I am wondering what anyone thinks about this. The use of Seroquel (quetiapine) at night to reduce amphetamine tolerance. I am not sure what the dosage would be, but 25 mg is enough to knock me out, even if I'm wired from my Adderall or Dex.
The theory is that Seroquel's half-life is so short (only 6 hours) so that by the time you take your next stimulant dose, it will not interfere or block the stimulant.
But at night, it will participate in upregulation of dopamine receptors because of its dopamine-blocking properties.
Then, for at least 6 hours/24hrs, your dopamine receptors are going to be free of amphetamine, thus contributing to a lessening of tolerance.
Because the reason tolerance develops is that the dopamine receptors are constantly saturated with amphetamine and then become desensitized to amphetamine, so you need more to get the same effect. Seems like Seroquel would serve to resensitize the dopamine receptors so that you wouldn't need as much amphetamine to get the same good response from it.
What does anyone think? An antipsychotic such as aripiprazole, with about a 3 day half-life, woud not work this way. It would probably lower tolerance, but with the side effect of having the amphetamine blocked for 3 days, so that someone might take more and more of the amphetamine to try to overcome that.
I see the short half-life of Seroquel as being key here.
Any thoughts?
The theory is that Seroquel's half-life is so short (only 6 hours) so that by the time you take your next stimulant dose, it will not interfere or block the stimulant.
But at night, it will participate in upregulation of dopamine receptors because of its dopamine-blocking properties.
Then, for at least 6 hours/24hrs, your dopamine receptors are going to be free of amphetamine, thus contributing to a lessening of tolerance.
Because the reason tolerance develops is that the dopamine receptors are constantly saturated with amphetamine and then become desensitized to amphetamine, so you need more to get the same effect. Seems like Seroquel would serve to resensitize the dopamine receptors so that you wouldn't need as much amphetamine to get the same good response from it.
What does anyone think? An antipsychotic such as aripiprazole, with about a 3 day half-life, woud not work this way. It would probably lower tolerance, but with the side effect of having the amphetamine blocked for 3 days, so that someone might take more and more of the amphetamine to try to overcome that.
I see the short half-life of Seroquel as being key here.
Any thoughts?