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Dope_User
15-11-2004, 00:46
As far as I know, exercise, sex, and even drinking water (can't find the source where I found that about the water) as help raise endorphin levels or production of endurins.

It's my understanding that PART of opiate withdrawal symptoms are due to low levels of endorphins. While other drugs are often used to treat symptoms of withdrawal, it's my hypothesis that attempting to raise endorphin levels naturally could provide significant, or at least some, benefits by reducing withdrawal symptoms. So, what other activities can raise endorphin levels? How helpful do you think these natural ways of raising endorphin levels would be at alleviate some of opiate withdrawal symptoms?

Also, what is actually going on in the brain/body that causes these symptoms? Is there a lack of certain neurotransmitters? I think I heard there are low levels of dopamine during opiate withdrawal so could taking an SDRI (i.e. Wellbutrin) help with symptoms as well? Are there vitamin or mineral defiencies that cause symptoms (that could be at least partially alleviated) by replacing those vitamins/minerals through supplements or better eating habits?

What other chemical changes are going on in the brain/body that lead to withdrawal symptoms? Are there any drugs or natural ways of "returning these chemical levels to normal" that would help with withdrawal symptoms?

Basically, I'm looking for a way to treat the actual cause of withdrawal and not just treating the symptoms (by taking meds such as Imodium, NSAIDS, benzos, sleeping pills, etc.). Any thoughts and have I made any correct assumptions here?

BilZ0r
15-11-2004, 06:32
You can't treat withdrawals with opiates... all that will do is lengthen the withdrawals, and I've allready told you, withdrawal probably isn't mediated by low endogenous opioids.

Treating the symptomes is the best way, you can't agonise the opioid receptors. Potentially if you could find a way to upregulate opioid receptors that could work.

PhorIndicator
15-11-2004, 08:17
Why would exercise not work to assist withdrawals? Also, im still waiting for an answer to my DLPA thread, which (on the DLPA bottle claims to extend the release of endorphins in the body). Would postloading DLPA assist in WDs?

BilZ0r
15-11-2004, 11:35
Exercise very well might work.

I'm sure your DLPA claims that, If I was a billionare I spend all of my money sueing the supplement industry for blatant false advertising. There is no proof that DLPA in vivo, at reasonable doses, potentiates endorphin (or enkephalins).

Diarrhea
03-12-2004, 19:51
sorry to bring up an old thread (i'm new, don't hurt me :]) but no one mentioned this: Accupuncture. western medicine hardly acknowledges the great potentials of meridan stimulation, mainly because it'd put a lot of drug companies out if it was widely received, but what is acknowledged in western medicine is it's ability to relieve pain. it increases endorphin levels greatly, even producing a euphoria. i'm pretty sure i've seen it being used for drug addiction, but i'm not sure.

Keret
03-12-2004, 20:35
I've also heard of a technique where they use electric current with extremely low intensity but very high frequency. Apparently this technique stimulates the release of endorphins and is apparently used in some centers for withdrawals but i'm not sure this is the kind of stuff that you were asking for...

Diarrhea
04-12-2004, 04:12
it is in a way, because those electric currents effect the same meridan system that accupuncture does (further proving it works). also, meridans can be stimulated by tapping them with your fingers. i can relieve my headaches instantly by tapping a few places on my face. if you want to know more about this stuff, PM me and i will show you how to do it yourself, i'm sure it would help with withdrawal.

PhorIndicator
04-12-2004, 07:14
DXM?

Diarrhea
05-12-2004, 01:04
what about it? i wouldn't recommend it for opiate withdrawal if that's what you're suggesting.

PhorIndicator
05-12-2004, 01:46
clonidine (catapres)

Dope_User
05-12-2004, 04:54
PhorIndicator, please provide some type of evidence with your posts. As for DXM, it seems debatable at best as to whether or not it helps anyone with W/Ds...as for raising endorphin levels, I've NEVER heard of that

Almost the same goes for clonodine; I've never heard of it boosting endorphin production although it has been used with some effectiveness in easing W/Ds. I have personal experience with this when withdrawing from a relatively small (small compared to some on this forum any way) heroin addiction. It worked quite well for me, but again this wasn't a huge addiction. But as I said, I've never seen evidence that either of these have anything to do with raising endorphin levels...if you reread the initial post, it was really about trying to treat the cause of withdrawal, and not merely treating the symptoms.

