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View Full Version : Baclofen....does anyone know what this is?



Dependence03
05-11-2004, 03:20
My doctor has had me on a high dose of neurontin for some time, but it does NOTHING for my anxiety. I beg him to put me on a benzodiazepine, but he refuses. My life is unmanageable with my anxiety/panic. He just wrote me a script for Baclofen, and says it might help. I can't find much information on this stuff at all. Does anyone knows anything about Baclofen?! Its supposedly a GABA-B agonist.

BilZ0r
05-11-2004, 04:00
Yup, it is definatly a GABA-B agonist... It might possibley have some effects. My advice, get a new doctor... he could at least prescribe something which is indicated for anxiety.
If he's not going to put your on a benzo, you coudl ask for an SSRI or buspirone.

nenarOPI
05-11-2004, 04:36
my dad had it prescribed for back aches/pain/tension. they didnt help. i've taken them..no good recreational effects

K'dOUTinAZ
05-11-2004, 05:59
Drugs that affect the GABA-B receptors shouldn't be recreational but might help with anxiety but not all that much. Drugs that affect the GABA-A receptors are typically recreational and work much better for anxiety. I believe that Neurontin is supposed to affect the GABA-B receptors also. I'm suprised that he prescribed you this drug because Baclofen is nothing more than a muscle relaxor and anti-spastic. It shouldn't really calm you down as much as just make you a little drowsy. From what I have read it lasts anywhere from four to eight hours and takes about one hour to kick in. When all is said and done, Baclofen is not a recreational drug and isn't really prescribed for anxiety. Why does he refuse a benzodiazepine? Does he think that your anxiety is bad enough or is he aware of any sort of current or past drug abuse? I would recommend that you go see another doctor or at the very least ask for some sort of SSRI like Paxil or an SNRI like Effexor, both which are prescribed for both anxiety and depression. Hey, its better than the drug that you are prescribed right now :\

nagash
10-12-2004, 20:01
Actually, especially for an alcoholic, GHB addict or the like, baclofen feels nice.

Riemann Zeta
11-12-2004, 04:47
Is GHB actually a GABA-B receptor full agonist? A few years ago, I heard rumours of a specific "GHB receptor," but I never saw any follow-up research that would disambiguate the GABA-B receptor and the magical GHB receptor.

K'dOUTinAZ
11-12-2004, 05:06
Gamma-hydroxybutyrate (GHB) is a naturally occuring metabolite of GABA that acts at GHB-specific, G protein-coupled presynaptic receptors. GHB is also a weak partial agonist at GABA-B receptors. The effect of GHB on regional and subcellular brain adenylyl cyclase in adult and developing rats was determined and compared with that of the GABABR agonist (-)-baclofen.

And a shit load of info on GHB:

http://www.blackwell-synergy.com/links/doi/10.1046/j.1471-4159.2000.0751986.x/full/

And another one

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=10587082&dopt=Abstract

BilZ0r
11-12-2004, 06:06
High doses of GHB = GABA-B, low doses = GHB-receptor.

http://www.erowid.org/chemicals/ghb/ghb_pharmacology1.shtml

The GHB receptor is something that has been seriously ignored... I'm totally keen to get in and do some research on that.

marxspeakstruth
13-12-2004, 06:47
fuck SSRIs, they dont do shit. it wasnt untill my doc put me on welbutrin that anything changed

nagash
01-03-2005, 22:56
In case someone wanted to know. After taking seroxat I developed serious extrapyramidal symptons, like muscle aches, tremors and such. I were worsening the effects by drinking alcohol to actually get some rest for a couple hours. I then switched to tetrazepam which, for a benzodiazepine, has no mind numbing effects.
Then I switched to very high doses of baclofen, which, for the first days, worked wonders. I was sublty taken to the pleasant GHB-like feeling high, with all the sexuality, disinhibition, euphoria and the like. After a couple days the effects are still there, with increased sexuality, much less tension, definitely socialising properties. The only downside is a possibility, higher than with GHB, to fall into asleep in a very narcoleptic pattern.

