Hi all,
This is probably a basic pharmacology question, but I was pondering about it, and wondered if anyone knew the answer.
Could someone explain how drug delivery method relates to the pharmacokinetics of a drug in the body? Specifically duration and elimination as a function of oral/nasal/injection/inhalation delivery systems.
Onset seems pretty straight forward, ie you hit your peak serum concentrations faster if you administer something IV versus orally where it would have to make its way through the digestive tract before being absorbed into the blood.
What I was wondering is how duration/elimination changes with delivery method. For example, time from 'peak high' (and I assume peak serum concentration) to baseline from smoking marijuana is drastically different than peak to baseline from ingesting it. Are there different elimination/catabolic pathways (and hence different half lives) for different delivery methods?
This trian of thought was prompted by http://www.awolmachine.com/ and their claims of "no alcohol hangover" due to their inhalation delivery method... afiak its getting burned into acetaldehyde either way, but would the alcohol intoxication duration/elimination paramters be any different?
This is probably a basic pharmacology question, but I was pondering about it, and wondered if anyone knew the answer.
Could someone explain how drug delivery method relates to the pharmacokinetics of a drug in the body? Specifically duration and elimination as a function of oral/nasal/injection/inhalation delivery systems.
Onset seems pretty straight forward, ie you hit your peak serum concentrations faster if you administer something IV versus orally where it would have to make its way through the digestive tract before being absorbed into the blood.
What I was wondering is how duration/elimination changes with delivery method. For example, time from 'peak high' (and I assume peak serum concentration) to baseline from smoking marijuana is drastically different than peak to baseline from ingesting it. Are there different elimination/catabolic pathways (and hence different half lives) for different delivery methods?
This trian of thought was prompted by http://www.awolmachine.com/ and their claims of "no alcohol hangover" due to their inhalation delivery method... afiak its getting burned into acetaldehyde either way, but would the alcohol intoxication duration/elimination paramters be any different?