I still don't understand (and haven't gotten any replies) about what is actually going on that causes withdrawals. BilZ0r did mention that "if you could find a way to upregulate opioid receptors that could work."

If you reread the third and fourth paragraphs of my initial post, that is what I'm now looking for answers for (as BilZ0r debunked my endorphin hypothesis...which I appreciate; I wasn't trying to be right, just trying to understand).

BilZ0r
05-12-2004, 08:37
Yeah, clonedine is all about reducing withdrawal symptomes, but doesn't really treat the cause.

When it comes to accupuncture, sure so called "western medicine" ignored it for a while, but now, all but the most back-woods doctors know it has power... when it comes to electrical high frequency stimulation... I know there is one paper on the subject, which looked at PLASMA beta-endorphin LIKE material, but it was published in a completely unknown journal, and as I've mentioned before, plasma endorphin levels have no bearing on anything.

tcluna
06-12-2004, 00:00
low dose naltrexone does this

Chuff
31-12-2004, 15:36
accupuncture is used widely in the Uk to help treat clucks, I have heard a full body body accupuncture session compared to the equilivent of 30mls of methadone and personally seen hundreds of people reduce cravings and related symptoms with auricular acupuncture.

massage and other alternate therapies are recognised in the Uk as very benificial for people wishing to change substance use behaviour.

I am really rather interested in the use of hypnotherapy for this haveing seen clients access states of euphoria and extreme relaxation during hypnotherapy and would love to see some research into chemical changes in the brain during all forms of treatment, espically permenant chemical changes induced by trance states instead of the same old shit 'addiction can be proven chemically' that the pharm companies churn out to justify $$ on research into agonists and antagonists for 'addicitve' substances.

lets look instead at how changes in brain chemistry occur in people who overcome addiction (espically wiht alternate therapies) and how we can teach people to manage this sort of chemical change not only naturally but without external assistance......


oh no theres no money or political agenda for that:X

prime3end
04-10-2009, 22:37
Meditation 20 minutes , twice a day , is a way to produce massive increases in about 2 weeks to a month. It would require a group setting for most addicts, but if you just want to do it to increase the number and activity of your immune cells it's a great way to do it.

Naltrexone used in high doses is used in alcohol and drug addictions cases,but at a very low dose at bedtime, about 3.75 to 4 mg causes a big increase in endorphins by morning. I don't know how this would work out in addicted people as far as a dosage meant to increase endorphins vs the dosage and purpose of the higher dosage used in addiction. Someone else will have to speculate on that.

This fits nicely with Blackburn's work on stressed caregivers, caring for their very very sick children and family members. Each caregiver was polled on the level of stress they had for the week, a subjective evaluation of course, but it correlated very well with the concurrent blood testing. The blood tests measured the number of T-cells, and their activity, and measured their telomere lengths. The world now understands the mechanism by which emotional stress actually kills T-Cells, reduces their lifespan, and their level of activity. The corporations will never like this, LOL,, but it is a proper indictment of living a stressed out rat race life, or having an overactive never resting emotional state.

I want to stress the importance of a rigid schedule for the meditation, mandatory group settings are best. I'd guess it's a fine way to cut health costs in the general population and in jails too. Prayer would probably work the same way, as long as the twice a day for 20 minute threshold is met.

Healthy Regards,

Prime

prime3end
04-10-2009, 22:40
And you could add excercise instead of inactivity, and the laughter sessions, good comedy movies and sound tracks. Personally I have only achieved noticeable endorphine increases from exercise when I pushed myself to the level of getting that second wind. Of course falling in love has the same effect but isn't something that pills can easily achieve. Viagra is a start but it needs a love potion too for optimal endorphine production :-)

chloral hydrate
05-10-2009, 01:02
I remember in school we used to run 1.5 miles every thursday, and I was one of the top runners even I'm generally pretty large and slow. But I would try really hard to stay in front and run the whole way without stopping (for real runners 1.5 miles is a joke), just staying consistent while some people tried to sprint and stop, sprint and stop. And then at the last 100 meters I'd just sprint like hell running faster than anyone else had sprinted.

