral dose. check my recent trip report.

http://www.bluelight.ru/vb/showthread.php?t=299226

mrt50-NL
24-03-2007, 20:19
who the hell prescribes this kind of stuff, and what for??? doesn't really make sense. maybe a quick look-up on wikipedia will help me:D

edit:

thanks, mr. wiki:

When loperamide is taken by itself, it cannot readily cross the blood-brain barrier; however, when loperamide-containing nanoparticles are coated with polysorbate 80 and injected, the results were the same as typical opiates and opioids -- long, effective analgesia. A solution prepared using loperamide coated with polysorbate 80 resulted in a very short duration of action and less effective analgesic effect.

The same study concluded that loperamide does not cause any analgesic effects when taken by itself.

Also, it may be possible for loperamide to bypass the blood brain barrier completely through insufflation.

Recreational users may attempt to isolate the loperamide from the inert fillers through a typical cold water extraction, and then snort the resulting material.

malfunkshun
24-03-2007, 20:30
well, here in the states, its not a prescription drug. aka immodium ad

cashtothemoney
17-05-2007, 07:27
Here's a link to a chart with the agonist/antagonist properties of different opioids... loperamide is indicated as on the lower-side of having moderate-to-weak agonism. It acts as a mu-opioid agonist, and a kappa- and delta- agonist at high doses. This chart is actually gathered from a pharmacology handbook available at B&N. I've seen it before... I wish I could remember the name. When it comes to me, I'll post it here.

http://www.thatspoppycock.com/library/receptor_activity.htm

Crimethink
17-05-2007, 20:50
First off Loperamide is formulated with Magnesium Stearate which is highly insoluble in water. Stearates break down on exposure to even mild acids & heat.

Alot of people think you can grind up Lomotil & water extract the atropine. (Keep in mind atropine is less commonly used along with PTC in bitter principle taste-tests) Not only is a water extract of 60 Lomotil tabs (2 mg atropine) tasteless but it has nil-to-no anticholinergic effects.

Now if you take that Lomotil soln. mix with a small amount of hcl or vinegar and microwave to heat to ~180&#176;F you go from having a flocculent solution of large hydrophobic white particles to a solution where the particles appear to have 'unfolded' and are nearly transparent and obviously interacting with water. And of course the solution is very bitter. Separating the 2 compounds is another issue.

(http://opioids.com/loperamide/index.html)
It was concluded that in its present form, i.e., capsules containing loperamide mixed with magnesium stearate, loperamide poses little threat of potential abuse.

As for Cimetidine - Loperamide is metabolized by Cyp3A4 and Cyp2C8 it is actively effluxed by PGP in the gut and brain. Quercetin blocks 40% of N-Demethyl. (2C8) and Ketoconazole blocks up to 90% (3A4)

Probably the most readily available inhibitor of Cyp3A4 and P-glycoprotein is Piperine in black pepper. This will only block 3A4 and PGP in the gut/liver and will not enable you to get high - though it may help with peripherally mediated opiate receptor withdrawal effects.

As for getting Loperamide across the BBB the best, easiest, and most readily available chemical is HP&#223;CD - HydroxyPropyl Beta CycloDextrin. Unlike coating nanoparticles and crap all you have to do with HP&#223;CD is mix in an aqueous solution and agitate for several hour/days(?). HP&#223;CD is mentioned along with loperamide in a few patents as being well suited for enhancing solubility & bioavailability. HP&#223;CD is reasonably readily available (alot of places that deal with both mind and muscle use it.)

Oh and insuffalating Stearate complexed loperamide is not very bioavailable, you'd need to break it down as detailed above, extract and adjust the pH back to normal. The nasal cavity has PGP, too although it takes a very low (hundreds of times lower conc.) of an inhibitor to block it here.

adder
22-05-2007, 11:21
Are you serious about snorting tablets? I'm serious about the question. Just threw up and there is no way I'm going to swallow it again. It's fucking hot here and I'm drinking water just to vomit it. Crazy. I would shove it up to my ass as good but I'm afraid the fountain of shit will follow shortly.

It better not taste like zolpidem, I might just throw up anyway...

Oh, fuck snorting pharms. Love it! Not a bad one after zolpidem anyway.

GOD, I don't think it was a good idea. You guys are crazy. It burns terribly. I spent last 10 minutes washing my nose and mouth from this shite throwing up a few more times. <thumbs up>

fuzzywuzzy123
23-05-2007, 10:52
what did you snort? Loperamide? Lomotil? ive snorted them both before and it wasnt that bad.