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Would this drug cross the BBB?

I don't think it would be very fun. It is a moderately selective 5-HT3 agonist, meaning it would likely produce nausea and vomiting.

In general, 2-methyltrypamine derivatives don't seem to produce effects that would encourage recreational use.
 
Serotonin does not cross the BBB because it is immediately metabolised by monoamine oxidase enzymes. The same thing applies here. 2-methylserotonin would probably be immediately metabolised and would not be able to cross the BBB.

Drugs like 5-HTP can only enter the brain because the brain has amino acid transporters which actively carry it into the brain. If you had 2-methyl-5-hydroxytryptophan, that would enter the brain in much greater concentrations and be metabolised into 2-methylserotonin eventually.
 
aced126 said:
Serotonin does not cross the BBB because it is immediately metabolised by monoamine oxidase enzymes. The same thing applies here. 2-methylserotonin would probably be immediately metabolised and would not be able to cross the BBB.
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That may or may not be true. Shulgin found that 2-methyl-DMT is orally active and theorized that 2-alkyl groups may impair metabolism of tryptamines by MAO.

2-Alkylation tends to abolish 5-HT2A binding, but some tryptamines with 2-alkyl groups do show central activity after peripheral administration.

2-Methyltryptamine has a free amine, so it may be less metabolically stable then 2-methyl-DMT. But again, it might not.
 
serotonin2A,

Are you then suggesting we get together and take turns vaporizing large quantities of nearly pure

2-methyl-3-dimethylaminoethylindole.png


2-METHYL-DMT just for the Hell of it to see what happens? If so, then I whole heartedly agree. Your place or mine?
 
https://www.erowid.org/library/books_online/tihkal/tihkal34.shtml

this happens:

not a psychedelic ; called a tactile stim

(with 50 mg, orally) "There was tingling everywhere but it faded after about three hours. Nothing else."

(with 75 mg, orally) "Very mild stomach rumbling during the first hour, with no other effects until the 65 minute point. Then there was the onset of as very mild relaxed feeling followed by intermittent skin alerting, especially on the head and neck. No visuals. Sexual activity at 90 minutes showed marked enhancement of both the pre-climactic and orgasmic phase, which was confirmed by repeat activity at 120 and 180 minutes. When I switched on TV to a familiar news announcer, I thought that he had a cold because his voice sounded lower than normal, and throaty. Later I picked up a phone to call a friend and both the dial tone and the touch-tones sounded very unusual. Music at this point sounded normal, but I am sure that some tonal perception was altered by this drug. The effects seemed almost gone by 4 hours and were undetectable by 5 hours. Appetite seemed unaffected throughout, and dinner at the 5-hour point was very good. No GI problems occurred, and there were no after effects the next day."

(with 90 mg, orally) "The entire body was becoming activated (in a good way) but not much going on in the head. I am mentally clear but with the entire touch system a bit more activated than I would choose. This peaked at 3 hours, and was gone in another 3 hours. Everything is tactile."

(with 120 mg, orally) "There is as much to be said for what didn't happen as for what did. No visual changes. No cloudiness of the thought processes. No motor impairment what-so-ever. There was some down-shifting of music, with some distortion, which was overall more annoying than interesting. But I am glad I am alone because I cannot wear clothing. Anything touching the skin makes all my hair stand on end. The erection of my nipples is almost painful. Exploring sexual stimulation is seemed a little dangerous but explored anyway. The climax was disappointing. Too much activity of a slightly scary sort. Never again at this level.
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