One time at this last 100 meter runway, there was only one person in front of me, in front of me by 6 or 7 seconds and it was a sure win for him. But I sprinted (ran on my toes) really fast and you'd never imagine what happened. Those 100 or 150 meters or so I just completely disconnected from my body. It was like a giant adrenaline rush/endorphin nod combined. I could see my legs moving but I didn't even feel them, I should remind that I was still "winded" from being out of breath running but I didn't feel that either. It felt like a massive endorphin released and it was making me nod. I couldn't feel anything. It was very euphoric, not a dopamine like euphoric, but just like opiates stronger than I have ever felt. But that was only for about like 10 seconds until my sprint beat the guy in front of me and I came in first, 9 minutes flat.

Anyways if you want to have some massive opiate releases, try running. I find the best is when you try to run some distance completely not stopping to walk at all. Stop once and it's over. From what I read, when it is really hard to breath (i.e. you are winded) that's when you get lots of endorphins released, not from general excercise or mild jogging, although those still increase your dopamine levels. Tell me when you get a nod stronger than any morphine I ever felt from "meditation" or "sex" or "weightlifting".

negrogesic
05-10-2009, 01:47
I hope you guys realize this thread is 5 years old...

chloral hydrate
05-10-2009, 03:03
The reason you get tolerant to opiates is because the endorphin receptors desensitize right? They should really work on the beta-arrestin enzyme inhibitors or whatever, then people would be able to never become tolerant or go through withdrawal. PMID: 16750901 (http://www.ncbi.nlm.nih.gov/pubmed/16750901)

As for the taking naltrexone before bedtime, I think that would work albeit it would probably be unpleasant. For example you'd be restless and not fall asleep or wake up during the night. This does explain though for example why people can take medications like amphetamines years after years without losing effectiveness. Because they're still taking the medications during the day, while being off them at night.

chloral hydrate
07-10-2009, 08:17
Something else of interest on those b-arrestins or whatever:


Unlike most μ-opioid agonists, herkinorin does not promote the recruitment of β-arrestin-2 to the intracellular domain of the μ-opioid receptor, or induce receptor internalisation.[6] This means that herkinorin may not produce tolerance and dependence in the same way as other opioids, although some development of tolerance through other mechanisms has been observed,[7] and some other analogues related to herkinorin can recruit β-arrestins.[8]

fastandbulbous
07-10-2009, 11:50
Eating chilli - simple and pleasureable (it's one of the reasons hot Mexican/Indian etc food leaves a person feeling quite satisfied & content). Not sure how it's help w/d, but it does work

enzymex
07-10-2009, 16:38
Eating chilli - simple and pleasureable (it's one of the reasons hot Mexican/Indian etc food leaves a person feeling quite satisfied & content). Not sure how it's help w/d, but it does work

Snorted capsaicin or strong chili powder will give pretty intense endorphin rush, comparable to runners high. Should work for migraine too. There's some capsaicin nasal sprays, at least in the US market, that are marketed for migraine.

Might burn pretty hard initially, but could be of some help during opiate WD's.

negrogesic
07-10-2009, 20:20
I've been sprayed with pepper spray and at no point is it enjoyable (sprayed myself, not rape related)...

ebola?
07-10-2009, 22:29
Snorted capsaicin

MY GOD. :)

ebola

irobeth
07-10-2009, 22:46
Snorted capsaicin


MY GOD. :)

ebola
^
Nothing about this sounds fun. Capsaicin isn't water soluble either so it'd just sit up there burning you to hell and back.

enzymex
07-10-2009, 22:47
http://www.health-informant.com/articles.php?articleId=616

El Cubano Poco
08-10-2009, 01:09
2nded on the Capsaiscan, snorting a lil bit with water is the fasted way to relieve pain from a headache/migraine.

If your hardcore you will DO IT! :D

Seriously, it's awsome...after the burn that is

The Hebrew Hammer
08-10-2009, 09:07
nothing natural about snorting capsaiscan...

Other than DEBILITATING PAIN of course!!!

(sorry, I was kind of zoned out from sleep deprivation and read lots of the threads and when i realised the title and substance of this thread towards the most recent posts I couldnt resist the pun.... now i think ill try to get some sleep)

fastandbulbous
09-10-2009, 06:00
From the article enzymex provided a link to

But what about the burn -- can you hurt yourself with hot peppers? Definitely not, according to the United States Dispensatory

What!? If you inhale capsacin soln that has been atomized into a spray you could have an asthma attack (mts f&b gets breathing difficulties & has to use her inhaler when I've put items that have been used with chilli oleoresin into the washing up and hot water is run onto them).

