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BongoBongo
25-11-2003, 11:14
Has anyone heard of Milk of Magnesium prior to rolling??

http://www.pillreports.com/viewpill.php3?sub=-1&area=1&id=38088


Anyone????????

MazDan
25-11-2003, 11:33
yeah I am tryin it this weekend...........u will find a whole thread in ecstasy discussion.

On a similar line......BT would u know if Mylanta would be basically the same???..meaning likely to achieve the same results???

My chemist didnt have any MOM but suggested I tried Mylanta.

phase_dancer
25-11-2003, 11:35
No I haven't heard of it being used, but it will certainly affect the pH in your stomach. If you took it early enough before MDMA so that it was completely neutralised, but not long enough for any acid rebound to occur, it should dramatically affect absorption which could result in a super fast come on.

As neutralisation of Mg(OH)2 occurs rapidly and completely in the stomach, it is unlikely plasma and urinary pH would be dramatically affected, unlike the bicarbonate ion which has a more pronounced affect both in the stomach and compartmentally. This is because the ion can diffuse the stomach wall and it takes longer to restore the pH imbalance. Therefore Milk of Magnesia would not be expected to prolong the duration of the effect as does a urinary alkalizer

PLEASE NOTE: Any substance which may cause increased or rapid absorption of a drug should be used with care. Plasma levels will rise very quickly, and physiological responses such as temperature increases can be significant. Be careful%)

phase_dancer
25-11-2003, 11:54
Mylanta will have a similar affect and be slightly longer lasting.

MazDan
25-11-2003, 12:15
Originally posted by phase_dancer
Mylanta will have a similar affect and be slightly longer lasting.

Thanks PD..........what sort of dose would you recomend and how long before dropping????

phase_dancer
25-11-2003, 12:34
At a guess I'd say around 20mins before. Many people say that an extra alkali environment increases absorption, but I'm a little skeptical as too alkali an environment would liberate the freebase which is not water soluble.

As mentioned on the E discussion thread, alkalizing is an old trick and one which has been addressed many times on this forum. Be aware that it definitely increases toxicity as plasma levels peak at a higher level even if the duration is not increased.

Mylanta and Mylanta-II are rated differently. Std Mylanta has 200mg each of Al(OH)3 and Mg(OH)2 per 5ml dose. This should be enough.

Also Remember Al(OH)3 forms insoluble compounds which are constipating. Aluminium in this form also reacts with many drugs, not least amines and proteins.

It may be a lot better to stick with magnesium hydroxide if you're intent on trying to up the absorption rate.

BigTrancer
25-11-2003, 14:23
Good info PD :D One further thing I'd mention is that if you're taking something containing magnesium, it can be beneficial to help to reduce jaw cramping and lessen the intensity of teeth grinding that MDMA can cause. Even if it doesn't greatly improve your drug absorption or the roll, easing up the jaw can really make a difference.

BigTrancer :)

alexkid
25-11-2003, 15:52
how about grapefruit juice?

i could b way off but im sure i saw something on telly a while ago about about how it can increase the effects of drugs 10 fold but also shorten the duration?

anyone got the facts?

Splatt
25-11-2003, 16:13
^ crap.

Fry-d-
25-11-2003, 16:25
Not complete crap though.....

Grapefruit (http://www.globalrph.com/gfruit.htm)

An urban legend maybe, but not not true ;)

From mine and others experiences it doesn't have much of an effect though. Depends what drug your combining it with though.

wazza
26-11-2003, 01:00
Seems you can get increased sedation with benzos with grapefruit juice according to http://emphysemafoundation.org/Grapejuice.html

BigTrancer
26-11-2003, 01:15
Grapefruit works (slightly) because it inhibits the action of P450 3A4 enzyme in the liver, which is secondarily responsible for metabolising MDMA. However, 3A4 is not nearly as important in the metabolism of MDMA as is the enzyme 2D6... so the grapefruit doesn't do all that much to increase the duration or intensity of MDMA. IMO it does work a little though.

BigTrancer :)

Splatt
26-11-2003, 09:08
x 10 tho... mega exaggeraton :)

3munch3r
26-11-2003, 09:41
how would drugs such as Zantac (ranitidine hydrochloride) in combination with MoM help? which I believe stops you from producing stomach acids.

Not getting past grade 8 chem, i have no idea on the implications.

Can anyone comment?







Be Safe

BigTrancer
27-11-2003, 01:47
I've used proton pump inhibitors like Nexium before (which are used to combat indigestion) before and after MDMA without ill effects in the past, but I don't take them often.

BigTrancer :)

Killing_time
29-11-2003, 17:34
Hmmm.
So if I take a multitude of Mylanta does that mean I could risk/benefit from a superfast come on?
I'm slightly confused?
What about at normal doses?

phase_dancer
30-11-2003, 01:19
A normal dose will be sufficient to alter pH in the stomach to ~8-9 for a period. Almost ideal for quick assimilation, providing the Al3+ doesn't react with the amine in the presence of enzymes. For that reason it may be better to stick with the MoM. With the public views/fears towards aluminium I'd be very surprised if Milk of Magnesia wasn't still available. Check around, or ask your Grandmother.

Insane Platypus
30-11-2003, 03:38
Isn't Milk of Magnesia banned in Australia? Well according to this food additives site I am looking at, it is.

http://www.mbm.net.au/health/500-585.htm

superbabydoc
01-12-2003, 07:33
Re: Zantac and MDMA, there was a post in Health Q & A (now purged alas) about a person who took Zantac regularly, and one night took 2 pills. She then experienced what sounded like a minor MDMA overdose. Her friend who had taken 2 pills was fine. If I remember rightly, she was hallucinating, vomiting, dizzy and had trouble walking etc.

