What happens to dopamine (in prefrontal cortex) if you take..

[SirSwede]

What happens to dopamine (in prefrontal cortex) if you take a 5ht2c antagonist and 5ht2c inverse agonist?

Thanks!

 

[Cotcha Yankinov]

Generally 5-HT2C activation leads to a decrease in PFC dopamine, and 5-HT2C antagonist/inverse agonists (which do have different effects on the midbrain) tend to increase dopamine cell firing

5-HT2C antagonists injected directly into the PFC on the other hand seem to have little to no effect on dopamine in PFC

 

[CFC]

You may find this an interesting read OP

 

[SirSwede]

You may find this an interesting read OP

Yeah I know, thanks!

What I trying to get at is being able to take the Agomelatine without as much increase in dopamine in the prefrontal cortex.

 

[SirSwede]

Generally 5-HT2C activation leads to a decrease in PFC dopamine, and 5-HT2C antagonist/inverse agonists (which do have different effects on the midbrain) tend to increase dopamine cell firing

5-HT2C antagonists injected directly into the PFC on the other hand seem to have little to no effect on dopamine in PFC

So does that mean that Risperidone can, possibly, increase mid-brain dopamine cell firing?