A bit OT, but if you have problems sleeping, forget sedative antihistamines etc, just make a toasted cheese sandwich with lots of fairly hot chilli & with the endorphin release after you've eaten it, it's much easier to drift off to sleep (and no zombie hangover like you get with Nytol & other sed. antihistamines) - well after about 5 minutes when the initial burn has subsided! =D

willow11
09-10-2009, 06:22
From the article enzymex provided a link to


What!? If you inhale capsacin soln that has been atomized into a spray you could have an asthma attack (mts f&b gets breathing difficulties & has to use her inhaler when I've put items that have been used with chilli oleoresin into the washing up and hot water is run onto them).

A bit OT, but if you have problems sleeping, forget sedative antihistamines etc, just make a toasted cheese sandwich with lots of fairly hot chilli & with the endorphin release after you've eaten it, it's much easier to drift off to sleep (and no zombie hangover like you get with Nytol & other sed. antihistamines) - well after about 5 minutes when the initial burn has subsided! =D

This interests me. Are you taking the hottest peppers you can find?

fastandbulbous
09-10-2009, 16:06
NO! Naga chillies are on a par with nuclear waste/Kryptonite 8o =D

Just using bog standard chillies, but putting a generous amount on top of the cheese before folding over/squashing together. If you're a chilli devotee, you might want to use Bird's Eye or habaneros chillies for an extra boost, but don't mess with naga chillies - it'll end in tears!

B9
09-10-2009, 21:16
^ Pfft lightweight!

daddysgone
10-10-2009, 00:09
Seeing as how this ancient thread has gone way off-topic anyhow, I thought Id just throw in a bit of random chili trivia which I find fascinating.

It has recently been discovered that tarantula venom activates the same pathway of pain as is activated by capsaicin, the first demonstrated case of such a shared pathway in both plant and animal anti-mammal defense.

Pretty cool stuff, huh?

vecktor
10-10-2009, 00:10
NO! Naga chillies are on a par with nuclear waste/Kryptonite 8o =D

Just using bog standard chillies, but putting a generous amount on top of the cheese before folding over/squashing together. If you're a chilli devotee, you might want to use Bird's Eye or habaneros chillies for an extra boost, but don't mess with naga chillies - it'll end in tears!

get mexicana cheese, it is presynthesised chilli cheese and splendid.
screw all that messing about with chillies, washing hands super well before going to the toilet as well as after...

more chili trivia, different chillis contain different capsaicin like compounds with different effects capsaicin itself is responsable for the burning general hotness in the back of the mouth and nose, like CS gas, and others are give quite different hotness, hotness on the front of the tongue or general flavour intensity.
and capsaicin like compounds hook in nicely with cannabinoids, a lot of endocannabinoids also interact with trpv-1 as does capsaicin.

ebola?
10-10-2009, 03:19
get mexicana cheese, it is presynthesised chilli cheese and splendid.

Is this what they call pepper-jack in Britain? Is that what chemists use instead of the verb, "to combine"? ;)

madsci
15-10-2009, 20:38
wouldnt reccommend it. Electrical impulses stimulate neuronal growth in certain parts of the brain esp. the frontal lobe. Since your receptors are already pretty messed up by the opiates the neuronal growth wont be directed properly

madsci
15-10-2009, 20:41
Eating chilli works on your caspacin receptors, same as those that precieve stimuli in the form of heat.
Could be on to something there but it would rather be diverting your brains attention to something other than the withdrawal symptoms by stimulating a different sensory receptor system than dampening them.

chloral hydrate
16-10-2009, 09:19
I got a truly horrid idea just now. What if you were to inject capsaicin? Better yet acetylate that -OH so it can cross the blood brain barrier before causing horrible pain at all the pain receptors. I bet it would get those endorphins going though.

