What makes you think you're having vasoconstriction?
What is your heart rate like?
All of these can be very dangerous when mixed with amphetamines because vasodilation will cause reflexive tachycardia (increased heart rate)... stack that on top of increased HR from amphetamine and you could be finding yourself having a heart attack...
But in theory, you could use:
Clonidine (arterial system) - an a2 agonist that acts in the CNS, tricking the brain into thinking circulating catecholamine levels are higher than they actually are, and causing a reflexive peripheral vasodilation via decreased release of norepinephrine
Phentolamine (arterial system)- We use this in the ER for amphetamine overdoses. It's a peripheral a1 and a2 antagonist, but it is a competitive inhibitor so taking more amphetamine will just cancel out its effects
Nitroprusside (venous system) - Direct vasodilator
Nitroglycerin (venous system) - Direct vasodilator with specificity for coronary arteries
Ahh he meant penis but anyway, hey ER man, I've been experimenting with this for some time (med stud).
I have some questions first:
1. Does clonidine not work peripherally at all? Also, in bigger doses, it starts to agonise alpha2B which theoretically neutralizes its effect, does this mean it would be okay to take more clonidine if the pressure dropped too low? (Guess not <haha...;>)
2. Would nitroglycerin gel on skin near the heart be better than oral? (My guess is yes)
3. I see no beta-blockers, why? I've read about the contraindications a lot but never with a sound explanation, except making more NE available for alpha-Rs which has been debunked...
4. GHB?
So far I've tried: nebivolol (peripheral NO synthesis, in addition to slower HR = less need for oxygen); clonidine - very pleasant, the best effect so far; ginkgo - helps more mentally; hawthorn - halfway helpful. Eating a nutritious meal is among the best though.
And there is one more substance that made a clear difference - CDP-choline: I must have been really worn out because of having been disturbing both my sleep and digestion... I've been taking a lot, and clearly even after sleep my body wouldn't regenerate fully. But today I've taken citicoline, because I thought that perhaps my sympathetic nervous system is unable to shut up... And wow, I took 2 gs for maximum effect, which made me feel myself again... It's like returning to someone you knew before "all this". What's even more significant, is that after something wears off, I can actually feel my tiredness come in healthy ways... I feeel sooooo relieved, and I'm much more stable and collected during main effects too. I wonder whether I have been cachectic to the point of choline deficiency, or it's just a supporting nutrient for the overall state of chronic sympathetic activation.
I will be trying ashwagandha in a moment too. Since it regulates the sympathetic response, maybe it could further minimize the drug's peripheral adrenergic effect... People report this on reddit etc.
I hope you're still here! haha
Cheers