It is also worth noting that baclofen is a chloroderivative of phenibut, which is said to be a fine GHB replacement. I, however, find baclofen way cleaner and less toxic than phenibut, as phenibut is active in the 2-3g range whereas 150mg baclofen is already lots of fun.

PurrrinInOk
01-03-2005, 23:47
I missssss GHB/GBL....very fun times on that stuff!!
It's pretty much non-existant now though, at least in my state. *pout*

psychetool
02-03-2005, 13:59
time to get a new docter

Lojiko
31-05-2009, 16:53
Nagash ... 150mg of baclofen sounds like a lot! How do you get a doc to write a scrip for that much? Last I heard, around 10mg 3 times dailt was a typical doseage.

QuasiStoned
31-05-2009, 20:15
This thread was started over 5 years ago and hasnt seen any discussion in 4 years. I doubt that the OP is here to reply to you...

PharmTech09
01-06-2009, 18:48
I was on Baclofen for my back and it did not help, even a little bit. I took 100mg at a time (ten pills) 3 times on one day and still had no relief. It is available in 10mg tablets and 20mg ODT's. In my opinion, it is a useless drug for back pain and it was useless for anxiety as well.

tom quinn
13-09-2009, 03:08
Baclofen is the best drug I have ever taken! I have felt like I am on "Valium" but better.

It makes me feel like normal again and relaxes me better than Valium.

I am not anxious but "tense" and guess what "Baclofen" works the best!!

I am not tense anymore?

Tommy

Drench
29-09-2009, 20:33
I find Baclofen stronger than Phenibut. I get GHB/GBL like euphoria, talkativity, hornyness etc just not quite as strong, it feels a lot cleaner than G though.

Shambles
29-09-2009, 20:35
I was on Baclofen for my back and it did not help, even a little bit. I took 100mg at a time (ten pills) 3 times on one day and still had no relief. It is available in 10mg tablets and 20mg ODT's. In my opinion, it is a useless drug for back pain and it was useless for anxiety as well.

This is exactly my experience with Baclofen. Was also prescribed it for back pain and it did precisely shit all :\

maximumstrength
07-10-2009, 15:42
I find baclofen to be recreational. In took 85mg and felt like I was floating while laying on the couch. then after about an an hour and a hafl I started getting blurry vision and started to doze off. A few hours later my mom found me and she said she had to smack me in the face just to wake me up. side note I am also on ( 4mg of suboxone, 2mg of xanax, 50mg prozac, 6mg zyprexa, 40mg ritalin, and 10mg ambien) but I had not taken my xanax or ambien when I tried baclofen.

bkuyk369
09-10-2009, 19:25
SWIM is on 12 mg's of suboxone daily and was prescribed one hundred and twenty 10 mg baclofen. The first two times SWIM took around 70mg's but didn't really know what to think about it, just felt weird and out of it and very clumsy and tired the next day. SWIM waited about a week to try this again because of all the positive and recreational effects SWIM's read about, and this time felt absolutely amazing. Very euphoric and SWIM has never tried GHB but could imagine it's very similar. SWIM had alot of energy and was very motivated. Also would doze off randomly and then randomly would have bursts of euphoric energy.. Absolutely had no anxiety and SWIM would think it's like a mix of Valium and GHB. Definitely euphoric and really looking forward to doing again. SWIM has also noticed that a dose of 60 mg's works perfect everytime and no tolerance has set in. This is also my very first post on bluelight so I apogize if this carried on too much or if I broke any bluelight rules.

PitheGreek
04-12-2009, 00:41
What do you think is a good dose of baclofen for a mild anxyolytic, euphoric effect?

Drench
09-12-2009, 15:50
20-40mg once or twice a day takes away my worries and replaces them with happiness, also gives me motivation.

bkuyk369
14-01-2010, 04:11
ya i would say at least 40mg's to take away anxiey, and up to 80mg to really feel the good effects

Violenza666
14-01-2010, 04:21
Get a new Dr. I was at a point where I could barely function due to anxiety and panic attacks. My dr looks at Benzodiazepines for somebody with anxiety/panic disorders as insulin for a diabetic. He is a specialist in treating panic disorder patients and he is also a published author on the subject. I moved here went to a dr and had a hard time getting a dr to re prescribe my xanax he called me a junkie and wanted me to quit cold turkey.. luckily I found the dr I have now.