Or another idea: wrap some aluminum foil around your head and get a blowtorch. Now don't let the flame get too close or the foil will burn. Just keep flame far enough to keep those endorphins flowing in your head.

dread
17-10-2009, 14:42
What if you were to inject substance P?

ebola?
17-10-2009, 20:28
I'd stick to Substance D, and also exorphins, in this case. ;)

seep
14-11-2009, 03:34
A bit OT, but if you have problems sleeping, forget sedative antihistamines etc, just make a toasted cheese sandwich with lots of fairly hot chilli & with the endorphin release after you've eaten it, it's much easier to drift off to sleep (and no zombie hangover like you get with Nytol & other sed. antihistamines) - well after about 5 minutes when the initial burn has subsided! =D

I've gone through like 4 lbs of serrano peppers since I read this. I love the feeling. They stop burning the tongue so badly after a few days.


ed: This is has got to be a record. (http://en.wikipedia.org/w/index.php?title=Serrano_pepper&oldid=233001040)

dogfood
14-11-2009, 03:42
I got a truly horrid idea just now. What if you were to inject capsaicin? Better yet acetylate that -OH so it can cross the blood brain barrier before causing horrible pain at all the pain receptors. I bet it would get those endorphins going though.

Or another idea: wrap some aluminum foil around your head and get a blowtorch. Now don't let the flame get too close or the foil will burn. Just keep flame far enough to keep those endorphins flowing in your head.

your brain doesn't have any pain receptors so it would just make your veins burn like hell...

alec_empire
30-11-2009, 22:57
I think the most effective way to release endogenous opioids is vigorous exercise and social engagement with family and friends.

Unfortunately, some people do have dysfunctional endogenous opioid systems which is associated with diminished endorphin/ enkephalin / endomorphin - release ( can be seen with PET scans, where there is a secondary up-regulation of mu receptors du to decreased occupancy by endogenous opioid peptides )


See:

http://www.nature.com/nm/journal/v2/n11/abs/nm1196-1225.html




http://bjp.rcpsych.org/cgi/content/full/191/1/63

seep
02-01-2010, 07:35
Metformin!

OK it's not entirely natural, but it kickstarts a natural mechanism that slows down with sedentary behavior. I've been coming off amphetamine since right b4 Xmas, so I've been otiose. For the past 3 days I've been taking metformin 500 mg bid and it's had me feeling like--well imagine what pediatric heroin would feel like.

I found this ipso facto:


1. Horm Metab Res. 2006 Feb;38(2):106-11.

Metformin increases insulin sensitivity and plasma beta-endorphin in human
subjects.

Ou HY, Cheng JT, Yu EH, Wu TJ.

The Division of Endocrinology and Metabolism, Department of Internal Medicine,
Institute of Clinical Medicine, College of Medicine, Tainan, Taiwan.

Metformin has been widely used in clinical type 2 diabetes treatment and
prevention. The present study was designed to explore the effect on people with a
sedentary lifestyle at therapeutic doses. Twenty-two physically-inactive
volunteers with normal glucose tolerance were studied. Escalating doses of
metformin in low-dose (250 mg), intermediate-dose (500 mg), and high-dose (750
mg) treatment three times per day were administrated into each subject for a
three-week treatment period. Fasting plasma glucose, A1C, HOMA-IR for insulin
resistance, lipid profile, and plasma beta-endorphin-like immunoreactivity (BER)
were measured before treatment and weekly at the end of each dosing period.
Metformin significantly reduced fasting plasma glucose and HOMA-IR in healthy
humans after receiving this treatment at therapeutic doses including low-dose (5
%, 17 %), intermediate-dose (6 %, 25 %) and high-dose treatment (6 %, 21 %).
Plasma BER was also increased from 135.46 +/- 61.73 pg/ml to 137.52 +/- 66.11
pg/ml by low-dosing (p = 0.39), to 139.17 +/- 64.08 pg/ml by intermediate-dosing
(p = 0.32), and to 149.59 +/- 63.32 pg/ml by high-dosing (p < 0.05). Also, serum
cholesterol decreased significantly using metformin at therapeutic doses
including low-dose (4 %), intermediate-dose (8 %) and high-dose treatment (7 %).
However, metformin failed to modify levels of serum HDL-cholesterol and
C-reactive protein (CRP) in healthy subjects. Also, the reduction of serum
cholesterol by metformin did not correlate to the increase in insulin
sensitivity. In conclusion, metformin causes a significant parallel increase in
insulin sensitivity and plasma beta-endorphin level in human subjects.

