Hmmmm, probably when my friends father passed away from cancer, and I obtained bottles of morphine, boxes of fentanyl patches and hydrocodone.
Unfortunately, this was my first foray into opioids (i was in high school) and with my first dose of morphine i fell in love. The drugs sat in my medicine cabinet untouched for months, then one day after having a fight with my mother and later in the evening, my girlfriend, i decided to sample the oral morphine solution. I dosed 20mg, sat down and watched TV, feeling warm and at peace. I then went to bed and slept like i hadn't since i was a child, and woke up to a bright shimmering shining California day. That was my biggest score and the beginning of the end.
Note: gonna transfer this to drug culture since its not really about drugs (at least, not with specificity)