Is it possible to take mdma on vraylar? Most antipsychotics are antagonists for 5ht1a, vraylar is an agonist. I know one of these replies is going to be telling me not to mix mdma with this medication due to the underlying condition being treated, but i've taken MDMA before and i've been fine. I'm really just curious if i would be able to safely take MDMA on this medication. Hoping someone here can help me out with an answer, i'm not as up on the chemistry to know whether MDMA would have an effect on this particular drug. Much appreciated