PMID: 16523411 [PubMed - indexed for MEDLINE]

This possibly is why:


1. Diabetes. 2006 Mar;55(3):819-25.

Novel mechanism for plasma glucose-lowering action of metformin in
streptozotocin-induced diabetic rats.

Cheng JT, Huang CC, Liu IM, Tzeng TF, Chang CJ.

Department of Pharmacology, College of Medicine, National Cheng Kung University,
Tainan City, Taiwan 70101, ROC. jtcheng@mail.ncku.edu.tw

To better understand the insulin-independent plasma glucose-lowering action of
metformin, we used streptozotocin (STZ)-induced diabetic rats to investigate the
possible mechanisms. Oral intake of metformin decreased the plasma glucose of
STZ-induced diabetic rats with a parallel increase of plasma beta-endorphin-like
immunoreactivity (BER). Mediation of opioid mu-receptors in the action of
metformin was identified by the blockade of receptors with antagonist in
STZ-induced diabetic rats and the failure of action in opioid mu-receptor
knockout diabetic mice. Release of BER from adrenal glands by metformin was
characterized, using bilateral adrenalectomy and the release of BER from isolated
adrenal medulla of STZ-induced diabetic rats. Repeated treatment with metformin
in STZ-induced diabetic rats increased the mRNA and protein levels of GLUT-4 in
soleus muscle that was blocked by naloxonazine. Reduction of the mRNA or protein
levels of hepatic PEPCK was also impeded in the same group of STZ-induced
diabetic rats. In conclusion, our results provide novel mechanisms for the plasma
glucose-lowering action of metformin, via an increase of beta-endorphin secretion
from adrenal glands to stimulate opioid mu-receptor linkage, leading to an
increase of GLUT-4 gene expression and an attenuation of hepatic PEPCK gene
expression in STZ-induced diabetic rats.

PMID: 16505249 [PubMed - indexed for MEDLINE]

Crendore
31-08-2011, 16:10
Endorphins are Endogenous Morphine which is your bodies own version of morphine and you always have a certain level of endorphin's at any time. when you take opiates you make the body think that it no longer needs to produce endorphins because it is getting it from an outside source. so the body slowly produces less endorphins until you get to the point where your body wont produce any and you need morphine to produce it for you. The withdrawal is the body having no endorphins at all and this causes the symptoms of nausea, dizziness, vomiting, misery, etc because you are effectively putting yourself through the polar opposite of an opiate high. One thing I would be interested to find out is that is the speed of ingesting and excretion affect the likelihood of addiction as with cocaine, which is very similar to Methylphenidate and because it works so quickly and disappears so quickly this makes the body miss the drug where as methylphenidate enters and leaves more gently creating less likelihood of addiction occuring. I think it would be worth eating or drinking opiates in the future as opposed to injecting or smoking them as this could perhaps lessen the likelihood of addiction and make for a more mellow and gentle high.

pema
14-03-2012, 17:09
It's an old topic but still interessting. So I will add something to that.
BTW: The original question was never answered.

The following text shall be a citation from the strange book "End your addiction now":

In 1972, scientists at the Johns Hopkins University School of Medicine discovered that the human brain produces chemicals that closely resemble morphine, the powerful painkiller. They named these newly discovered substances endorphins. Studies with laboratory animals found that the endorphins were incredibly effective. An endorphin called beta-endorphin was 18 to 50 times stronger than morphine. And dynorphin was apparently 500 times more powerful!
The German wikipedia states that is was 1975 (three years later) and that they found in in pigs and not humans.

When this is true that those stuff is so powerful and better than morphine - why isn't it used as painkiller for humans? Probably it won't have may side effects because it's natural to your body. I was unable to find something on the pai killing potency of endorphines.
German wikipedia writes that from hypophysis in blood stream released beta-endorphine binds to opioid receptors but would not produce analgesia there.

For me it looks like if the enkephalins were responsible for pain reduction and not endorphines. But I am no doctor.

This "End you addiction" cite goes on:

Fortunately, a way to protect the endorphins was quickly discovered. The substance was a simple nutritional amino acid called dl-phenylalanine (DLPA). DLPA is not a drug. It does not block pain. DLPA protects the endorphins from the endorphin-eaters, helping to restore the body's ability to deal with pain. Phenylalanine is found in fish, chicken, eggs and other foods.

