bipolar-sunshine
Bluelighter
- Joined
- Sep 2, 2016
- Messages
- 129
Anyone?
N&PD Moderators: Skorpio | thegreenhand
Put simply, both drugs have inhibitory effects on activity in certain areas of the brain, and when co-administered they have a stronger effect than either drug alone.
http://www.ncbi.nlm.nih.gov/pubmed/6132369
Anyone?
So shouldn't benzos decrease the analgesic effects of opioidsThe midbrain region periaqueductal grey (PAG) is rich in opioid receptors and endogenous opioids and is a major target of analgesic action in the central nervous system. It has been proposed that the analgesic effect of opioids on the PAG works by suppressing the inhibitory influence of the neurotransmitter GABA on neurons that form part of a descending antinociceptive pathway. Opioids inhibit GABA-mediated (GABAergic) synaptic transmission in the PAG and other brain regions by reducing the probability of presynaptic neurotransmitter release, but the mechanisms involved remain uncertain.