I found one article that stated Zantac was an inhibitor of CYP2D6. As BT stated, this is the enzyme that does most of the metabolising of MDMA, and if you inhibit its action, MDMA will be metabolised more slowly leading to increased blood levels. Other sources stated however that Zantac did not inhibit CYP2D6, including the manufacturer. Which left me a bit perplexed. Perhaps the acid neutralising effect of the Zantac was solely responsible for the overdose? Anyhow, her experience suggests you should proceed carefully if you plan on trying this combination. For example, don't start by taking multiple pills.

phase_dancer
22-12-2003, 08:48
With the public views/fears towards aluminium I'd be very surprised if Milk of Magnesia wasn't still available. Check around, or ask your Grandmother.

This is typical of a non-researched response. If the poster had looked or even thought a bit, it would be quite obvious why milk of magnesia is no longer available as an ant-acid......8)


It was of course me who was that silly poster :\. Magnesium is not only absorbed through the gut at a much higher rate than aluminium, but has also been found to form protein complexes with aluminium, making the 2 potentially harmful in some preparations.

The big concern with prolonged magnesium intake is of course renal toxicity; magnesium being toxic to the kidneys (and bladder too I think?). With these sorts of stupid mistakes and suppositions, it's easy to understand any reluctance I have about posting in any "authoritative" fashion in Q & A. Basic physiology, you'd never believe it was a distinction subject [forehead slap imminent --> p_d]....:o

MoeBro
25-12-2003, 05:55
BT can you elaborate on the positive or otherwise ill effects of P-P inhibitors during rolling?

rm1x
25-12-2003, 06:02
Originally posted by 3munch3r
how would drugs such as Zantac (ranitidine hydrochloride) in combination with MoM help? which I believe stops you from producing stomach acids.

Not getting past grade 8 chem, i have no idea on the implications.

Can anyone comment?







Be Safe


I'd be careful with Zantac period. I had a friend that was on it for years and she would break down into tears over the littlest things. She was actually quite nutty towards the end of her use of it, she ended up getting put on another stomach pill and within days she was better, one of the side effects was depression :|

Co_oKie_AnaLYsT
26-12-2003, 07:39
The big concern with prolonged magnesium intake is of course renal toxicity; magnesium being toxic to the kidneys (and bladder too I think?).

i use calcium and magnesium tablets each night before i go to bed because i grind my teeth something cronic. My teeth grinding can wake me up in the middle of the night it is that noisy. will this use have any effect on my kidneys etc

phase_dancer
26-12-2003, 07:43
I wouldn't like to say. It would be dependant on the form the minerals are in. Check with your doctor, and don't worry, short term exposure to magnesium isn't likely to do anything more than give you the runs.

Co_oKie_AnaLYsT
26-12-2003, 07:45
ive been using it for 6 months

phase_dancer
26-12-2003, 21:37
See your doc. The dosages in these preparations shouldn't present any problems. These are not the same levels seen in antacid preparations, and are possibly even in a different form [?]. Mg and Ca are essential minerals, so small/ moderate doses should do no harm unless you were pre-disposed in some way.

I'm sure your daily intake of magnesium would be way less than someone dosing several times a day with milk of magnesia.

bzzzzzzzzzzzzzzzzzzz
30-01-2004, 05:33
These are a few things I’ve picked up off this site, others, and advice from friends. I've been taking MDxx for a year and a bit and I am interested in finding out peoples’ suggestions. I know some of these things have been posted before in other topics but i'm keen to get together a good discussion about it.

The following are things that I have tried, which have been recommended. If anyone has any comments (for or against these things) or any other tips that work well, I’d love to hear them! Also I am interested in any corrections, as this is all what I have been lead to believe. I’m not saying any of it is fact, so I’m more than happy to know if I’m wrong!

L-Tryptophan 95mg:
This is an amino acid, often used to temporarily relieve insomnia.
I've been told this is similar to 5-HTP and helps to restore serotonin levels.
I found that after a big weekend, during the week taking 1 or 2 tablets per day for a week or so seemed to have a good effect next time I dropped. I have been told you should probably not take L-Tryptophan within 24 hours of dropping, as it has the possibility of having an opposite effect to extacy, as one is replacing serotonin and one is releasing it. I noticed this seemed to lower my tolerance levels also, and is a great way to sooth comedowns.

Magnesium
Good way to reduce jaw-clenches. I haven’t tried this personally but have friends who have and say it works well. Will be giving it a go tonight.

Gatorade
I’ve been told its good to have before or during.

Mylanta
I wasn’t sure what the final verdict (if there was one) was on this. As I am aware, it lowers the acidity level in the stomach and assist with faster absorption and a quicker come-on (?)

Berocca
I don’t know what the effect of taking Berocca before dropping is (if any) but I know it always makes me feel a little better after a massive night. Also I’ve been told that its good to have Berocca after doing Nitrous Oxide because it restores Vitamin B levels, which can become depleted from it (Nitrous Oxide).

Water
Goes without saying.

Food and Multi-Vitamins
Also, making sure you’re eating nutritional meals, plenty of carbohydrates (bananas are great) and taking multi vitamins is essential for making sure your body has enough energy to last a long night (or two). I tend to eat a really good meal in the early part of the day before dropping, but make sure I don’t have too much in my stomach by the time I actually drop.

As I said above, please comment freely on this.

DayTrippa
03-02-2004, 11:36
Ive been taking quickeze before dropping for about 12 months, and can confirm that it works, even with ordinary pills! Makes them much more potent.
Used quickeze before a cap once and BOOOOOOOOOOM!!! Im reasonably experienced and it rocked me hard! it works crazy good people, so party safe and cautious.