Studies have shown that DLPA effectively blocks arthritis pain and joint inflammation in many patients. It is much safer than the standard arthritis medications and considerably less expensive in the long run. Best of all, it is long-lasting. Whereas standard anti-pain and anti-arthritis drugs last for several hours, DLPA can continue quelling pain for up to four or five days.
Actually DLPA is said to be an enkephalinase inhibitor. That would prevent the breakdown of enkephalines and not endorphines.
But I think, it could be a possible help during withdrawal. I haven't tried it but it sounds logical. When DLPA can inhibit enkephalinase then this enzyme cannot break down the enkephalines.

Before thinking how to raise endorphine levels, it would be interessting to know is this has any postive effect on opiate withdrawal or whatever.
Maybe it's the enkephalines to should be raised.
I never saw any studies what the effects of increased endorphine or enkephaline levels are. It seems that science is still unsure what the exact jobs of endorphines are. Some years ago, it seemed clear, that endorphines are responsible for feelings of luck and pain reduction but now it seems as science is unsure about that.

You will feel better during opiate withdrawal when you go for a walk or do some exercise. But are endorphines really responsible for that?
Maybe it helps to boost all endogenous opioid levels..?
And has anyone tried DLPA? Did it help during acute withdrawal or PAWS?

Enix150
18-03-2012, 12:15
^ Some very interesting points to consider! It seems I have more reading to do... I would assume dynorphins aren't used medicinally because of the possibly massive side-effect profile? They play with appetite, depression, pain, and so many things; the system doesn't seem to be well enough understood yet..

Hey just wanted to a share a strange and probably not useful story! So the other day I took a spill and tumbled pretty hard into the ground. (It's actually quite surprising how thoroughly I managed to wreck myself considering I was on level ground..) Somehow I managed to smash my knew and roll around to break my hand too somehow... Anyway, I got really really pale, threw up, and had to resist the urge to fall asleep: all standard shock-reactions. I staggered back to my place all covered in blood, just wanting water more than anything. when I finally got there my heart had calmed down a little bit the nausea had subsided and I wasn't so pale, but when I sat down to smoke and explain my mess of a self, I noticed the room start to darken as if I had eaten an opiate. At first I thought this was the shock coming back or a trick of the light, but sure enough, the pain started going away and within a few minutes I was fully faded! (voice changed and everything) I had heard about injuries (especially when you sustain multiple of them) causing the release of endogenous opioid peptides, but never had I felt(noticed?) the effects so strongly!! It only lasted an hour or two, but it certainly took me by surprise.

atrollappears
18-03-2012, 19:17
For me it looks like if the enkephalins were responsible for pain reduction and not endorphines. But I am no doctor.

I think it's that endorphins (being massive molecules) do not cross the blood brain barrier, and opiates act as central analgesics. So, only endorphin released in the brain would have analgesic effects.

pema
09-04-2012, 17:48
Raising natural endorphin levels with hot peppers

It is said that hot spices, especially eating chili peppers, shall be able to increase endorphin levels.

It is asserted by many that prolonged stimulation from capsaicin releases B-endorphins from the brain to impede and reduce pain. It is based on this idea that capsaicin has been used as a medication to aid in the alleviation of many chronic disorders, such as rheumatoid arthritis, and viral and diabetic nerve damage. However, much like a chili-eaters tolerance increases with the frequency of their use, extended use of this chemical leads to desensitization and therefore a higher dose is needed to be effective.

But is it necessary that we eat those chili peppers?
I often read that capsaicin and the burning sensation leads to substance p release and pain which increases endorphin levels.
But I saw that there are chili capsules which are sold to increase endorphin levels and to lower pain. Does this really work?
I don't feel the burning sensation when I swallow a chilli capsule. Then I don't realize that it is hot.
Do those chilli capsules/capsaicine capsules/cayenne capsules really increase endorphin levels like the vendors' websites tell it?
Or will only eating hot peppers do this job?

endotropic
09-04-2012, 21:24
Endorphins/enkephalins/dynophins aren't used therapeutically because they are peptides and would be broken down by proteases before they could reach the brain, unless you were to IV ridiculous amounts or inject them straight into your nucleus accumbens or something.