Hey all. I haven't smoked weed in about 6 months, as I'm trying to clear the brain fog before fall semester starts, as I feel it dumbed me down last spring semester. Anywho, I'm wondering what you think weed's affects on serotonin are?
I had an incident where I took a small dose of kratom, smoked a huge dab, and ended up having very mild serotonin syndrome like symptoms that lasted for about 6 hours.
After using many serotonergic drugs, and being prescribed SSRI's, SNRI's and tramadol on and off for the last 10 years, I can definitely tell that weed does SOMETHING to serotonin. Which is why I believe so many with depression and anxiety turn to weed, even though weed tends to worsen anxiety and depression. I haven't been able to find any scientific studies on weed's affects on serotonin, but I definitely know it affects it in some way, just from how it feels.
I personally think it modulates serotonin in a way that LSD does, but does not agonize or release it, just changes the way it's used. If it released or agonized serotonin you would constantly hear of terrible SS stories, and OD's from weed, but like LSD, I believe it just modulates it in an odd way that can cause seizures and bad reactions when mixed with MAOI's or serotonergic drugs.
I do not feel it affects dopamine significantly, however I do know it releases mass amounts of norepiniphrine as welll, but I have also read a study that weed mildly affects your kappa opioid receptors. This is why new users can become very dissassociated and nauseous on strong bud, the same way that a high dose of the opioid tapentadal, or kratom can get you feeling.
What are your opinions on weed, serotonin, and your kappa opioid receptors.?
I had an incident where I took a small dose of kratom, smoked a huge dab, and ended up having very mild serotonin syndrome like symptoms that lasted for about 6 hours.
After using many serotonergic drugs, and being prescribed SSRI's, SNRI's and tramadol on and off for the last 10 years, I can definitely tell that weed does SOMETHING to serotonin. Which is why I believe so many with depression and anxiety turn to weed, even though weed tends to worsen anxiety and depression. I haven't been able to find any scientific studies on weed's affects on serotonin, but I definitely know it affects it in some way, just from how it feels.
I personally think it modulates serotonin in a way that LSD does, but does not agonize or release it, just changes the way it's used. If it released or agonized serotonin you would constantly hear of terrible SS stories, and OD's from weed, but like LSD, I believe it just modulates it in an odd way that can cause seizures and bad reactions when mixed with MAOI's or serotonergic drugs.
I do not feel it affects dopamine significantly, however I do know it releases mass amounts of norepiniphrine as welll, but I have also read a study that weed mildly affects your kappa opioid receptors. This is why new users can become very dissassociated and nauseous on strong bud, the same way that a high dose of the opioid tapentadal, or kratom can get you feeling.
What are your opinions on weed, serotonin, and your kappa opioid receptors.?
Last edited: