Probably not much no, just make sure you sleep enough and eat properly. Don't use MDMA and coke on the same night though, they compete with eachother and so cancel eachother out. Also a remarkable big part of negative stories we encounter in this forum start with the combo MDMA+coke, it's something that really caught my eye so I always advice against it. If you want to be extra careful, don't use coke on Friday, only Thursday. But I don't think using Friday as well will be that harmful. Just not on the same night