Metatron's Cube said:
WARNING!
I took 30 ultram's with about 4 tsp DXM cough syrup, 75mg benadryl, and 2 small cans of grapefruit juice. A few hours later I had a GRAND MAUL SEIZURE ...
Doubtful. Ultram/Tramadol is a kind of bastard child/frankenstein result of people dicking around with mixed agonist/antagonist/partial agonist opioids long before they really knew what they were doing. 30 of them could certainly cause a grand mal seizure in someone with the proper biochemistry -- let's all try not to forget that opioids ARE convulsants; I myself had a petit mal seizure when I started a course of wellbutrin and relapsed.
I don't know Tramadol's activity at the delta receptor, but if it's an antagonist there, you don't really need to worry about potentiating it; it won't form tolerance anyway. Actually, I think it's only a partial antagonist, which is why tolerance forms to Tramadol, but slowly. However, I'm not entirely sure.
I wouldn't blame the potentiators in this case, I'd blame the Tramadol. However, mixing benzos and opioids is never a good idea.
As I said in my lengthy post on page 3, taking benzos with opioids is not potentiation, it's synergism due to their combined depressant effects. You feel 'higher' with benzos and opioids for the same reason that you feel 'higher' with alcohol and benzos, or cocaine and amphetamines, etc.
When you take two separate classes of drugs at the same time that act on the same nervous system -- parasympathetic nervous system or sympathetic nervous system -- you will feel the effects exponentially rather than linearly. That is, 5mg oxycodone and 1mg clonazepam together will result in more depression than the net depression resulting from 5mg oxycodone taken a day before 1mg clonazepam.
Be careful. Potentiation and synergism are very different, and 90% of overdoses involve synergistic drugs (opioids and alcohol, benzos and alcohol, opioids and benzos, etc.).
Good luck; be safe.