The first dr who gave me my xanax I basically told him I did not want to be medicated on anti depressants. That I wanted something that would be in and out of my system and to take as needed. He gave me as much Xanax as I felt I needed. I was always completely honest with him about how much I was taking and he was fine with it. Then I moved here and am now seeing the specialist. My advice is to find a new dr and soon.

psychihelp
14-09-2010, 20:27
My doctor has had me on a high dose of neurontin for some time, but it does NOTHING for my anxiety. I beg him to put me on a benzodiazepine, but he refuses. My life is unmanageable with my anxiety/panic. He just wrote me a script for Baclofen, and says it might help. I can't find much information on this stuff at all. Does anyone knows anything about Baclofen?! Its supposedly a GABA-B agonist.


Hi , I'm a neuropsych meself, doesn't mean I don enjoy pot, or never tried heroin , but I now mostly enjoy pharma cocktails:D lets talk of baclofen
Try Baclofen if u wanna feel good , its a GABA-B selective agonist - that'll relax muscle spasms due to injury, but gaba-b agonism DISINHIBITS AND SLOWLY SPEEDS UP DOPAMINERGIC transmission in pleasure centres of the brain. also seroternergic neurotransmission speeds up via indirect action on 5HT1A receptors and a happy relaxed state arises the higher u dose. BUT PLEASE DON GO ABOVE 75-100 mg and that's all this doctor can remember from the fat books I read long ago. A VERY DOPAMINERGIC COMBO IS MODAFNIL(200-300mg) + BACLOFEN(25-75mg) another is BACLOFEN(25-50mg)+MEMANTINE(10-20mg)+PRAMIPEXOLE(1-3mg) or a cocktail of RITALIN/BUPROPION(300-450mg) + EFFEXOR (150-225mg )+ BACLOFEN (50mg)IF U WANNA BLUES TRY PREGABALIN (900-1200mg) +VALIUM(20mg)+BACLOFEN(25-50mg)+XANAX1mg - take a shower, watch TV, chill out -:)BTW for u'r anxiety try escitalopram (lexapro 10)for 21 days though within 3 days u'll feel it, or paxil cr 25 these 2 SSRI act very fast, as does remeron start from a low dose or Desyrel from 25mg at bedtime-if u can get any of these from friends or anyone and give them atleast 21 days trial I'm sure u won't need a benzo,(though if u had come to me I would have started on Xanax 1mg or Klonopin 0.5mg) u can sedate with a tricyclic like Elavil 25

psychihelp
14-09-2010, 20:44
SWIM is on 12 mg's of suboxone daily and was prescribed one hundred and twenty 10 mg baclofen. The first two times SWIM took around 70mg's but didn't really know what to think about it, just felt weird and out of it and very clumsy and tired the next day. SWIM waited about a week to try this again because of all the positive and recreational effects SWIM's read about, and this time felt absolutely amazing. Very euphoric and SWIM has never tried GHB but could imagine it's very similar. SWIM had alot of energy and was very motivated. Also would doze off randomly and then randomly would have bursts of euphoric energy.. Absolutely had no anxiety and SWIM would think it's like a mix of Valium and GHB. Definitely euphoric and really looking forward to doing again. SWIM has also noticed that a dose of 60 mg's works perfect everytime and no tolerance has set in. This is also my very first post on bluelight so I apogize if this carried on too much or if I broke any bluelight rules.

I don know who's SWIM, I had myself in dr bob's psychobabble- u can't unsubscribe- it's a scam, anywho SWIM seems a fictitious character with all the doses mentioned or he'll have to be in a mental home for a few a yrs if he wants to live.recreation is good, i do it, even if u do it everyday , if it's a sensible cocktail.Suboxone cancels any opiod joy from baclofen, then GHB binds to GABA-A site which first will obviously will extremely euphoric if u can remember first time u took a benzo .Valium is again mainly a GABA-A agonist , if u need 60mg soon u'll need 120 , what's the supply its raining valium?I don wan't to quarrel goto a doc, or ask online for cocktails from docs like me, I don mind if someone is on methadone.

BloodTranceFusion
05-10-2010, 07:46
Someone who isn't Me (http://www.urbandictionary.com/define.php?term=swim)

"Most people use this abbreviation when telling some story about them doing something unsavoury, to avoid reprimand." ;)

Lombergerh
05-10-2010, 19:48
I would like to warn you, please do not take doses of more than 200mg, and please do not mix with alcohol.
It's actually dangerous.
Pretty not bad mixed with marijuana or small doses of DXM (500mg)

PS In my opinion Phenibut is better for the mixing, because it has fewer side effects.

Jeanieemairieee
02-06-2011, 15:46
Baclofen is a muscle relaxer, I've had it given to me before for muscle pain, and honestly it never even helped with pain nor did it give me any other sensations.

King Hop Head
13-10-2011, 16:20
As Baclofen is similar to Penibut, it will not be that recreationally, though is relaxing and uplifts mood. I use Phenibut to Potentiate Poppy Tea. Have Baclofen on order, and will try that with Poppy Tea when it arrives.

Phenibut often causes nausea or stomach issues (particularly the 6 to 24 hours after dosage) does this apply to Baclofen?

Tripman
13-10-2011, 16:51
Hi , I'm a neuropsych meself, doesn't mean I don enjoy pot, or never tried heroin , but I now mostly enjoy pharma cocktails:D lets talk of baclofen
Try Baclofen if u wanna feel good , its a GABA-B selective agonist - that'll relax muscle spasms due to injury, but gaba-b agonism DISINHIBITS AND SLOWLY SPEEDS UP DOPAMINERGIC transmission in pleasure centres of the brain. also seroternergic neurotransmission speeds up via indirect action on 5HT1A receptors and a happy relaxed state arises the higher u dose. BUT PLEASE DON GO ABOVE 75-100 mg and that's all this doctor can remember from the fat books I read long ago. A VERY DOPAMINERGIC COMBO IS MODAFNIL(200-300mg) + BACLOFEN(25-75mg) another is BACLOFEN(25-50mg)+MEMANTINE(10-20mg)+PRAMIPEXOLE(1-3mg) or a cocktail of RITALIN/BUPROPION(300-450mg) + EFFEXOR (150-225mg )+ BACLOFEN (50mg)IF U WANNA BLUES TRY PREGABALIN (900-1200mg) +VALIUM(20mg)+BACLOFEN(25-50mg)+XANAX1mg - take a shower, watch TV, chill out -:)BTW for u'r anxiety try escitalopram (lexapro 10)for 21 days though within 3 days u'll feel it, or paxil cr 25 these 2 SSRI act very fast, as does remeron start from a low dose or Desyrel from 25mg at bedtime-if u can get any of these from friends or anyone and give them atleast 21 days trial I'm sure u won't need a benzo,(though if u had come to me I would have started on Xanax 1mg or Klonopin 0.5mg) u can sedate with a tricyclic like Elavil 25

If this guy is a neuropsych then i'm a fish.

AlphaOdure
11-06-2012, 00:19
Suboxone cancels any opiod joy from baclofen
Uhh, no; baclofen has no direct activity at mu-opioid receptors (or ANY opioid receptors for that matter).. its main action is as a GABA-B agonist.


then GHB binds to GABA-A site
Uhh, wrong. Strike two.. GHB is a GABA-B agonist.


LOL; to Tripman...

If this guy is a neuropsych then i'm a fish.
HAA! ..I was thinking exactly the same thing in regards to psychihelp. Apparently his "med schooling" didn't include grammar lessons? Doesn't even know the difference between GABA sub receptors & apparently thinks baclofen has opioidergic activity? So if he actually is a doc.. one, I pray to god (even though i'm an atheist) i never have him; and two, he should demand a tuition-refund from whatever shit school he supposedly went to.

effie
11-06-2012, 02:20
^ Agreed, there are several inaccuracies in that post. However this is an old thread, and psychihelp made their post in 2010 so I'm going to close this - we're a quick q&a forum and traffic moves fast :)

Closed, if you have any queries feel free to shoot me a PM.