trainman04
Bluelighter
- Joined
- Dec 18, 2017
- Messages
- 189
Hello, Im wondering are there any diseases that can make you have too much CRH (cortisol releasing hormone)? I think my anxiety is caused my too much CRH but someone said that is unlikely becuase there is a feedback loop if there is too much CRH then cortisol will be increased which will shut down CRH release. But I started looking up and I found a rare case of Cushings syndrome, rare case of CRH-secreting tumors (without ACTH secretion) have been reported, which stimulates pituitary ACTH production. There is like 15 reports of CRH tumor very rare.
So this would be the only plausible explanation for which there is too much CRH that there is not enough cortisol that would be able to inhibit it. A tumor that secrets CRH.
If we look at this picture: https://bengreenfieldfitness.com/wp-content/uploads/2013/08/Basic_HPA_Axis.jpeg
If there is a CRH tumor that would mean it releases CRH 24/7, which would be impossible for the cortisol to inhibit becuase CRH would make you in a constant fight/flight mode and your anxiety would just get worse and worse and eventually the ACTH would go down becuase the anxiety would be so much the pituitary would give up. The cortisol would just stay high. But the CRH would still keep being released. Any experts here that can explain to me more about this CRH-secreting tumor? Im just trying to learn more about this CRH stuff.
I read this SelfHacked article and everything fits how I feel: https://www.selfhacked.com/blog/why-your-health-problems-worsen-after-stress-the-role-of-crh/
the article also mentions there is In Hashimotos and UC(Ulcerative colitis?), inflamed tissues contained large amounts of CRH.
Im gonna have an full body MRI soon. I had a Brain scan Only and it was fine but im thinking the tumor is somewhere else.
What else can cause so much CRH that your body can not handle? just a tumor?
Also Is it more plausible to have a CRH or CRF1 secreting tumor? Is the second even possible? CRH is a peptide hormone and CRF1 is a protein.. have not seen any study with CRF1 secreting tumor just CRH.
Here is another thread I made on another site with more information about this stuff:
https://www.longecity.org/forum/topic/100998-what-can-cause-excessive-crh-or-acth/
So this would be the only plausible explanation for which there is too much CRH that there is not enough cortisol that would be able to inhibit it. A tumor that secrets CRH.
If we look at this picture: https://bengreenfieldfitness.com/wp-content/uploads/2013/08/Basic_HPA_Axis.jpeg
If there is a CRH tumor that would mean it releases CRH 24/7, which would be impossible for the cortisol to inhibit becuase CRH would make you in a constant fight/flight mode and your anxiety would just get worse and worse and eventually the ACTH would go down becuase the anxiety would be so much the pituitary would give up. The cortisol would just stay high. But the CRH would still keep being released. Any experts here that can explain to me more about this CRH-secreting tumor? Im just trying to learn more about this CRH stuff.
I read this SelfHacked article and everything fits how I feel: https://www.selfhacked.com/blog/why-your-health-problems-worsen-after-stress-the-role-of-crh/
the article also mentions there is In Hashimotos and UC(Ulcerative colitis?), inflamed tissues contained large amounts of CRH.
Im gonna have an full body MRI soon. I had a Brain scan Only and it was fine but im thinking the tumor is somewhere else.
What else can cause so much CRH that your body can not handle? just a tumor?
Also Is it more plausible to have a CRH or CRF1 secreting tumor? Is the second even possible? CRH is a peptide hormone and CRF1 is a protein.. have not seen any study with CRF1 secreting tumor just CRH.
Here is another thread I made on another site with more information about this stuff:
https://www.longecity.org/forum/topic/100998-what-can-cause-excessive-crh-or-acth/
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